公开(公告)号：US11874256B2

公开(公告)日：2024-01-16

申请号：US17471449

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Thomas H. Walter ,  Matthew A. Lauber ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/16 ,  G01N30/72 ,  G01N30/74 ,  G01N30/86 ,  G01N30/06 ,  G01N30/02

CPC classification number: G01N30/16 ,  G01N30/72 ,  G01N30/74 ,  G01N30/8637 ,  G01N30/06 ,  G01N2030/027

Abstract: The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.

公开(公告)号：US20220091076A1

公开(公告)日：2022-03-24

申请号：US17484157

申请日：2021-09-24

Applicant: Waters Technologies Corporation

Inventor： Mathew DeLano ,  Matthew A. Lauber ,  Kevin Wyndham ,  Jennifer M. Nguyen

IPC: G01N30/60 ,  C23C16/02 ,  C23C16/04 ,  C23C16/26

Abstract: The present disclosure relates to a method of reducing degradation of sample components in a liquid chromatography system. The method utilizes a masked metal frit to prevent or reduce metal surfaces from becoming catalytically active. The masked metal frit is a metal based frit that includes a coating on its exterior surfaces to mask or prevent contact between the organic solvents (and/or any analyte or other related solvent) and the underlying metal. The coating is a vapor deposited inorganic-organic hybrid coating, such as a vapor deposited C2 coating.

公开(公告)号：US20220091079A1

公开(公告)日：2022-03-24

申请号：US17471463

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Susan Rzewuski ,  Matthew A. Lauber ,  Thomas H. Walter ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/88

Abstract: The present disclosure is directed to a kit for evaluating system inertness. The kit includes a positive control comprising a metal interacting moiety, and a negative control that does not contain a metal interacting moiety. In some embodiments the kit also includes a container to hold a system suitability solution (e.g., an equimolar mixture of the positive control and the negative control).

公开(公告)号：US20220082531A1

公开(公告)日：2022-03-17

申请号：US17471393

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Susan Rzewuski ,  Thomas H. Walter ,  Matthew A. Lauber ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/04

Abstract: The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.

公开(公告)号：US11511213B2

公开(公告)日：2022-11-29

申请号：US15752121

申请日：2016-08-12

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Hua Yang ,  Edouard S. P. Bouvier ,  Mathew DeLano ,  Raymond P. Fisk ,  Hillary B. Hewitson ,  Wade P. Leveille ,  Kevin Daniel Wyndham

IPC: B01D15/22 ,  G01N30/60 ,  B01D53/02 ,  C12M1/40 ,  C12M1/00 ,  B01L3/00 ,  G01N30/72 ,  G01N30/88

Abstract: Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

公开(公告)号：US20220082532A1

公开(公告)日：2022-03-17

申请号：US17471449

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Susan Rzewuski ,  Thomas H. Walter ,  Matthew A. Lauber ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/16 ,  G01N30/86 ,  G01N30/72 ,  G01N30/74

Abstract: The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.

公开(公告)号：US20180236379A1

公开(公告)日：2018-08-23

申请号：US15752121

申请日：2016-08-12

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Hua Yang ,  Edouard S.P. Bouvier ,  Mathew DeLano ,  Raymond P. Fisk ,  Hillary B. Hewitson ,  Wade P. Leveille ,  Kevin Daniel Wyndham

IPC: B01D15/22 ,  G01N30/60 ,  C12M1/40 ,  C12M1/00

CPC classification number: B01D15/22 ,  B01D53/02 ,  B01D53/025 ,  B01D2253/1122 ,  B01L3/502753 ,  C12M21/18 ,  C12M23/20 ,  G01N30/6052 ,  G01N30/6073 ,  G01N30/6095 ,  G01N30/7266 ,  G01N2030/8831

Abstract: Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.