公开(公告)号：US20110218431A1

公开(公告)日：2011-09-08

申请号：US13015878

申请日：2011-01-28

申请人： Manfred Fink ,  Philip Varghese ,  Jacek Borysow

发明人： Manfred Fink ,  Philip Varghese ,  Jacek Borysow

IPC分类号： A61B6/00 ,  G01J3/44

CPC分类号： G01J3/44 ,  A61B5/0075 ,  A61B5/0836 ,  A61B5/7257 ,  G01J3/02 ,  G01J3/0227 ,  G01J3/0232 ,  G01N21/65

摘要： A Raman analyzer for analyzing light emitted from a Raman cell is provided that has a beam splitter configured to split the light emitted from the Raman cell into a first beam and a second beam. An atomic vapor filter can be used to filter a Raman scattered line from the first beam and a chopper system can periodically interrupt the first and second beams that are directed towards a photo detector, which can convert light from the first and second beams into an electrical signal. The signal output from the photo detector can optionally be amplified, digitized, Fourier filtered, and/or subjected to Fourier analysis.

摘要翻译： 提供了用于分析从拉曼单元发射的光的拉曼分析器，其具有分束器，其被配置为将从拉曼单元发射的光分成第一光束和第二光束。 可以使用原子蒸汽过滤器来从第一光束过滤拉曼散射线，并且斩波系统可以周期性地中断指向光电检测器的第一和第二光束，其可以将来自第一和第二光束的光转换成电 信号。 从光电检测器输出的信号可以可选地被放大，数字化，傅里叶滤波和/或进行傅立叶分析。

公开(公告)号：US5466676A

公开(公告)日：1995-11-14

申请号：US823783

申请日：1992-01-23

申请人： Frank W. Booth ,  Donald B. Thomason ,  Paul R. Morrison ,  George M. Stancel

发明人： Frank W. Booth ,  Donald B. Thomason ,  Paul R. Morrison ,  George M. Stancel

IPC分类号： A61K48/00 ,  C12N5/077 ,  C12N15/867 ,  C12N15/00

CPC分类号： C12N15/86 ,  C12N5/0658 ,  A61K48/00 ,  C12N2740/13043

摘要： Novel methods of retroviral-mediated gene transfer for the in vivo corporation and stable expression of eukaryotic or prokaryotic foreign genes in tissues of living animals is described. More specifically, methods of incorporating foreign genes into mitotically active cells are disclosed. The constitutive and stable expression of E. coli .beta.-galactosidase gene under the promoter control of the Moloney murine leukemia virus long terminal repeat is employed as a particularly preferred embodiment, by way of example, establishes the model upon which the incorporation of a foreign gene into a mitotically-active living eukaryotic tissue is based.Use of the described methods in therapeutic treatments for genetic diseases, such as those muscular degenerative diseases, is also presented. In muscle tissue, the described processes result in genetically-altered satellite cells which proliferate daughter myoblasts which preferentially fuse to form a single undamaged muscle fiber replacing damaged muscle tissue in a treated animal. The retroviral vector, by way of example, includes a dystrophin gene construct for use in treating muscular dystrophy.The present invention also comprises an experimental model utilizable in the study of the physiological regulation of skeletal muscle gene expression in intact animals.

摘要翻译： 描述了用于体内公司的逆转录病毒介导的基因转移的新方法，并且描述了活体组织中真核或原核外来基因的稳定表达。 更具体地，公开了将外来基因并入有丝分裂活性细胞中的方法。 采用莫洛尼鼠白血病病毒长末端重复启动子控制下的大肠杆菌β-半乳糖苷酶基因的组成型和稳定表达作为特别优选的实施方案，通过实例建立了外源基因掺入的模型 以有丝分裂活性的生物真核组织为基础。 还介绍了所述方法在诸如那些肌肉退行性疾病等遗传疾病的治疗方法中的应用。 在肌肉组织中，所描述的过程导致遗传改变的卫星细胞，其增殖子母细胞，其优先融合以形成单个未损伤肌肉纤维，以替代处理的动物中的损伤的肌肉组织。 作为示例，逆转录病毒载体包括用于治疗肌营养不良症的肌营养不良蛋白基因构建体。 本发明还包括可用于研究完整动物中骨骼肌基因表达的生理调节的实验模型。

