公开(公告)号：US09855217B2

公开(公告)日：2018-01-02

申请号：US15023110

申请日：2014-09-18

Applicant: STC.UNM ,  National Technology & Engineering Solutions of Sandia, LLC

Inventor： C. Jeffrey Brinker ,  Yu-Shen Lin

IPC: A61K9/14 ,  A61K9/127 ,  A61K31/7088 ,  B82Y5/00 ,  A61K9/51 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  C12N15/88 ,  B82Y15/00

CPC classification number: A61K9/1271 ,  A61K9/14 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/88

Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

公开(公告)号：US09823486B2

公开(公告)日：2017-11-21

申请号：US15133054

申请日：2016-04-19

Applicant: STC. UNM

Inventor： Sudhakar Prasad

IPC: G02B27/58 ,  G01C11/02 ,  G02B5/30 ,  G02B5/18 ,  G02B21/36 ,  G02B27/26 ,  G02B27/00

CPC classification number: G02B27/58 ,  G01B11/002 ,  G01C11/02 ,  G02B5/189 ,  G02B5/3083 ,  G02B21/36 ,  G02B21/361 ,  G02B27/0075 ,  G02B27/26

Abstract: An optical imaging system having an aperture comprised of a plurality of concentric annuli. The outer radius of each annulus is proportional to the square root of the number of annuli. Each annulus also having an azimuthally linearly increasing phase profile comprising for a given light wavelength. The system also includes a birefringent plate and the aperture and birefringent plate are adapted to jointly encode the full spatial and polarimetric degrees of freedom of a point source.

公开(公告)号：US20150293004A1

公开(公告)日：2015-10-15

申请号：US14545590

申请日：2015-05-27

Applicant: STC. UNM ,  Senior Scientific, LLC

Inventor： Natalie L. Adolphi ,  Edward R. Flynn ,  Howard Bryant ,  Kimberly Butler

IPC: G01N11/12

CPC classification number: G01N11/12 ,  B82Y15/00 ,  G01N2011/0086

Abstract: A method for measuring the average viscosity of a test fluid uses calibrated magnetic nanoparticles, with certain chosen hydrodynamic diameters and actual lateral dimensions (e.g. diameters), that are mixed into a small volume of the test fluid and a single magnetic relaxation curve measurement to provide data for viscosity determination. The distribution of hydrodynamic particle sizes of an ensemble of magnetic nanoparticles that are magnetically blocked at room temperature can be determined. Modifications of the method can be used to determine the distribution of viscosities in a complex fluid at the sub-microscopic level providing a novel type of viscosity measurement.

Abstract translation: 用于测量测试流体的平均粘度的方法使用校准的磁性纳米颗粒，其具有某些选定的流体动力学直径和实际横向尺寸（例如直径），其被混合到小体积的测试流体中，并且提供单个磁弛张曲线测量值以提供 粘度测定数据。 可以确定在室温下磁性阻断的磁性纳米颗粒组的流体动力学粒径的分布。 该方法的修改可以用于确定在亚微观水平的复杂流体中的粘度分布，提供新型粘度测量。

公开(公告)号：US08880141B2

公开(公告)日：2014-11-04

申请号：US12995313

申请日：2009-06-01

Applicant: Jingkuang Chen

Inventor： Jingkuang Chen

IPC: G01N29/00 ,  A61B8/00 ,  A61B5/00 ,  G01N29/24

CPC classification number: A61B5/0095 ,  A61B5/0048 ,  A61B5/0091 ,  A61B5/0093 ,  A61B5/4312 ,  A61B8/44 ,  A61B8/4444 ,  A61B8/4483 ,  A61B8/483 ,  A61B2562/02 ,  A61B2562/028 ,  G01N21/1702 ,  G01N29/24 ,  G01N29/2406 ,  G01N29/2418 ,  G01N2021/1706 ,  G01N2291/02475 ,  G01N2291/106

Abstract: A photoacoustic imaging device includes an array of light sources configured and arranged to illuminate a target region and an array of ultrasonic transducers between the array of light sources and the target region. The array of transducers may be fixedly coupled to the array of light sources, and the array of ultrasonic transducers may be configured and arranged to receive ultrasound transmissions from the target region.

Abstract translation: 光声成像装置包括配置和布置成在光源阵列和目标区域之间照射目标区域和超声波换能器阵列的光源阵列。 换能器阵列可以固定地耦合到光源阵列，并且超声换能器阵列可以被配置和布置成从目标区域接收超声波传输。

公开(公告)号：US08648167B1

公开(公告)日：2014-02-11

申请号：US13439661

申请日：2012-04-04

Applicant: Elizabeth L Hedberg-Dirk ,  Shawn Dirk ,  Kirsten Cicotte

Inventor： Elizabeth L Hedberg-Dirk ,  Shawn Dirk ,  Kirsten Cicotte

IPC: C08G63/52

CPC classification number: C08G63/52 ,  C08F222/10

Abstract: A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.

