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公开(公告)号：US20230125093A1
公开(公告)日：2023-04-27
申请号：US17970874
申请日：2022-10-21
发明人： Matthew A. Lauber , Kevin Wyndham , Szabolcs Fekete , Hua Yang , Stephan Koza
IPC分类号： C12N15/10
摘要： The present invention relates to a method for separating a sample comprising a nucleic acid, the method comprising: (a) loading a sample comprising a nucleic acid onto an anion-exchange column; and (b) eluting the sample from the anion-exchange column using a salt gradient, wherein a mobile phase used in the eluting step comprises a mild ion-pairing cation, and wherein a column temperature of the anion-exchange column is greater than 30° C. The present invention also relates to a method for determining one or more calorimetric properties of a nucleic acid using anion-exchange chromatography.
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公开(公告)号：US20180140971A1
公开(公告)日：2018-05-24
申请号：US15874469
申请日：2018-01-18
发明人： Moon Chul Jung , Hua Yang , Edouard S.P. Bouvier
IPC分类号： B01D15/22 , B01J20/28 , B01D15/10 , B01D15/08 , B01D15/18 , B32B5/02 , B32B3/26 , B32B1/02 , B01J35/10 , B01D15/38 , B01J20/32 , B01J20/285 , B01J20/26 , B01D15/34
CPC分类号： B01D15/22 , B01D15/08 , B01D15/10 , B01D15/18 , B01D15/34 , B01D15/3804 , B01J20/262 , B01J20/264 , B01J20/28 , B01J20/28007 , B01J20/28014 , B01J20/28042 , B01J20/28088 , B01J20/285 , B01J20/3212 , B01J20/3268 , B01J35/108 , B01J2220/82 , B01J2220/86 , B32B1/02 , B32B3/26 , B32B5/02 , Y10T428/1321 , Y10T428/1352 , Y10T428/1376 , Y10T428/249978
摘要： Embodiments of the present invention are directed to a porous monolith polymeric composition having utility in catalysis, chromatography, filtration, and electro-kinetic pumps, devices incorporating such composition and methods or making and using such monoliths. The monoliths are characterized by a substantially homogeneous skeletal core with little shrinkage, few voids and few channels.
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公开(公告)号：US11511213B2
公开(公告)日：2022-11-29
申请号：US15752121
申请日：2016-08-12
发明人： Jonathan L. Belanger , Hua Yang , Edouard S. P. Bouvier , Mathew DeLano , Raymond P. Fisk , Hillary B. Hewitson , Wade P. Leveille , Kevin Daniel Wyndham
摘要： Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.
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公开(公告)号：US20210382021A1
公开(公告)日：2021-12-09
申请号：US17335539
申请日：2021-06-01
发明人： Stephan M. Koza , Pamela Iraneta , Hua Yang
摘要： Described herein are systems and methods used for carrying out a two-dimensional liquid chromatography process using size exclusion chromatography as a first dimension.
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公开(公告)号：US10279283B2
公开(公告)日：2019-05-07
申请号：US15874469
申请日：2018-01-18
发明人： Moon Chul Jung , Hua Yang , Edouard S. P. Bouvier
IPC分类号： B01D15/22 , B32B5/02 , B01J20/28 , B01D15/10 , B01D15/08 , B01D15/18 , B01D15/34 , B01J20/283 , B01J20/26 , B01J20/285 , B01J20/32 , B01D15/38 , B01J35/10 , B32B1/02 , B32B3/26
摘要： Embodiments of the present invention are directed to a porous monolith polymeric composition having utility in catalysis, chromatography, filtration, and electro-kinetic pumps, devices incorporating such composition and methods or making and using such monoliths. The monoliths are characterized by a substantially homogeneous skeletal core with little shrinkage, few voids and few channels.
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公开(公告)号：US20180236379A1
公开(公告)日：2018-08-23
申请号：US15752121
申请日：2016-08-12
发明人： Jonathan L. Belanger , Hua Yang , Edouard S.P. Bouvier , Mathew DeLano , Raymond P. Fisk , Hillary B. Hewitson , Wade P. Leveille , Kevin Daniel Wyndham
CPC分类号： B01D15/22 , B01D53/02 , B01D53/025 , B01D2253/1122 , B01L3/502753 , C12M21/18 , C12M23/20 , G01N30/6052 , G01N30/6073 , G01N30/6095 , G01N30/7266 , G01N2030/8831
摘要： Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.
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