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    Device and system for mixing and dispensing components stored separately from one another
    1.
    发明授权
    Device and system for mixing and dispensing components stored separately from one another 有权
    用于混合和分配彼此分开存储的部件的装置和系统

    公开(公告)号：US08596859B2

    公开(公告)日：2013-12-03

    申请号：US12734404

    申请日：2008-11-06

    申请人： Yiping Wang ,  William S. Wei ,  Daniel W. Frank

    发明人： Yiping Wang ,  William S. Wei ,  Daniel W. Frank

    IPC分类号： B01F5/08

    CPC分类号： A61J1/2093 ,  A61J1/2096 ,  A61M5/008 ,  A61M5/31505 ,  A61M5/3156 ,  A61M5/31563 ,  A61M5/31596 ,  A61M2005/3104 ,  A61M2005/31508 ,  A61M2205/6045 ,  A61M2205/6081 ,  B01F5/0685 ,  B01F5/0688 ,  B01F13/002 ,  B01F13/0023

    摘要： Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.

    摘要翻译： 公开了混合装置和系统，用于存储单独的部件并根据需要混合和分配这些部件。 混合装置包括具有形成有混合室的大致管状壳体的注射器。 柱塞装配到管状壳体以形成第一注射器。 分配注射器可释放地连接到混合室。 此时，每个注射器保持所需量的混合物组分。 一个注射器的内容物通过混合室到另一个注射器，形成通常不完全的混合物。 然后将混合物通过混合室至另一个注射器。 持续多次通过混合室，直到达到所需的混合结果，并且混合物料被包含在第二注射器中，用于此后分配所需量的混合物。

    DEVICE AND SYSTEM FOR MIXING AND DISPENSING COMPONENTS STORED SEPARATELY FROM ONE ANOTHER
    2.
    发明申请
    DEVICE AND SYSTEM FOR MIXING AND DISPENSING COMPONENTS STORED SEPARATELY FROM ONE ANOTHER 有权
    用于混合和分配组件的设备和系统与其他单独存储

    公开(公告)号：US20100260004A1

    公开(公告)日：2010-10-14

    申请号：US12734404

    申请日：2008-11-06

    申请人： Yiping Wang ,  William S. Wei ,  Daniel W. Frank

    发明人： Yiping Wang ,  William S. Wei ,  Daniel W. Frank

    IPC分类号： B01F5/20

    CPC分类号： A61J1/2093 ,  A61J1/2096 ,  A61M5/008 ,  A61M5/31505 ,  A61M5/3156 ,  A61M5/31563 ,  A61M5/31596 ,  A61M2005/3104 ,  A61M2005/31508 ,  A61M2205/6045 ,  A61M2205/6081 ,  B01F5/0685 ,  B01F5/0688 ,  B01F13/002 ,  B01F13/0023

    摘要： Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.

    摘要翻译： 公开了混合装置和系统，用于存储单独的部件并根据需要混合和分配这些部件。 混合装置包括具有形成有混合室的大致管状壳体的注射器。 柱塞装配到管状壳体以形成第一注射器。 分配注射器可释放地连接到混合室。 此时，每个注射器保持所需量的混合物组分。 一个注射器的内容物通过混合室到另一个注射器，形成通常不完全的混合物。 然后将混合物通过混合室至另一个注射器。 持续多次通过混合室，直到达到所需的混合结果，并且混合物料被包含在第二注射器中，用于此后分配所需量的混合物。

    Stabilized prostaglandin E composition
    3.
    发明授权
    Stabilized prostaglandin E composition 有权
    稳定的前列腺素E组成

    公开(公告)号：US07560489B2

    公开(公告)日：2009-07-14

    申请号：US11546196

    申请日：2006-10-11

    申请人： Daniel W. Frank ,  Yiping Wang

    发明人： Daniel W. Frank ,  Yiping Wang

    IPC分类号： A61K31/557

    CPC分类号： A61K31/19 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/36

    摘要： A prostaglandin E composition comprises are substantially free from C1-C4 alcohols and include the prostaglandin E compound together with a (C1-C4)-alkyl(C8-C22)carboxylic ester (e.g., ethyl laurate), an N,N-di(C1-C8)alkylamino substituted, (C4-C18)alkyl(C2-C18)carboxylic ester and/or a pharmaceutically acceptable addition salt thereof, and optionally, a viscosity enhancing agent such as guar gum. The prostaglandin E composition can be combined with an aqueous alcoholic diluent to form a pharmaceutical composition for topical application to a patient, for example, to treat sexual dysfunction. The prostaglandin E compositions are stable for prolonged periods of storage at room temperature.

