公开(公告)号：US20180147233A1

公开(公告)日：2018-05-31

申请号：US15873998

申请日：2018-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI

IPC: A61K31/7105 ,  C12Q1/6883 ,  A61K31/713 ,  C12N15/113 ,  A61K48/00

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K48/0058 ,  C12N15/113 ,  C12N2310/141 ,  C12Q1/6883 ,  C12Q2600/178

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.

公开(公告)号：US20220220559A1

公开(公告)日：2022-07-14

申请号：US17611149

申请日：2020-05-13

Applicant: Yeda Research And Development Co. Ltd. ,  Queen Mary University London ,  UCL Business Ltd

Inventor： Eran HORNSTEIN ,  Iddo MAGEN ,  Andrea MALASPINA ,  Pietro FRATTA

IPC: C12Q1/6883 ,  G01N33/50 ,  G01N33/68 ,  A61K31/428 ,  A61K31/4152 ,  A61P25/28

Abstract: A method of prognosing a course of disease progression and/or survival time in a subject diagnosed with ALS or FTD is disclosed. The method comprising: (a) detecting a level of miR-181 in a biological sample of the subject; and (b) determining the disease progression and/or survival time based on the level of the miR-181, wherein: (i) when the level of miR-181 is higher than that in a control sample, it is indicative of a rapid disease progression and/or poor survival; or (ii) when the level of miR-181 is about the same or lower than that in the control sample, it is indicative of a slow disease progression and/or good survival. Methods of prognosing a stage of disease in a subject diagnosed with ALS or FTD are also disclosed.

公开(公告)号：US20170009211A1

公开(公告)日：2017-01-12

申请号：US15278102

申请日：2016-09-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Sharon KREDO-RUSSO

IPC: C12N5/071 ,  C07K14/62 ,  C12N15/113

CPC classification number: C12N5/0676 ,  A61K31/7088 ,  A61K35/39 ,  C07K14/62 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2501/65

Abstract: A method of ex-vivo increasing insulin content in beta cells or stem cells is disclosed. The method comprising contacting the beta cells or stem cells with an agent for downregulating an activity or expression of miR-7, thereby increasing the insulin content in the beta cells or stem cells.

Abstract translation: 公开了一种离体增加β细胞或干细胞中胰岛素含量的方法。 该方法包括使β细胞或干细胞与用于下调miR-7的活性或表达的试剂接触，从而增加β细胞或干细胞中的胰岛素含量。

公开(公告)号：US20220364175A1

公开(公告)日：2022-11-17

申请号：US17846157

申请日：2022-06-22

Applicant: Yeda Research and Development Co. Ltd. ,  UCL Business Ltd

Inventor： Eran HORNSTEIN ,  Iddo MAGEN ,  Nancy-Sarah YACOVZADA ,  Jonathan ROHRER ,  Pietro FRATTA

IPC: C12Q1/6883 ,  G01N33/68

Abstract: A method of diagnosing Frontotemporal dementia (FTD) in a subject in need thereof is provided. The method comprising detecting a level of at least one micro RNA (miR) selected from the group consisting of hsa-miR-361-5p, hsa-miR-629-5p, hsa-miR-628-3p, hsa-miR-379-5p, hsa-miR-1-3p, hsa-miR-26a-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-142-5p and hsa-miR-340-5p in a biological sample of the subject, wherein when said level of said at least one micro RNA (miR) is higher than that in a control sample, it is indicative of FTD.

公开(公告)号：US20210369761A1

公开(公告)日：2021-12-02

申请号：US17391125

申请日：2021-08-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Irit REICHENSTEIN ,  Alon CHEN

IPC: A61K31/7105 ,  C12N15/113 ,  A61K45/06 ,  A61P25/00

Abstract: A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.

公开(公告)号：US20150197810A1

公开(公告)日：2015-07-16

申请号：US14671848

申请日：2015-03-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Alon Chen ,  Irit Reichenstein ,  Anna Maria Emde

IPC: C12Q1/68 ,  C12N15/113

CPC classification number: C12Q1/6883 ,  A61K31/7088 ,  C12N15/113 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: A method of diagnosing Amyotrophic Lateral Sclerosis (ALS) is disclosed. The method comprising determining a level of miR-218 in a biological sample of a subject, wherein a down-regulation in the miR-218 is indicative of ALS in the subject.

Abstract translation: 公开了诊断肌萎缩性侧索硬化症（ALS）的方法。 该方法包括测定受试者生物样品中miR-218的水平，其中miR-218中的下调表示受试者中的ALS。

公开(公告)号：US20220265696A1

公开(公告)日：2022-08-25

申请号：US17734199

申请日：2022-05-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI ,  Naama VOLK

IPC: A61K31/7105 ,  A61K31/713 ,  C12Q1/6883 ,  C12N15/113 ,  A61K48/00

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.

公开(公告)号：US20190167712A1

公开(公告)日：2019-06-06

申请号：US16273215

申请日：2019-02-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI ,  Naama VOLK

IPC: A61K31/7105 ,  A61K31/713 ,  A61K48/00 ,  C12Q1/6883 ,  C12N15/113

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.

公开(公告)号：US20160000821A1

公开(公告)日：2016-01-07

申请号：US14856697

申请日：2015-09-17

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI ,  Naama VOLK

IPC: A61K31/7105 ,  C12Q1/68 ,  A61K48/00

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K48/0058 ,  C12N15/113 ,  C12N2310/141 ,  C12Q1/6883 ,  C12Q2600/178

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.

Abstract translation: 提供了包含其的微小RNA和组合物，用于治疗和诊断5-羟色胺，肾上腺素，去甲肾上腺素，谷氨酸和促肾上腺皮质激素释放激素相关的医疗条件。

公开(公告)号：US20140243393A1

公开(公告)日：2014-08-28

申请号：US14277825

申请日：2014-05-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Alon Chen ,  Sharon Haramati ,  Elik Chapnik

IPC: C12N15/113

CPC classification number: C12N15/113 ,  A61K31/7088

Abstract: Use of an agent which upregulates an activity or amount of miRNA-9 or miRNA-9* is disclosed for the preparation of a medicament for the treatment of a motor neuron disease (MND).

Abstract translation: 公开了用于制备用于治疗运动神经元疾病（MND）的药物的上调miRNA-9或miRNA-9 *的活性或量的药剂的用途。