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17 条记录 (耗时 0.036 秒)

    Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein
    1.
    发明授权
    Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein 失效
    测定蛋白质中磷酸酪氨酸或磷酸丝氨酸量的方法

    公开(公告)号：US5686310A

    公开(公告)日：1997-11-11

    申请号：US467717

    申请日：1995-06-06

    申请人： Timothy A.J. Haystead ,  Timothy MacDonald ,  R. Patrick Fadden

    发明人： Timothy A.J. Haystead ,  Timothy MacDonald ,  R. Patrick Fadden

    IPC分类号： C07K1/00 ,  C07K1/107 ,  C07K1/13

    CPC分类号： C07K1/003 ,  C07K1/1077 ,  Y10T436/16

    摘要： Traditional methods for measuring the phosphorylation state of cellular proteins have relied on .sup.32 P-orthophosphate labeling of cells in culture. The problems associated with radioactive isotopes have therefor prohibited phosphorylation studies on whole animals and humans. The present invention provides a unique technique that allows quantitative attachment of probes (e.g. fluorophors or biotin) to phospho-proteins and peptides by activating phospho-amino acids. the phosphorylation state of cellular proteins derived from human tissues can now be measured. This method can be used for early detection of cancer and diabetes and also for the identification of pharmaceutical agents.

    摘要翻译： 用于测量细胞蛋白磷酸化状态的传统方法依赖于32P-正磷酸盐对培养细胞的标记。 与放射性同位素相关的问题因此禁止对整个动物和人类进行磷酸化研究。 本发明提供了一种独特的技术，其允许通过激活磷酸 - 氨基酸使探针（例如荧光体或生物素）与磷酸蛋白质和肽的定量连接。 现在可以测量源于人组织的细胞蛋白的磷酸化状态。 该方法可用于癌症和糖尿病的早期检测，也可用于鉴定药剂。

    Generator with ferromagnetic teeth
    3.
    发明授权
    Generator with ferromagnetic teeth 有权
    发电机铁磁齿

    公开(公告)号：US08319390B2

    公开(公告)日：2012-11-27

    申请号：US13164023

    申请日：2011-06-20

    申请人： Gregory L. Snitchler ,  Timothy MacDonald

    发明人： Gregory L. Snitchler ,  Timothy MacDonald

    IPC分类号： H02K3/04

    CPC分类号： H02K1/165 ,  H02K7/1838 ,  H02K55/04 ,  H02K2213/03 ,  Y02E10/725 ,  Y02E40/625

    摘要： A stator assembly for use in a superconducting generator operated at frequencies up to 10 Hz is disclosed. The stator assembly includes a ferromagnetic stator winding support having a plurality of teeth defining slots, the slots configured to receive and support stator windings. The stator winding support is formed so that the ratio of the sum of the widths of the slots to the sum of the widths of the teeth and slots is in the range of 0.65 to 0.90.

    摘要翻译： 公开了用于在高达10Hz的频率下运行的超导发电机的定子组件。 定子组件包括铁磁定子绕组支撑件，其具有限定槽的多个齿，所述槽配置成接收和支撑定子绕组。 定子绕组支撑件形成为使得槽的宽度之和与齿和槽的宽度之和的比率在0.65至0.90的范围内。

    GENERATOR WITH FERROMAGNETIC TEETH
    5.
    发明申请
    GENERATOR WITH FERROMAGNETIC TEETH 有权
    发电机与非磁性材料

    公开(公告)号：US20110248509A1

    公开(公告)日：2011-10-13

    申请号：US13164023

    申请日：2011-06-20

    申请人： Gregory L. Snitchler ,  Timothy MacDonald

    发明人： Gregory L. Snitchler ,  Timothy MacDonald

    IPC分类号： F03D9/00 ,  H02K1/16

    CPC分类号： H02K1/165 ,  H02K7/1838 ,  H02K55/04 ,  H02K2213/03 ,  Y02E10/725 ,  Y02E40/625

    摘要： A stator assembly for use in a superconducting generator operated at frequencies up to 10 Hz is disclosed. The stator assembly includes a ferromagnetic stator winding support having a plurality of teeth defining slots, the slots configured to receive and support stator windings. The stator winding support is formed so that the ratio of the sum of the widths of the slots to the sum of the widths of the teeth and slots is in the range of 0.65 to 0.90.

