公开(公告)号：US4797563A

公开(公告)日：1989-01-10

申请号：US77358

申请日：1987-07-24

Applicant: Timothy M. Richardson

Inventor： Timothy M. Richardson

IPC: F02C3/00 ,  F02C6/16 ,  F04F5/18 ,  F02C3/12

CPC classification number: F02C6/16 ,  F02C3/00 ,  F04F5/18 ,  Y02E60/15

Abstract: Electrical power is generated by means of an hydraulic air compressor that produces compressed air from a water stream. The compressed air is delivered directly to burners of a turbine without significant additional compression and after preheating using waste heat from the turbine exhaust. The turbine is used to drive a conventional electrical generator for producing power.

Abstract translation: 通过从水流产生压缩空气的液压空气压缩机产生电力。 压缩空气直接输送到涡轮机的燃烧器，而没有显着的附加压缩，并且在使用来自涡轮排气的废热进行预热之后。 涡轮机用于驱动用于产生动力的常规发电机。

公开(公告)号：US06381013B1

公开(公告)日：2002-04-30

申请号：US08882491

申请日：1997-06-25

Applicant: Timothy M. Richardson

Inventor： Timothy M. Richardson

IPC: G01J110

CPC classification number: H01J37/20 ,  G01N2001/2893 ,  G02B21/34

Abstract: A test slide for the calibration, characterization, standardization, use and study of photon and electron microscopes. The slide is created by forming patterns with specific types of geometries on suitable substrates and these slides provide a standard for comparison of image forming capability of any type of microscope imaging system including, without limitation, light, UV, and X-ray photon microscopical imaging systems operating in transmission or reflection modes, and other microscope techniques. Microscopists can employ one of these slides to compare images of the slide which have been produced by the microscope system under consideration with a known, accurate, image of the slide to better understand the fidelity and accuracy of the microscope system under consideration. The test patterns can also comprise reference images which can be images created by a graphic artist or the like or which can be actual images of samples, these images being either two dimensional or three dimensional.

Abstract translation: 用于光子和电子显微镜的校准，表征，标准化，使用和研究的测试幻灯片。 通过在合适的基底上形成具有特定类型几何形状的图案来创建幻灯片，并且这些幻灯片提供用于比较任何类型的显微镜成像系统的图像形成能力的标准，包括但不限于光，UV和X射线光子显微镜成像 以透射或反射模式运行的系统，以及其他显微镜技术。 显微镜学家可以使用这些幻灯片之一来比较由考虑的显微镜系统产生的幻灯片的图像与幻灯片的已知准确的图像，以更好地理解所考虑的显微镜系统的保真度和准确度。 测试图案还可以包括参考图像，其可以是由图形艺术家等创建的图像，或者可以是样本的实际图像，这些图像是二维或三维的。

公开(公告)号：US06650357B1

公开(公告)日：2003-11-18

申请号：US09402467

申请日：1999-12-23

Applicant: Timothy M. Richardson

Inventor： Timothy M. Richardson

IPC: H04N718

CPC classification number: G01N21/65 ,  G01J3/10 ,  G01J3/32 ,  G01J3/36 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6423 ,  G01N2021/656 ,  G02B21/16 ,  H04N9/47

Abstract: A color translating UV or IR microscope for imaging living or dynamic samples in real time. The microscope includes a UV or IR light source and a first filter for cyclically separating light from the light source into spectral components which illuminate the sample. A device such as an image intensifier converts light received from the sample to visible polychromatic light, e.g., an intensified white light. A second filter set separates the visible polychromatic light into color planes. The first and second filter sets are synchronized with each other so as to enable the color planes to be recombined into a visible multicolor image, wherein each color plane represents illumination of the sample by non-visible light of different wavelengths.