    摘要翻译： 前列腺素E组合物基本上不含C 1 -C 4醇，并且包括前列腺素E化合物与（C 1 -C 4） - 烷基（C 8 -C 22）羧酸酯（例如月桂酸乙酯），N，N-二 C 1 -C 8）烷基氨基取代的（C 4 -C 18）烷基（C 2 -C 18）羧酸酯和/或其药学上可接受的加成盐，以及任选的粘度增强剂如瓜耳胶。 前列腺素E组合物可与含水酒精稀释剂组合以形成用于局部应用于患者的药物组合物，例如治疗性功能障碍。 前列腺素E组合物在室温下长时间储存​​是稳定的。

    Stabilized prostaglandin E composition
    4.
    发明申请
    Stabilized prostaglandin E composition 有权
    稳定的前列腺素E组成

    公开(公告)号：US20080090911A1

    公开(公告)日：2008-04-17

    申请号：US11546196

    申请日：2006-10-11

    申请人： Daniel W. Frank ,  Yiping Wang

    发明人： Daniel W. Frank ,  Yiping Wang

    IPC分类号： A61K31/557 ,  A61K9/00

    CPC分类号： A61K31/19 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/36

    摘要： A prostaglandin E composition comprises are substantially free from C1-C4 alcohols and include the prostaglandin E compound together with a (C1-C4)-alkyl (C8-C22) carboxylic ester (e.g., ethyl laurate), an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester and/or a pharmaceutically acceptable addition salt thereof, and optionally, a viscosity enhancing agent such as guar gum. The prostaglandin E composition can be combined with an aqueous alcoholic diluent to form a pharmaceutical composition for topical application to a patient, for example, to treat sexual dysfunction. The prostaglandin E compositions are stable for prolonged periods of storage at room temperature.

    摘要翻译： 前列腺素E组合物包含基本上不含C 1 -C 4醇，并且包括前列腺素E化合物以及（C 1 -C 4 - 羧酸酯（例如月桂酸乙酯），N，N-二（C 1 -C 6烷基）烷基（C 8 -C 22 - C 1 -C 8烷基氨基取代的（C 1 -C 4 -C 18）烷基（C 2 -C 8烷基） 羧酸酯和/或其药学上可接受的加成盐，以及任选的粘度增强剂如瓜耳胶。 前列腺素E组合物可与含水酒精稀释剂组合以形成用于局部应用于患者的药物组合物，例如治疗性功能障碍。 前列腺素E组合物在室温下长时间储存​​是稳定的。

    METHODS AND COMPOSITIONS FOR TREATING RAYNAUD'S DISEASE
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING RAYNAUD'S DISEASE 有权
    治疗RAYNAUD疾病的方法和组合

    公开(公告)号：US20140200274A1

    公开(公告)日：2014-07-17

    申请号：US14110348

    申请日：2012-04-06

    申请人： Daniel W. Frank ,  Richard Martin ,  Bassam B. Damaj

    发明人： Daniel W. Frank ,  Richard Martin ,  Bassam B. Damaj

    IPC分类号： A61K31/201

    CPC分类号： A61K31/191 ,  A61J1/05 ,  A61K9/0014 ,  A61K31/201 ,  A61K31/5575 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/36

    摘要： In various embodiments, methods and compositions for treating Raynaud's disease and Raynaud's phenomenon are provided. Topical administration of a semisolid composition comprising a prostaglandin E1 compound provides the desired relief of the Raynaud's disease or Raynaud's phenomenon without the possible complications of systemic administration. The semisolid composition can be administered as needed, or in a regimen of several doses per day.

    摘要翻译： 在各种实施方案中，提供了用于治疗雷诺氏病和雷诺现象的方法和组合物。 包含前列腺素E1化合物的半固体组合物的局部施用提供了雷诺氏病或雷诺现象的所需缓解，而没有全身给药的可能并发症。 半固体组合物可以根据需要或以每天几剂量的方案给药。