摘要:
The present invention provides a novel transmembrane protein, which is a nuclear factor of activated T cells (“NEAT”) receptor, and related compositions and methods.
摘要:
The present invention provides a novel transmembrane protein, which is a nuclear factor of activated T cells (‘NFAT’) receptor, and related compositions and methods.
摘要:
Novel nuclear factor of activated T cells (“NFAT”) activating receptor useful for producing agonist and antagonist antibodies that regulate the cellular production and expression of cytokines and cellular receptors. The receptor is a 270 amino acid type I transmembrane protein with a calculated molecular mass of about 30 kD. The receptor has a putative signal peptide at the N-terminal (amino acids 1-42), an Ig-domain (amino acids 43-150) in the extracellular region, a predicted transmembrane domain (amino acids 164-186), and an predicted ITAM motif (amino acids 220-235) in the cytoplasmic region. The receptor activates NFAT, IL-13 and TNF alpha promoter reporter activities.
摘要:
The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
摘要:
The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
摘要:
The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
摘要:
The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
摘要:
Motifs and patterns are generated by computer and printed on fabric, paper or plastic materials in continuous non-repeating patterns. The data is produced automatically by a random math algorithm, so that each of the printed patterns is similar, but not identical. The layout is arranged in a random manner, so that every part of the print is unique and exclusive. The size, color, motifs as well as the level of similarity or variety of the motifs and any other parameter essential to the design are all managed by the software.
摘要:
A promoter comprising the isolated promoter region of the human Thymic Stromal Lymphopoietin (TSLP) gene and functional portions of the promoter region having TSLP promoter activity. The promoters are useful for identifying promoter agonists and antagonists that can be used to prevent or treat allergic conditions and autoimmune diseases.
摘要:
Mast cell-expressed membrane proteins that are highly expressed in human mast cells and the lungs as compared to brain, heart, kidney, liver, tracheal, and similar tissues. The proteins are transmembrane proteins involved in the regulation of mast cell and lung tissue function, including degranulation of mast cells. The preferred protein is a 187 amino acid transmembrane protein having an intercellular domain comprising amino acids 1 through 82, a transmembrane domain comprising amino acids 83 through 105, and an extracellular domain comprising amino acids 106 through 187 (SEQ ID NO:2).
摘要翻译:与大脑,心脏,肾脏,肝脏,气管和类似组织相比,肥大细胞表达的膜蛋白在人类肥大细胞和肺中高度表达。 蛋白质是涉及肥大细胞和肺组织功能调节的跨膜蛋白,包括肥大细胞的脱颗粒。 优选的蛋白质是187氨基酸跨膜蛋白,其具有包含氨基酸1至82的细胞间结构域,包含氨基酸83至105的跨膜结构域和包含氨基酸106至187(SEQ ID NO:2)的细胞外结构域。