    摘要翻译： 公开了用于在高达10Hz的频率下运行的超导发电机的定子组件。 定子组件包括铁磁定子绕组支撑件，其具有限定槽的多个齿，所述槽配置成接收和支撑定子绕组。 定子绕组支撑件形成为使得槽的宽度之和与齿和槽的宽度之和的比率在0.65至0.90的范围内。

    Gamma-glutamyl transpeptidase-specific antibody, prodrugs for the treatment of gamma-glutamyl transpeptidase-expressing tumors, and methods of administration thereof
    6.
    发明授权
    Gamma-glutamyl transpeptidase-specific antibody, prodrugs for the treatment of gamma-glutamyl transpeptidase-expressing tumors, and methods of administration thereof 失效
    γ-谷氨酰转肽酶特异性抗体，用于治疗表达γ-谷氨酰转肽酶的肿瘤的前药及其施用方法

    公开(公告)号：US5854006A

    公开(公告)日：1998-12-29

    申请号：US825349

    申请日：1997-03-28

    申请人： Marie Hanigan ,  Timothy MacDonald

    发明人： Marie Hanigan ,  Timothy MacDonald

    IPC分类号： C07K16/40 ,  C12N9/10 ,  G01N33/573 ,  G01N33/53 ,  C07K16/00

    CPC分类号： C12N9/104 ,  C07K16/40 ,  G01N33/573

    摘要： An antibody is provided which binds to active GGT, and can identify tissues which express GGT on their surface. Many solid tumors express GGT on their surface. Individuals identified with such tumors may be treated with inactivated prodrugs of chemotherapeutic agents at local dosage levels substantially above the maximum dosage levels currently permitted due to side effect limitations. The prodrugs are comprised of chemotherapeutic agents rendered inactive by the attachment of a gamma-glutamyl group thereto. The gamma-glutamyl group is cleaved by GGT on the surface of solid tumor cells expressing GGT, and thus active only locally against the tumor. Side effects are suppressed. The antibody is used to identify solid tumors that are candidates for this treatment, as well as to identify tissues which express GGT and which must therefore be the basis of selection criteria of various available chemotherapeutic agents.

    摘要翻译： 提供与活性GGT结合的抗体，并且可以鉴定表达GGT的组织。 许多实体瘤在其表面表达GGT。 用这些肿瘤鉴定的个体可以用局部剂量水平的化学治疗剂的灭活前药进行治疗，其实质上高于由于副作用限制而允许的最大剂量水平。 前药由通过连接γ-谷氨酰基而变得无活性的化学治疗剂组成。 γ-谷氨酰基在表达GGT的实体肿瘤细胞表面被GGT切割，因此仅在局部对抗肿瘤。 副作用被抑制。 该抗体用于鉴定作为该治疗的候选物的实体瘤，以及鉴定表达GGT的组织，因此必须是各种可用的化学治疗剂的选择标准的基础。

    2- and 3-Cyclotetradecen-1-ones as bitterness depressants
    8.
    发明授权
    2- and 3-Cyclotetradecen-1-ones as bitterness depressants 失效
    2-和3-环十四碳烯-1-酮作为苦味抑制剂

    公开(公告)号：US4183965A

    公开(公告)日：1980-01-15

    申请号：US973093

    申请日：1978-12-26

    申请人： Braja D. Mookherjee ,  Robert W. Trenkle ,  Manfred H. Vock ,  Domenick Luccarelli, Jr. ,  Frederick L. Schmitt ,  Gilbert Stork ,  Timothy MacDonald ,  Arthur L. Liberman

    发明人： Braja D. Mookherjee ,  Robert W. Trenkle ,  Manfred H. Vock ,  Domenick Luccarelli, Jr. ,  Frederick L. Schmitt ,  Gilbert Stork ,  Timothy MacDonald ,  Arthur L. Liberman

    IPC分类号： A23F5/46 ,  A23G3/00 ,  A23G3/36 ,  A23L27/20 ,  A23L27/30 ,  C07C45/56 ,  C07C49/587 ,  C11B9/00 ,  A23F1/04 ,  A23L1/22 ,  A23L1/226 ,  C12C3/00

    CPC分类号： A23G3/36 ,  A23F5/465 ,  A23L27/203 ,  A23L27/30 ,  C07C45/562 ,  C07C49/587 ,  C11B9/0038

    摘要： Processes and compositions are described for the use in foodstuff flavor and aroma and perfume and perfumed article aroma augmenting, modifying, altering and enhancing compositions and as foodstuffs, chewing gum, toothpaste, medicinal product, perfume and perfumed article aroma imparting materials of specific isomer and isomer mixtures of 2- and 3-cyclotetradecen-1-ones having the structures: ##STR1## or mixtures of same or mixtures of such 2- and 3-cyclotetradecen-1-ones with cyclotetradecanone having the structure: ##STR2## or cyclododecanone having the structure: ##STR3## Addition of said 2- and 3-cyclotetradecen-1-ones or mixtures is indicated to produce:(a) In food flavorings, a sweet, brown sugar and musky aroma and sweet and musky flavor characteristics (useful for flavor augmentation or enhancement in pear, blackberry, apricot and peach flavors and as a bitterness depressant for such foodstuffs, flavor adjuvants and beverages as black coffee; and(b) In perfumes and perfumed articles, a sweet, musk aroma and exaltone-like, scorched linen, waxy and rooty nuances.