Abstract translation: 描述适合用作生物相容性构建体的多种聚合物和共聚物，以及作为非限制性具体实例的可降解组织支架的形成以及用于合成这些聚合物和共聚物的方法。 聚合物和共聚物的降解速率明显快于适用于相同用途的前述聚合物的降解速率。 还描述了具有能够通过选择所得共聚物中单体的特定化学计量来微调降解速率的合成途径的共聚物。 本公开还提供了一种用于马来酰氯的新型合成路线，其产生适用于本文所述共聚物合成方法的单体。

公开(公告)号：US20120207913A1

公开(公告)日：2012-08-16

申请号：US13389558

申请日：2010-08-27

Applicant: Hugh D.C. Smyth ,  Martin J. Donovan

Inventor： Hugh D.C. Smyth ,  Martin J. Donovan

IPC: B05D7/24 ,  B05C11/00 ,  B05C19/04

CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.

Abstract translation: 将粉末状药剂涂布在用于干粉吸入器的载体颗粒上的方法的方法可以包括将超声能量施加到附聚的粉末状药剂以将药剂的颗粒分解和雾化成具有所需平均粒径的颗粒，以及涂覆 至少一个具有所需量的药物剂的解聚集和雾化颗粒的载体颗粒。

公开(公告)号：US20110160513A1

公开(公告)日：2011-06-30

申请号：US12990338

申请日：2009-05-04

Applicant: Shuan Luan ,  Nathan Swanson ,  Lijun Ma

Inventor： Shuan Luan ,  Nathan Swanson ,  Lijun Ma

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61B34/10 ,  A61B90/10 ,  A61B2090/101 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1084

Abstract: The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of “dose-painting” to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical “paintbrush”, and treatment planning is reduced to finding the best route of this “paintbrush” to “paint” a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

Abstract translation: 本发明是基于“剂量绘画”的概念，利用伽玛刀C和Perfexion单元上的机器人患者定位系统开发伽玛刀放射外科手术的动态方案和系统。 由伽玛刀单元创建的球形高剂量体积将被视为3D球形“画笔”，并且减少治疗计划以找到该“画笔”最佳路线来“绘制”3D肿瘤体积。 在剂量绘画概念下，伽玛刀放射外科手术变得动态，病人在机器人定位系统下连续移动。

公开(公告)号：US20110033380A1

公开(公告)日：2011-02-10

申请号：US12811946

申请日：2009-01-12

Applicant: Yubin Mlao ,  Haixun Guo

Inventor： Yubin Mlao ,  Haixun Guo

IPC: A61K51/08 ,  C07K7/52

CPC classification number: A61K51/088 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K45/06 ,  C07K14/685 ,  G01N33/5743 ,  G01N33/60

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及包含环肽的新型非侵入性诊断工具/化合物，其中所述化合物结合MSH受体以在体内成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。 本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US07879304B1

公开(公告)日：2011-02-01

申请号：US12015412

申请日：2008-01-16

Applicant: Timothy L Ward ,  Jaime Bravo ,  Abhaya Datye ,  Gabriel Lopez ,  Hien Pham ,  Shailendra Rathod ,  Venkata Goparaju

Inventor： Timothy L Ward ,  Jaime Bravo ,  Abhaya Datye ,  Gabriel Lopez ,  Hien Pham ,  Shailendra Rathod ,  Venkata Goparaju

IPC: C01B33/12

CPC classification number: A61K9/1272 ,  A61K9/1617

Abstract: The present invention provides for evaporation induced self-assembly (EISA) within microdroplets produced by a vibrating orifice aerosol generator (VOAG) for the production of monodisperse mesoporous silica particles. The process of the present invention exploits the concentration of evaporating droplets to induce the organization of various amphiphilic molecules, effectively partitioning a silica precursor to the hydrophilic regions of the structure. Promotion of silica condensation, followed by removal of the surfactant, provides ordered spherical mesoporous particles.

Abstract translation: 本发明提供由用于生产单分散介孔二氧化硅颗粒的振动孔气溶胶发生器（VOAG）产生的微滴内的蒸发诱导自组装（EISA）。 本发明的方法利用蒸发液滴的浓度来诱导各种两亲分子的组织，有效地将二氧化硅前体分配到结构的亲水区域。 促进二氧化硅凝结，然后除去表面活性剂，提供有序的球形中孔颗粒。

公开(公告)号：US07670988B2

公开(公告)日：2010-03-02

申请号：US11873568

申请日：2007-10-17

Applicant: Elise Switzer ,  Plamen Atanassov ,  Abhaya Datye

Inventor： Elise Switzer ,  Plamen Atanassov ,  Abhaya Datye

IPC: B01J23/42 ,  B01J23/46 ,  B01J23/62

CPC classification number: H01M4/921

Abstract: An aerosol-assisted method for synthesis of nanostructured metallic electrocatalysts and the electrocatalysts formed thereby. The electrocatalyst may be formed from metals such as, but not limited to, platinum, platinum group metals, and binary and tertiary compositions thereof such as, for example, platinum-ruthenium and platinum-tin. The resulting unsupported electrocatalyst is homogenous and highly disperse.

Abstract translation: 用于合成纳米结构金属电催化剂的气溶胶辅助方法和由此形成的电催化剂。 电催化剂可以由金属形成，例如但不限于铂，铂族金属及其二元和三级组合物，例如铂 - 钌和铂 - 锡。 所得的无载体电催化剂是均匀的并且高度分散。