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    Device for accurately marking tissue
    4.
    发明授权
    Device for accurately marking tissue 有权

    公开(公告)号：US06722371B1

    公开(公告)日：2004-04-20

    申请号：US09699254

    申请日：2000-10-27

    申请人： Thomas J. Fogarty ,  David B. Willis ,  Thomas A. Howell ,  George D. Hermann ,  Peter M. Wilson ,  M. Elizabeth Bush

    发明人： Thomas J. Fogarty ,  David B. Willis ,  Thomas A. Howell ,  George D. Hermann ,  Peter M. Wilson ,  M. Elizabeth Bush

    IPC分类号： A61B1900

    CPC分类号： A61B90/39 ,  A61B17/34 ,  A61B18/14 ,  A61B2017/00867 ,  A61B2090/3908

    摘要： This invention is an improved tissue localizing device for fixedly yet removably marking a volume of tissue containing a suspect region for excision. This invention also encompasses methods for deployment of the localizing device and its excision along with the marked tissue volume. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. The locator element path preferably encompasses the distalmost portion of the tissue volume without penetrating that volume. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Other localization wire embodiments of the invention are disclosed in which the tissue volume may be penetrated by a portion of the device. Polar and tangential deployment configurations as well as a locator element that may be cold-formed by a die in the distal portion of the deployment tube into a permanent arcuate shape are also disclosed.

    Device and method for safe location and marking of a biopsy cavity
    9.
    发明授权
    Device and method for safe location and marking of a biopsy cavity 有权
    安全定位和标记活检腔的装置和方法

    公开(公告)号：US09492570B2

    公开(公告)日：2016-11-15

    申请号：US12777710

    申请日：2010-05-11

    申请人： D. Laksen Sirimanne ,  Natalie V. Fawzi ,  Douglas S. Sutton ,  Gail S. Lebovic ,  Stanley R. Conston ,  Peter M. Wilson ,  Anne B. Morrissey ,  Mary Elizabeth Bush

    发明人： D. Laksen Sirimanne ,  Natalie V. Fawzi ,  Douglas S. Sutton ,  Gail S. Lebovic ,  Stanley R. Conston ,  Peter M. Wilson ,  Anne B. Morrissey ,  Mary Elizabeth Bush

    IPC分类号： A61B6/00 ,  A61K49/00 ,  A61B17/00

    CPC分类号： A61K49/006 ,  A61B90/39 ,  A61B2017/00539 ,  A61B2090/3925 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995

    摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

    摘要翻译： 公开了腔和前哨淋巴结标记装置，标记递送装置和方法。 更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。 公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。 组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。 该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。 还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置， 对患者的至少创伤和毒性。 组合物和方法可用于标记活检腔，以及标记前哨淋巴结。 标记方法还可以将所描述的特征与标记装置和递送装置组合。