    摘要翻译： 描述了用于食品香料和香料和香料和香料制品香气增强，改性，改变和增强组合物以及作为食品，口香糖，牙膏，药用产品，香料和香料赋予特定异构体的芳香赋予材料的方法和组合物， 具有以下结构的2-和3-环十四碳烯-1-酮的异构体混合物：或其混合物或这些2-和3-环十四碳烯-1-酮与环十四烷酮的混合物，其具有以下结构：具有以下结构： 结构：所述2-和3-环十四碳烯-1-酮或其混合物的添加表明产生：（a）在食品香料中，甜味，红糖和麝香的香气和甜味和麝香风味特征（可用于 梨，黑莓，杏子和桃子香味的香味增强或增强，以及作为黑咖啡的这类食品，风味佐剂和饮料的苦味抑制剂;和（b）在香水和香料中 一种甜美的麝香，麝香香气和高雅的香味，烧焦的亚麻，蜡质和根深蒂固的细微差别。

    Reduced-loss bucking bundle low voltage cable
    9.
    发明授权
    Reduced-loss bucking bundle low voltage cable 有权
    降损型降压束低压电缆

    公开(公告)号：US09012779B2

    公开(公告)日：2015-04-21

    申请号：US13435197

    申请日：2012-03-30

    申请人： Gregory L. Snitchler ,  Bruce B. Gamble ,  Glenn C. Driscoll ,  Timothy MacDonald

    发明人： Gregory L. Snitchler ,  Bruce B. Gamble ,  Glenn C. Driscoll ,  Timothy MacDonald

    IPC分类号： H01B7/00 ,  H01B12/02 ,  H01B7/30

    CPC分类号： H01B12/02 ,  H01B7/30 ,  Y02E40/641

    摘要： A cable includes a plurality of bundles of insulated electrical conductors, each bundle having a first conductor, a second conductor, and a third conductor in a layered configuration. The first conductor of each bundle is connected in parallel to the first conductor of the remaining bundles, the second conductor of each bundle is connected in parallel to the second conductor of the remaining bundles, and the third conductor of each bundle is connected in parallel to the third electrical conductor of the remaining bundles. In addition, within each bundle, the first, second and third electrical conductors are configured so that a magnetic field generated in response to currents flowing within the bundle is zero as seen at a plane oriented transverse to an electrical conduction direction of the cable and located between the ends of the cable.

    摘要翻译： 电缆包括多个绝缘电导体束，每个束具有分层构造的第一导体，第二导​​体和第三导体。 每个束的第一导体与剩余束的第一导体并联连接，每个束的第二导体与剩余束的第二导体并联连接，并且每个束的第三导体并联连接到 剩下的束的第三个电导体。 此外，在每个束内，第一，第二和第三电导体被构造成使得响应于在束内流动的电流产生的磁场为零，如在垂直于电缆的导电方向定向的平面所看到的， 在电缆的两端之间。

    REDUCED-LOSS BUCKING BUNDLE LOW VOLTAGE CABLE
    10.
    发明申请
    REDUCED-LOSS BUCKING BUNDLE LOW VOLTAGE CABLE 有权
    降低损耗电池组低压电缆

    公开(公告)号：US20130255991A1

    公开(公告)日：2013-10-03

    申请号：US13435197

    申请日：2012-03-30

    申请人： Gregory L. Snitchler ,  Bruce B. Gamble ,  Glenn C. Driscoll ,  Timothy MacDonald

    发明人： Gregory L. Snitchler ,  Bruce B. Gamble ,  Glenn C. Driscoll ,  Timothy MacDonald

    IPC分类号： H01B7/00

    CPC分类号： H01B12/02 ,  H01B7/30 ,  Y02E40/641

    摘要： A cable includes a plurality of bundles of insulated electrical conductors, each bundle having a first conductor, a second conductor, and a third conductor in a layered configuration. The first conductor of each bundle is connected in parallel to the first conductor of the remaining bundles, the second conductor of each bundle is connected in parallel to the second conductor of the remaining bundles, and the third conductor of each bundle is connected in parallel to the third electrical conductor of the remaining bundles. In addition, within each bundle, the first, second and third electrical conductors are configured so that a magnetic field generated in response to currents flowing within the bundle is zero as seen at a plane oriented transverse to an electrical conduction direction of the cable and located between the ends of the cable.

    摘要翻译： 电缆包括多个绝缘电导体束，每个束具有分层构造的第一导体，第二导​​体和第三导体。 每个束的第一导体与剩余束的第一导体并联连接，每个束的第二导体与剩余束的第二导体并联连接，并且每个束的第三导体并联连接到 剩下的束的第三个电导体。 此外，在每个束内，第一，第二和第三电导体被构造成使得响应于在束内流动的电流产生的磁场为零，如在垂直于电缆的导电方向定向的平面所看到的， 在电缆的两端之间。