公开(公告)号：US09943401B2

公开(公告)日：2018-04-17

申请号：US12384659

申请日：2009-04-06

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  Yair Alster ,  David Sierra ,  Hanson S. Gifford ,  Jose D. Alejandro ,  Richard L. Lindstrom ,  K. Angela Macfarlane ,  Douglas Sutton ,  John Anthony Scholl

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  Yair Alster ,  David Sierra ,  Hanson S. Gifford ,  Jose D. Alejandro ,  Richard L. Lindstrom ,  K. Angela Macfarlane ,  Douglas Sutton ,  John Anthony Scholl

IPC分类号： A61F2/14 ,  A61F9/00 ,  G02C7/04

CPC分类号： A61F2/142 ,  A61F2/14 ,  A61F9/00 ,  A61F2250/0067 ,  G02C7/047

摘要： A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.

公开(公告)号：US20150133878A1

公开(公告)日：2015-05-14

申请号：US14600505

申请日：2015-01-20

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

IPC分类号： A61F9/00 ,  A61L27/16 ,  A61L27/02 ,  A61K9/00

CPC分类号： A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

摘要翻译： 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

公开(公告)号：US08939948B2

公开(公告)日：2015-01-27

申请号：US13618052

申请日：2012-09-14

申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton ,  Alexander J. Gould

IPC分类号： A61M35/00 ,  A61B17/00 ,  A61F9/00 ,  A61K9/00 ,  A61K47/34

CPC分类号： A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

摘要翻译： 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

公开(公告)号：US20130144128A1

公开(公告)日：2013-06-06

申请号：US13618052

申请日：2012-09-14

申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton

发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton

IPC分类号： A61B17/00

CPC分类号： A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

摘要翻译： 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

公开(公告)号：US20120136322A1

公开(公告)日：2012-05-31

申请号：US13151001

申请日：2011-06-01

申请人： Yair Alster ,  Eugene de Juan, JR. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  K. Angela Macfarlane ,  Douglas Sutton

发明人： Yair Alster ,  Eugene de Juan, JR. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  K. Angela Macfarlane ,  Douglas Sutton

IPC分类号： A61F9/00 ,  A61M35/00

CPC分类号： A61F9/0026 ,  A61F9/0017 ,  A61K9/0051 ,  A61K31/19 ,  A61K31/335 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/43 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/56 ,  A61K31/568 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7036 ,  A61K38/00 ,  A61M31/002

摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

摘要翻译： 治疗系统包括放置在眼睛的光学区域外的区域上的眼部插入物。 眼睛插入件包括两个结构：第一骨架结构和第二缓冲结构。 第一结构用作骨架框架，其保持沿着眼睛前部的植入物的定位，并向第二缓冲结构提供支撑。 该第一结构将治疗系统的附着维持在眼前部至少三十天。 在一些实施例中，第一结构保持恒定的尺寸和形状，例如。 环形，具有触觉的环或曲线环，其限制并限制性地接合下部和上结膜，以将植入物保持在泪液和/或针对眼睛的组织。

公开(公告)号：US09421126B2

公开(公告)日：2016-08-23

申请号：US13151001

申请日：2011-06-01

申请人： Yair Alster ,  Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  K. Angela Macfarlane ,  Douglas Sutton

发明人： Yair Alster ,  Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  K. Angela Macfarlane ,  Douglas Sutton

IPC分类号： A61F9/00 ,  A61M35/00 ,  A61K9/00 ,  A61K31/19 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/43 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/56 ,  A61K31/568 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7036 ,  A61K38/00 ,  A61M31/00

CPC分类号： A61F9/0026 ,  A61F9/0017 ,  A61K9/0051 ,  A61K31/19 ,  A61K31/335 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/43 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/56 ,  A61K31/568 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7036 ,  A61K38/00 ,  A61M31/002

摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

摘要翻译： 治疗系统包括放置在眼睛的光学区域外的区域上的眼部插入物。 眼睛插入件包括两个结构：第一骨架结构和第二缓冲结构。 第一结构用作骨架框架，其保持沿着眼睛前部的植入物的定位，并向第二缓冲结构提供支撑。 该第一结构将治疗系统的附着维持在眼前部至少三十天。 在一些实施例中，第一结构保持恒定的尺寸和形状，例如。 环形，具有触觉的环或曲线环，其限制并限制性地接合下部和上部结膜孔，以将植入物保持在泪液和/或针对眼睛的组织。

公开(公告)号：US20100036488A1

公开(公告)日：2010-02-11

申请号：US12384659

申请日：2009-04-06

申请人： Eugene de Juan, JR. ,  Cary J. Reich ,  Stephen Boyd ,  Yair Alster ,  David Sierra ,  Hanson S. Gifford ,  Jose D. Alejandro ,  Richard L. Lindstrom ,  K. Angela Macfariane ,  Douglas Sutton ,  John Anthony

发明人： Eugene de Juan, JR. ,  Cary J. Reich ,  Stephen Boyd ,  Yair Alster ,  David Sierra ,  Hanson S. Gifford ,  Jose D. Alejandro ,  Richard L. Lindstrom ,  K. Angela Macfariane ,  Douglas Sutton ,  John Anthony

IPC分类号： A61F2/14

CPC分类号： A61F2/142 ,  A61F2/14 ,  A61F9/00 ,  A61F2250/0067 ,  G02C7/047

摘要： A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.

摘要翻译： 用于治疗上皮缺损的治疗镜片包括设置在基质和/或Bowman膜上的治疗材料层，以抑制从泪液到基质和/或Bowman膜的水流，使得可以恢复角膜deturgescence 减少角膜肿胀和光散射。 该层可以覆盖并保护神经纤维以减轻疼痛。 该层可以包括折射率以抑制从基质和/或Bowman膜的前表面的光散射。 透镜可以包括弯曲的前表面，当上皮再生时，该前表面为患者提供功能视觉。 治疗材料层可以以许多方式定位在眼睛上，例如通过固化以将该层粘附到基质和/或Bowman膜的暴露表面上的喷雾。

公开(公告)号：US08715712B2

公开(公告)日：2014-05-06

申请号：US13688019

申请日：2012-11-28

申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Jose D. Alejandro

发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Jose D. Alejandro

IPC分类号： A61F2/00

CPC分类号： A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

摘要翻译： 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

公开(公告)号：US20130090612A1

公开(公告)日：2013-04-11

申请号：US13688019

申请日：2012-11-28

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Jose D. Alejandro

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Jose D. Alejandro

IPC分类号： A61F9/00

CPC分类号： A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

公开(公告)号：US09107773B2

公开(公告)日：2015-08-18

申请号：US13555056

申请日：2012-07-20

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F13/12 ,  A61F9/00 ,  A61F9/013 ,  A61F9/04 ,  A61L27/18 ,  G02C7/04 ,  A61F9/008

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.