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    Cyclic azapeptides with angiogenic effect
    7.
    发明授权
    Cyclic azapeptides with angiogenic effect 失效
    具有血管生成作用的环状氮杂肽

    公开(公告)号：US06534478B1

    公开(公告)日：2003-03-18

    申请号：US09446974

    申请日：2000-03-23

    申请人： Alfred Jonczyk ,  Simon Goodman ,  Horst Kessler ,  Jochen Wermuth ,  Jörg Schmitt

    发明人： Alfred Jonczyk ,  Simon Goodman ,  Horst Kessler ,  Jochen Wermuth ,  Jörg Schmitt

    IPC分类号： A61K3800

    CPC分类号： C07K7/56 ,  A61K38/00

    摘要： Compounds of the formula I cyclo-(aArg-aGly-aAsp-aX-aY)  I in which aArg, aGly, aAsp, aX and aY have the meanings indicated in claim 1, and their salts, can be used as integrin inhibitors, in particular for the prophylaxis and treatment of diseases of the circulation, in thrombosis, cardiac infarct, coronary heart diseases, arteriosclerosis, in pathological processes which are supported or propagated by angiogenesis and in tumour therapy.

    摘要翻译： aArg，aGly，aAsp，aX和aY具有权利要求1所述含义的式Ⅰin化合物及其盐可用作整联蛋白抑制剂，特别是用于预防和治疗血栓形成疾病， 心肌梗死，冠心病，动脉硬化，血管生成和肿瘤治疗支持或传播的病理过程。

    RADIATION-CURING BINDERS AND A PROCESS FOR THEIR PREPARATION
    8.
    发明申请
    RADIATION-CURING BINDERS AND A PROCESS FOR THEIR PREPARATION 有权
    辐射固化粘合剂及其制备方法

    公开(公告)号：US20100105792A1

    公开(公告)日：2010-04-29

    申请号：US12651576

    申请日：2010-01-04

    申请人： Jan Weikard ,  Christoph Gürtler ,  Wolfgang Fischer ,  Jörg Schmitt ,  Holger Mundstock

    发明人： Jan Weikard ,  Christoph Gürtler ,  Wolfgang Fischer ,  Jörg Schmitt ,  Holger Mundstock

    IPC分类号： C08G59/68

    CPC分类号： C08G18/8175 ,  B33Y70/00 ,  C09D175/14 ,  Y10T428/31551

    摘要： The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups) and 3) optionally NCO-reactive groups, by reacting at temperatures ≦130° C. A) one or more NCO-functional compounds containing uretdione groups with B) one or more compounds that contain isocyanate-reactive groups and groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and then C) with one or more saturated, hydroxyl-containing compounds other than B), at least one of these compounds having an OH functionality of ≧2, in the presence of D) a catalyst containing one or more ammonium salts or phosphonium salts of aliphatic or cycloaliphatic carboxylic acids, the reaction with compounds C) taking place at least proportionally with the formation of allophanate groups. The present invention also relates to the binders obtained by the process of the invention.

    摘要翻译： 本发明涉及一种制备粘合剂的方法，其包含1）脲基甲酸酯基团，2）与烯键式不饱和化合物反应的基团与暴露于光化辐射（辐射固化基团）和3）任选的NCO-反应性基团反应的基团， A）一种或多种含有脲二酮基团的NCO-官能化合物，B）一种或多种含有异氰酸酯反应性基团的化合物和与烯键式不饱和化合物反应而与光化辐射（辐射 - 固化基团），然后C）与除了B）之外的一种或多种饱和的含羟基化合物，在D的存在下，在具有OH官能度≥2的这些化合物中的至少一种的化合物中含有一种或多种铵 脂肪族或脂环族羧酸的盐或鏻盐，与化合物C）的反应至少与脲基甲酸酯基团的形成成比例地发生。 本发明还涉及通过本发明的方法获得的粘合剂。

    Catalyst
    9.
    发明授权
    Catalyst 失效
    催化剂

    公开(公告)号：US07271116B2

    公开(公告)日：2007-09-18

    申请号：US10842994

    申请日：2004-05-11

    申请人： Markus Weisbeck ,  Marie-Therese Heinen ,  Jörg Schmitt ,  Gerhard Wegener ,  Markus Dugal

    发明人： Markus Weisbeck ,  Marie-Therese Heinen ,  Jörg Schmitt ,  Gerhard Wegener ,  Markus Dugal

    IPC分类号： B01J29/06 ,  B01J29/89

    CPC分类号： B01J29/89 ,  C07D301/12

    摘要： The present invention provides a catalyst containing titanium in bonded form, non-crystalline silicon dioxide and at least one crystalline silicate phase which has a zeolite structure, wherein the non-crystalline silicon dioxide is applied to at least one of the crystalline silicate phases which have a zeolite structure and wherein at least one of the crystalline silicate phases which have a zeolite structure contains silicon-carbon bonds with which non-hydrolytically separable organic groups R are bonded to silicon. Furthermore, the present invention provides a process for preparing this catalyst and a process for producing an epoxide from a compound which contains a carbon-carbon double bond (preferably from propene) comprising reacting the compound which contains a carbon-carbon double bond with hydrogen peroxide in the presence of the catalyst according to the invention.

    摘要翻译： 本发明提供一种催化剂，其含有键合形式的钛，非结晶二氧化硅和至少一种具有沸石结构的结晶硅酸盐相，其中将非结晶二氧化硅施加到至少一个结晶硅酸盐相，其具有 沸石结构，并且其中具有沸石结构的结晶硅酸盐相中的至少一个含有硅 - 碳键，非水解可分离的有机基团R与硅键合。 此外，本发明提供了一种制备该催化剂的方法和由含有碳 - 碳双键（优选丙烯）的化合物制备环氧化物的方法，包括使含有碳 - 碳双键的化合物与过氧化氢 在根据本发明的催化剂的存在下。