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公开(公告)号：US08377913B2
公开(公告)日：2013-02-19
申请号：US12205998
申请日：2008-09-08
申请人： Thomas W. Von Geldern , Jufang H. Barkalow , David M. Barnes , Anthony R. Haight , John E. Hengeveld , Xiaofeng Li , Maureen A. McLaughlin , William T. Noonan , Zhonghua Pei , Jinshyun Ruth Wu-Wong
发明人： Thomas W. Von Geldern , Jufang H. Barkalow , David M. Barnes , Anthony R. Haight , John E. Hengeveld , Xiaofeng Li , Maureen A. McLaughlin , William T. Noonan , Zhonghua Pei , Jinshyun Ruth Wu-Wong
IPC分类号： A61K31/59 , C07C401/00 , A61P9/00 , A61P35/00
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24
摘要： The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
摘要翻译： 本发明涉及作为维生素D受体激活剂的化合物，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备此类化合物的方法以及在此过程中获得的中间体。
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公开(公告)号：US20090131379A1
公开(公告)日：2009-05-21
申请号：US12205998
申请日：2008-09-08
申请人： Thomas W. Von Geldern , Jufang H. Barkalow , David M. Barnes , Anthony R. Haight , John E. Hengeveld , Xiaofeng Li , Maureen A. McLaughlin , William T. Noonan , Zhonghua Pei , Jinshyun Ruth Wu-Wong
发明人： Thomas W. Von Geldern , Jufang H. Barkalow , David M. Barnes , Anthony R. Haight , John E. Hengeveld , Xiaofeng Li , Maureen A. McLaughlin , William T. Noonan , Zhonghua Pei , Jinshyun Ruth Wu-Wong
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24
摘要： The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
摘要翻译： 本发明涉及作为维生素D受体激活剂的化合物，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备此类化合物的方法以及在此过程中获得的中间体。
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3.发明申请PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 失效作为DIPPTIDYL PEPTIDASE-IV（DPP-IV）抑制剂的药物组合物公开(公告)号：US20130059873A1
公开(公告)日：2013-03-07
申请号：US13437999
申请日：2012-04-03
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/40 , C07D401/08 , A61K31/4725 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/454 , A61K31/4439 , C07D403/08 , A61K31/4025 , C07D405/06 , A61K31/506 , A61P3/10 , A61P3/04 , C07D207/16
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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4.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 有权药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US07834012B2
公开(公告)日：2010-11-16
申请号：US11510451
申请日：2006-08-25
申请人： Zhonghua Pei , Thomas von Geldern , David J. Madar , Xiaofeng Li , Fatima Basha , Hong Yong , Kenton L. Longenecker , Bradley J. Backes , Andrew S. Judd , Mathew M. Mulhern , Kent D. Stewart
发明人： Zhonghua Pei , Thomas von Geldern , David J. Madar , Xiaofeng Li , Fatima Basha , Hong Yong , Kenton L. Longenecker , Bradley J. Backes , Andrew S. Judd , Mathew M. Mulhern , Kent D. Stewart
IPC分类号： A61K31/535 , A61K31/50 , A61K31/47 , A61K31/445 , A61K31/415 , C07D295/12 , C07D487/04 , C07D217/16 , C07D211/32 , C07D231/12
CPC分类号： C07C211/48 , C07C211/40 , C07C217/52 , C07C217/54 , C07C217/74 , C07C217/84 , C07C217/86 , C07C225/22 , C07C229/42 , C07C229/48 , C07C229/60 , C07C233/43 , C07C233/78 , C07C235/46 , C07C237/24 , C07C237/30 , C07C237/42 , C07C255/54 , C07C255/58 , C07C311/22 , C07C311/36 , C07C317/22 , C07C317/36 , C07C2601/14 , C07C2601/16 , C07D207/16 , C07D209/08 , C07D209/48 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/64 , C07D213/68 , C07D213/74 , C07D213/82 , C07D217/04 , C07D263/56 , C07D263/60 , C07D277/04 , C07D277/64 , C07D295/135 , C07D295/185 , C07D295/205 , C07D317/66 , C07D319/18 , C07D333/34 , C07D333/38 , C07D409/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，代谢综合征，高胰岛素血症，肥胖症，动脉粥样硬化，各种免疫调节疾病， 和其他疾病。
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5.发明申请Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 有权药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US20070049596A1
公开(公告)日：2007-03-01
申请号：US11510451
