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公开(公告)号：US10155177B2
公开(公告)日：2018-12-18
申请号：US14747074
申请日：2015-06-23
Applicant: Waters Technologies Corporation
Inventor： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson , Gary W. Bertone
Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.
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公开(公告)号：US20150290644A1
公开(公告)日：2015-10-15
申请号：US14747074
申请日：2015-06-23
Applicant: Waters Technologies Corporation
Inventor： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson , Gary W. Bertone
IPC: B01L3/00
CPC classification number: B01D15/10 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0883 , B05B1/00 , B05B1/02 , G01N27/44791 , G01N30/6095 , G01N30/72 , G01N30/7233 , G01N30/724 , G01N30/7266 , H01J49/167 , Y10T137/598 , Y10T436/24
Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.
Abstract translation: 液相色谱模块包括容纳具有用于输送流体的通道的微流体基板的微流体盒。 微流体衬底具有流体孔，通道将流体供应到通道。 墨盒的一侧具有喷嘴开口，每个与微流体基板中的流体孔对准并且接收流体喷嘴。 夹紧组件具有可移动到夹紧位置的柱塞和限定腔室的端部壳体。 端部壳体的一个壁具有流体块，流体喷嘴延伸到腔室中。 第二壁具有狭槽，盒通过该槽进入腔室。 当墨盒在腔室中移动到夹紧位置时，柱塞将墨盒推向流体块，使得每个流体喷嘴进入一个喷嘴开口并且与微流体衬底中的一个流体孔隙建立流体连通。
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公开(公告)号：US20140319042A1
公开(公告)日：2014-10-30
申请号：US14273040
申请日：2014-05-08
Applicant: Waters Technologies Corporation
Inventor： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson
CPC classification number: B01D15/10 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0883 , B05B1/00 , B05B1/02 , G01N27/44791 , G01N30/6095 , G01N30/72 , G01N30/7233 , G01N30/724 , G01N30/7266 , H01J49/167 , Y10T137/598 , Y10T436/24
Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.
Abstract translation: 一种用于化学分离的装置包括具有用于输出样品洗脱液的出口孔的微流体衬底，具有用于接收洗脱液的入口的喷雾单元和用于喷射洗脱液的出口以及施力单元。 喷射单元具有限定入口的可变形部分，并且具有低于微流体衬底的弹性模量的弹性模量。 力施加单元（例如弹簧）被设置成推动与基底接触的可变形部分以形成基本上流体密封的密封。
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公开(公告)号：US09242192B2
公开(公告)日：2016-01-26
申请号：US14273040
申请日：2014-05-08
Applicant: Waters Technologies Corporation
Inventor： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson
CPC classification number: B01D15/10 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0883 , B05B1/00 , B05B1/02 , G01N27/44791 , G01N30/6095 , G01N30/72 , G01N30/7233 , G01N30/724 , G01N30/7266 , H01J49/167 , Y10T137/598 , Y10T436/24
Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.
Abstract translation: 一种用于化学分离的装置包括具有用于输出样品洗脱液的出口孔的微流体衬底，具有用于接收洗脱液的入口的喷雾单元和用于喷射洗脱液的出口以及施力单元。 喷射单元具有限定入口的可变形部分，并且具有低于微流体衬底的弹性模量的弹性模量。 力施加单元（例如弹簧）被设置成推动与基底接触的可变形部分以形成基本上流体密封的密封。
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