Nuclear factor of activated t cell receptor
    3.
    发明申请
    Nuclear factor of activated t cell receptor 审中-公开
    活化的T细胞受体的核因子

    公开(公告)号:US20060292668A1

    公开(公告)日:2006-12-28

    申请号:US10528326

    申请日:2003-09-19

    CPC分类号: C07K14/4702 A61K38/00

    摘要: Novel nuclear factor of activated T cells (“NFAT”) activating receptor useful for producing agonist and antagonist antibodies that regulate the cellular production and expression of cytokines and cellular receptors. The receptor is a 270 amino acid type I transmembrane protein with a calculated molecular mass of about 30 kD. The receptor has a putative signal peptide at the N-terminal (amino acids 1-42), an Ig-domain (amino acids 43-150) in the extracellular region, a predicted transmembrane domain (amino acids 164-186), and an predicted ITAM motif (amino acids 220-235) in the cytoplasmic region. The receptor activates NFAT, IL-13 and TNF alpha promoter reporter activities.

    摘要翻译: 活化的T细胞(“NFAT”)激活受体的新核因子可用于产生调节细胞因子和细胞受体的细胞产生和表达的激动剂和拮抗剂抗体。 该受体是270个氨基酸的I型跨膜蛋白,其计算分子量约为30kD。 受体在N-末端(氨基酸1-42),细胞外区域中的Ig结构域(氨基酸43-150),预测的跨膜结构域(氨基酸164-186)和 在细胞质区域预测ITAM基序(氨基酸220-235)。 受体激活NFAT,IL-13和TNFα启动子记录活性。

    Anti-Notch3 antibodies
    4.
    发明授权
    Anti-Notch3 antibodies 有权
    抗Notch3抗体

    公开(公告)号:US08513388B2

    公开(公告)日:2013-08-20

    申请号:US13174285

    申请日:2011-06-30

    摘要: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.

    摘要翻译: 本发明涉及与人Notch3特异性结合的新型抗体及其在检测和/或诊断Notch3相关疾病如癌症中的用途。 本发明还包括编码这些新型抗体的核酸,携带核酸的载体和细胞系,以及包含用于检测和诊断的抗体的试剂盒。

    Human mast cell-expressed membrane protein (gpcr)
    8.
    发明申请
    Human mast cell-expressed membrane protein (gpcr) 审中-公开
    人肥大细胞表达膜蛋白(gpcr)

    公开(公告)号:US20070260042A1

    公开(公告)日:2007-11-08

    申请号:US10562233

    申请日:2004-01-26

    IPC分类号: C07K14/00

    CPC分类号: B41J3/4078

    摘要: Motifs and patterns are generated by computer and printed on fabric, paper or plastic materials in continuous non-repeating patterns. The data is produced automatically by a random math algorithm, so that each of the printed patterns is similar, but not identical. The layout is arranged in a random manner, so that every part of the print is unique and exclusive. The size, color, motifs as well as the level of similarity or variety of the motifs and any other parameter essential to the design are all managed by the software.

    摘要翻译: 主题和图案由计算机生成,并以连续的非重复图案印在织物,纸张或塑料材料上。 数据通过随机数学算法自动产生,使得每个打印图案相似但不相同。 布局以随机的方式布置,使得打印的每个部分都是独一无二的。 尺寸,颜色,图案以及图案的相似性或多样性水平以及设计所必需的任何其他参数均由软件管理。