申请日：2006-08-25
申请人： Zhonghua Pei , Thomas Geldern , David Madar , Xiaofeng Li , Fatima Basha , Hong Yong , Kenton Longenecker , Bradley Backes , Andrew Judd , Matthew Mulhern , Kent Stewart
发明人： Zhonghua Pei , Thomas Geldern , David Madar , Xiaofeng Li , Fatima Basha , Hong Yong , Kenton Longenecker , Bradley Backes , Andrew Judd , Matthew Mulhern , Kent Stewart
IPC分类号： A61K31/498 , A61K31/495 , A61K31/445 , A61K31/47 , A61K31/277
CPC分类号： C07C211/48 , C07C211/40 , C07C217/52 , C07C217/54 , C07C217/74 , C07C217/84 , C07C217/86 , C07C225/22 , C07C229/42 , C07C229/48 , C07C229/60 , C07C233/43 , C07C233/78 , C07C235/46 , C07C237/24 , C07C237/30 , C07C237/42 , C07C255/54 , C07C255/58 , C07C311/22 , C07C311/36 , C07C317/22 , C07C317/36 , C07C2601/14 , C07C2601/16 , C07D207/16 , C07D209/08 , C07D209/48 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/38 , C07D213/64 , C07D213/68 , C07D213/74 , C07D213/82 , C07D217/04 , C07D263/56 , C07D263/60 , C07D277/04 , C07D277/64 , C07D295/135 , C07D295/185 , C07D295/205 , C07D317/66 , C07D319/18 , C07D333/34 , C07D333/38 , C07D409/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，代谢综合征，高胰岛素血症，肥胖症，动脉粥样硬化，各种免疫调节疾病， 和其他疾病。
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6.发明申请Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 有权药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US20050131019A1
公开(公告)日：2005-06-16
申请号：US10935053
申请日：2004-09-07
申请人： Zhonghua Pei , Xiaofeng Li , Kenton Longenecker , Hing Sham , Paul Wiedeman
发明人： Zhonghua Pei , Xiaofeng Li , Kenton Longenecker , Hing Sham , Paul Wiedeman
IPC分类号： A61K31/4025 , A61K31/4439 , A61K31/4709 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/06
CPC分类号： C07D417/06 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, β-cell failure, obesity, satiety disorders, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的式（I）化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合症，高胰岛素血症，β- 细胞衰竭，肥胖症，饱腹感障碍，动脉粥样硬化和各种免疫调节疾病。
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7.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DDP-IV) 失效作为二肽基肽酶-IV（DDP-IV）抑制剂的药物组合物公开(公告)号：US08637546B2
公开(公告)日：2014-01-28
申请号：US13437999
申请日：2012-04-03
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/445 , C07D295/00
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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8.发明申请Pharmaceutical Compositions as Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV) 审中-公开药物组合物作为二肽基肽酶-IV抑制剂（DPP-IV）公开(公告)号：US20070238753A1
公开(公告)日：2007-10-11
申请号：US11757173
申请日：2007-06-01
申请人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
发明人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
IPC分类号： A61K31/40 , A61K31/44 , A61K31/445 , A61P3/10 , C07D207/00 , C07D207/02 , C07D401/00
CPC分类号： C07D207/16
摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物 。
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9.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US07238724B2
公开(公告)日：2007-07-03
申请号：US11036258
申请日：2005-01-13
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/40 , A61K31/401 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D405/12 , C07D401/12 , C07D211/58 , C07D239/42
CPC分类号： C07D207/16 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物 。
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10.发明申请Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US20050215784A1
公开(公告)日：2005-09-29
申请号：US11036258
申请日：2005-01-13
申请人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
发明人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
IPC分类号： A61K31/551 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/02 , C07D417/02 , C07D417/12 , C07D43/02
CPC分类号： C07D207/16 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物 。
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