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18 条记录 (耗时 0.05 秒)

    Calcium receptor modulating compound and use thereof
    1.
    发明申请
    Calcium receptor modulating compound and use thereof 有权
    钙受体调节化合物及其用途

    公开(公告)号：US20060079536A1

    公开(公告)日：2006-04-13

    申请号：US10525158

    申请日：2003-08-21

    申请人： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Gyorkos ,  Scott Pratt ,  Christopher Corrette

    发明人： Tsuneo Yasuma ,  Akira Mori ,  Masahiro Kawase ,  Hiroyuki Kimura ,  Masato Yoshida ,  Albert Gyorkos ,  Scott Pratt ,  Christopher Corrette

    IPC分类号： A61K31/519 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7-membered ring; ring B is an optionally substituted 5- to 7-membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7-membered ring; Q is C, CR5 or N; R8, R9, R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.

    摘要翻译： 提供了包含式（I）化合物的钙受体调节剂：其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X 1是CR 1，CR 1，R 2，N或NR 13， ; X 2是N或NR 3; Y是C，CR 4或N，Z是CR 5，CR 5，R 6，N或NR 7 ; Ar是任选取代的环状基团; R为H，任选取代的烃基等; “img id =”custom-character-00001“he =”1.78mm“wi =”2.12mm“file =”US20060079536A1-20060413-P00001.TIF“alt =”custom character“img-content =”character“img- format =“tif”/>是单键或双键; R 1，R 2，R 3，R 4，R 5， R 6，R 7和R 13独立地是H，任选取代的烃基; 或其盐或其前药。 式（II）和（III）的化合物：其中环A是任选取代的5-至7-元环; Q是C，CR 5或N; R 9，R 9，R 10，R 11和R 12都是 还可以提供H，任选取代的烃基等，或其盐。 还可以在式（II）中指定X 1，R 3，R 3，R 3，Y和X 3，和（ III）。

    Gene expression in transgenic avians
    6.
    发明申请
    Gene expression in transgenic avians 审中-公开
    转基因鸟类中的基因表达

    公开(公告)号：US20070009991A1

    公开(公告)日：2007-01-11

    申请号：US11516357

    申请日：2006-09-06

    申请人： Nelson Horseman ,  Scott Pratt

    发明人： Nelson Horseman ,  Scott Pratt

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N15/86 ,  C12N5/06 ,  C07K14/47

    CPC分类号： C12Q1/6806 ,  A01K2217/05 ,  A01K2227/30 ,  A01K2267/01 ,  A01K2267/02 ,  C12N15/8509 ,  C12N2830/008 ,  C12Q2547/101 ,  C12Q2527/137 ,  C12Q2527/125

    摘要： A recombinant nucleic acid is provided having an avian promoter. One embodiment of the present invention contemplates the use of a gut-specific promoter, wherein a promoter can be the chicken intestinal fatty acid binding protein promoter region. A method for making a transgenic bird is also disclosed by transfecting a bird with a vector comprising a recombinant nucleic acid comprising a chicken intestinal fatty acid binding protein promoter region operably linked to a heterologous nucleic acid expressing a desired polypeptide to be expressed in the gut tissue of an avian.

    摘要翻译： 提供了具有鸟类启动子的重组核酸。 本发明的一个实施方案考虑使用肠特异性启动子，其中启动子可以是鸡肠道脂肪酸结合蛋白启动子区。 通过用包含重组核酸的载体转染鸟来披露转基因鸟的方法，所述载体包含与表达欲在肠组织中表达的所需多肽的异源核酸可操作地连接的鸡肠道脂肪酸结合蛋白启动子区 的禽鸟

    Autonomous surface cleaning robot for wet and dry cleaning
    9.
    发明申请
    Autonomous surface cleaning robot for wet and dry cleaning 审中-公开
    自动清洗机器人，用于干洗和干洗

    公开(公告)号：US20060200281A1

    公开(公告)日：2006-09-07

    申请号：US11134212

    申请日：2005-05-21

    申请人： Andrew Ziegler ,  Duane Gilbert ,  Christopher Morse ,  Scott Pratt ,  Paul Sandin ,  Nancy Dussault ,  Andrew Jones

    发明人： Andrew Ziegler ,  Duane Gilbert ,  Christopher Morse ,  Scott Pratt ,  Paul Sandin ,  Nancy Dussault ,  Andrew Jones

    IPC分类号： G06F19/00

    CPC分类号： A47L11/4083 ,  A47L11/302 ,  A47L11/34 ,  A47L11/4011 ,  A47L11/4061 ,  A47L11/4072 ,  A47L2201/00

    摘要： An autonomous floor cleaning robot includes a transport drive and control system arranged for autonomous movement of the robot over a floor for performing cleaning operations. The robot chassis carries a first cleaning zone comprising cleaning elements arranged to suction loose particulates up from the cleaning surface and a second cleaning zone comprising cleaning elements arraigned to apply a cleaning fluid onto the surface and to thereafter collect the cleaning fluid up from the surface after it has been used to clean the surface. The robot chassis carries a supply of cleaning fluid and a waste container for storing waste materials collected up from the cleaning surface.

    摘要翻译： 自动地板清洁机器人包括传送驱动和控制系统，其被布置成用于机器人在地板上的自动运动以执行清洁操作。 所述机器人机架包括第一清洁区域，所述第一清洁区域包括布置成从所述清洁表面向上抽吸松散颗粒的清洁元件，以及第二清洁区域，所述第二清洁区域包括被清理的清洁元件，以将清洁流体施加到所述表面上， 它已被用来清洁表面。 机器人底盘运送清洁液供应源和用于储存从清洁表面收集的废物的废物容器。