Abstract translation: 用于实时成像生活或动态样品的彩色平移UV或IR显微镜。 显微镜包括UV或IR光源和用于将来自光源的光循环地分离成照射样品的光谱分量的第一滤光器。 诸如图像增强器的装置将从样品接收的光转换成可见的多色光，例如增强的白光。 第二过滤器组将可见多色光分离成彩色平面。 第一和第二滤波器组彼此同步，以使得可以将色彩平面重新组合成可见的多色图像，其中每个彩色平面通过不同波长的不可见光表示样品的照明。

公开(公告)号：US6052224A

公开(公告)日：2000-04-18

申请号：US870242

申请日：1997-06-05

Applicant: Timothy M. Richardson

Inventor： Timothy M. Richardson

IPC: B01L3/00 ,  G02B21/34 ,  G01N21/01

CPC classification number: G02B21/34 ,  B01L3/508 ,  B01L2300/0822 ,  B01L2300/0877 ,  Y10T436/25

Abstract: A slide system allowing rapid, sterile, clean and safe preparation and use of microscope slides containing sample materials including living and/or hazardous preparations or samples. In one embodiment, the system comprises a slide base and cover slip which are preferably pre-cleaned and supplied in a sterile wrapper. The cover slip, slide base or both have an adhesive coating that surrounds a sample area to adhere the cover slip to the slide base, thereby creating a sealed sample area or chamber that is defined by the slide, the cover slip, and the adhesive. In another embodiment, the slide base has one or two grooves or depressions in the surface of the slide base positioned within the sample area, the grooves or depressions accommodating extra or expanding sample material to prevent loss of the sample material into the environment and prevent damage to the adhesive and/or cover slip. A layer of an active element, such as a neutralizing compound, can be provided to neutralize sample materials before they escape past the adhesive. The wrapper is designed to facilitate easy handling and to permit convenient and easy mounting of sample material into the slide.

Abstract translation: 一种允许快速，无菌，清洁和安全的制备和使用含有生物和/或危险制剂或样品的样品材料的显微镜载片的载玻片系统。 在一个实施例中，系统包括滑动基座和盖子滑动件，其优选地被预先清洁并且在无菌包装件中提供。 盖板滑动件，滑动底座或两者具有围绕样品区域的粘合剂涂层，以将盖板粘合到滑动基部，从而形成由滑块，盖滑动件和粘合剂限定的密封样品区域或室。 在另一个实施例中，滑动基座在滑动基座的表面中具有位于样品区域内的一个或两个凹槽或凹陷，凹槽或凹陷容纳额外或膨胀的样品材料，以防止样品材料损失到环境中并防止损坏 粘合剂和/或盖板滑动。 可以提供一层活性元素，例如中和化合物，以在试样材料逸出粘合剂之前中和样品。 包装纸被设计成便于操作，并且允许将样品材料方便和容易地安装到载玻片中。

公开(公告)号：US07262419B2

公开(公告)日：2007-08-28

申请号：US11122238

申请日：2005-05-05

Applicant: Timothy M. Richardson

Inventor： Timothy M. Richardson

IPC: G01N21/64

CPC classification number: G01N21/6458 ,  G01N2021/6471 ,  G01N2021/6491

Abstract: A microscopy technique for viewing regions where a sample absorbs, as opposed to emits, fluorescent light. The technique includes illuminating a sample with an exciter light in order to generate fluorescent light from the sample and filtering light received from the sample such that fluorescent light is substantially attenuated. Regions that primarily emit fluorescent light will then be black, but regions where the exciter is primarily absorbed but where there is little emissive fluorescent activity can be viewed as a darker shade of the background color.

Abstract translation: 用于观察样品吸收的区域的显微技术，而不是发射荧光。 该技术包括用激发光照射样品，以便产生来自样品的荧光，并过滤从样品接收的光，使得荧光基本上被衰减。 主要发射荧光的区域将是黑色的，但是激发器主要被吸收的地方，但是发射荧光活性很小的区域可以被视为背景颜色的较深的阴影。

公开(公告)号：US07085044B2

公开(公告)日：2006-08-01

申请号：US10736751

申请日：2003-12-17

Applicant: Timothy M. Richardson

Inventor： Timothy M. Richardson

IPC: G02B21/00 ,  G02B21/26

CPC classification number: G02B21/24 ,  G02B21/0088 ,  G02B21/02 ,  G02B21/10 ,  G02B21/362 ,  G02B21/365 ,  G02B27/0018

Abstract: A microscope having a pair of braces connecting a head portion, carrying an objective, to the base, to which a stage is attached. The braces, which preferably have resonant frequency that is not a harmonic or sub-harmonic of the fundamental frequency of vibration of the C-shaped frame, function to reduce vibration and enhance the clarity of the image viewed through the objective. In one embodiment, the length of the braces along a vertical optical axis of the microscope can be adjusted to provide very fine focusing control.

Abstract translation: 显微镜具有将一个带有目标的头部连接到基座的一对支架，一个台架被安装到该支架上。 优选地，具有不是C形框架的基本振动频率的谐波或次谐波的谐振频率的支架用于减少振动并增强通过物镜观看的图像的清晰度。 在一个实施例中，可以调整沿着显微镜的垂直光轴的支架的长度以提供非常精细的聚焦控制。

公开(公告)号：US06751516B1

公开(公告)日：2004-06-15

申请号：US09635922

申请日：2000-08-10

Applicant: Timothy M. Richardson

Inventor： Timothy M. Richardson

IPC: G06F1900

CPC classification number: B22F3/1055 ,  B29C64/153 ,  Y02P10/295

Abstract: A method and apparatus for creating three dimensional solid forms in metals, ceramics, organics or any combination thereof is made possible using a computer controlled system to create local environmental conditions that favor deposition from a material stream, precursor gas, weld process or plasma. In order to increase control and accuracy, the material can also be placed while the target area is monitored by a broadband poly-spectral imaging system, which provides dimensional, geometrical, chemical composition, stress and temperature feedback to the computer controlling the process. The local environmental conditions in the deposition area are controlled for magnetic, electric, and acoustic fields as well as for temperature, pressure, flow dynamics, and atmospheric composition. Complex materials can be “written” to match a computer's file of a three dimensional shape with virtually any material composition, surface finish, and geometrical complexity. Discrete components, such as microspheres, optical, electronic or any other components or materials that do not lend themselves to the deposition process, can be inserted and the shape written around them to make them an integral part of the final form. While the system can “write” a three-dimensional shape it can also be used to “erase” some or all of a shape. The environmental conditions can also be changed so that material can be removed under computer controlled so that any corrections or final features can be created including such operations as final polishing or surface finishing. The digital files containing the three-dimensional image, environmental and compositional data can be sent to remote locations where the data can be used to write a new three dimensional object.

Abstract translation: 使用计算机控制的系统可以实现用于在金属，陶瓷，有机物或其任何组合中产生三维固体形式的方法和装置，以产生有利于从材料流，前体气体，焊接工艺或等离子体沉积的局部环境条件。 为了增加控制和准确性，也可以通过宽带多光谱成像系统来监测目标区域，从而为控制过程的计算机提供尺寸，几何，化学组成，应力和温度反馈，从而可以放置材料。 对于磁场，电场和声场以及温度，压力，流动动力学和大气成分，对沉积区域的局部环境条件进行控制。 复杂的材料可以“写成”以匹配计算机的三维形状的文件，几乎具有任何材料组成，表面光洁度和几何复杂性。 可以插入离散组分，例如微球，光学，电子或任何不适合沉积过程的其它组分或材料，并且将它们写入周围形状，使其成为最终形式的组成部分。 虽然系统可以“写”三维形状，但也可以用于“擦除”一些或全部形状。 环境条件也可以改变，以便在计算机控制下可以移除材料，以便可以创建任何修正或最终特征，包括最终抛光或表面抛光等操作。 包含三维图像，环境和组成数据的数字文件可以发送到远程位置，数据可以用于写入新的三维物体。

公开(公告)号：US06704140B1

公开(公告)日：2004-03-09

申请号：US09743222

申请日：2001-04-11

Applicant: Timothy M. Richardson

Inventor： Timothy M. Richardson

IPC: G02B2106

CPC classification number: G02B21/24 ,  G02B21/0088 ,  G02B21/02 ,  G02B21/10 ,  G02B21/362 ,  G02B21/365 ,  G02B27/0018

Abstract: A novel microscope and method of obtaining images includes a combination of the conventional darkfield illumination technique with electronic image inversion (converting a positive to a negative image) and other improvements to further enhance the contrast and resolution of the final image. The microscope and method are referred to herein as Inverted Darkfield Contrast (IDC) and are believed to be particularly suitable for viewing live cells in real time with no staining or preparation.

Abstract translation: 获得图像的新型显微镜和方法包括常规暗场照明技术与电子图像反转（将正转换成负像）和其他改进的组合，以进一步增强最终图像的对比度和分辨率。 显微镜和方法在本文中称为倒置暗场对比度（IDC），并且被认为特别适用于实时观察活细胞而无染色或制备。