公开(公告)号：US11581402B2

公开(公告)日：2023-02-14

申请号：US17273634

申请日：2019-09-05

申请人： The University of Texas at Austin

发明人： Qin Huang

IPC分类号： H01L29/40 ,  H01L29/872 ,  H01L29/06 ,  H01L29/16 ,  H01L29/78

摘要： A method and apparatus include an n-doped layer having a first applied charge, and a p−-doped layer having a second applied charge. The p−-doped layer may be positioned below the n-doped layer. A p+-doped buffer layer may have a third applied charge and be positioned below the p−-doped layer. The respective charges at each layer may be determined based on a dopant level and a physical dimension of the layer. In one example, the n-doped layer, the p−-doped layer, and the p+-doped buffer layer comprise a lateral semiconductor manufactured from silicon carbide (SiC).

公开(公告)号：US20210344275A1

公开(公告)日：2021-11-04

申请号：US17273655

申请日：2019-09-05

申请人： The University of Texas at Austin

发明人： Qin HUANG

IPC分类号： H02M5/257 ,  H02J3/18 ,  H02M3/335 ,  H02M5/14 ,  H02M1/00

摘要： A method and apparatus include a primary transformer coil, a secondary transformer coil, and a center tapped inductor coupled to the secondary transformer coil. A first switch may be in electrical communication with the center tapped inductor and may be configured to affect the first output voltage. A second switch may be in electrical communication with the center tapped inductor and may be configured to affect the second output voltage. In a particular example with an analog current (AC) output voltage, the two output voltages are out of phase to each other. In a direct current (DC) implementation, the transformer may be operated to output a positive and a negative output voltage. The apparatus may function as a resonant converter, or may operate in non-resonant mode. In one implementation, an H bridge may provide reactive power support. An inductor filter may be in electrical communication with the secondary transformer coil. Where desired, a diode bridge may be in electrical communication with the primary transformer coil.

公开(公告)号：US20210242776A1

公开(公告)日：2021-08-05

申请号：US17049286

申请日：2019-05-08

申请人： The University of Texas at Austin

发明人： Alex HUANG ,  Qingyun HUANG

IPC分类号： H02M3/158 ,  H02M1/00 ,  H02M1/08

摘要： Method and apparatus include a circuit having a duty cycle and interleaving modulation configured to realize high density and efficient energy transfer. The circuit may efficiently achieve higher step-down voltage ratios with fewer electrical components. For example, as few as seven electrical devices, such as switches and diodes, may be used to realize at least a four-to-one conversion ratio. The high density of the circuit is advantageous to meet shrinking space demands. A modulator may interleave signals sent to the electrical components (e.g., switching devices via driver circuitry). The driver signals may include a duty cycle of 1/(nc+1), where nc is (n−1)/3, and n is the number of devices.

公开(公告)号：US20080124767A1

公开(公告)日：2008-05-29

申请号：US11866879

申请日：2007-10-03

申请人： David R. Nobles ,  R. Malcolm Brown

发明人： David R. Nobles ,  R. Malcolm Brown

IPC分类号： C12P19/44 ,  C12N1/12

CPC分类号： C12P19/12

摘要： The present invention includes compositions and methods for making and producing sucrose from cyanobacteria, by growing a cyanobacterium in a growth medium; incubating the cyanobacteria in a salt containing medium under conditions that promote sucrose production; and exposing the cyanobacteria to acidic conditions, wherein the acidic conditions trigger sucrose secretion into the medium. The compositions and methods of the present invention may be used as a new global crop for the manufacture of sucrose, glucose, or fructose, CO2 fixation, for the production of alternative sources of conventional cellulose as well as a biofuel and precursors thereof.

摘要翻译： 本发明包括通过在生长培养基中生长蓝细菌来从蓝细菌制备和生产蔗糖的组合物和方法; 在促进蔗糖生产的条件下将含氮培养基中的蓝细菌培养; 并将蓝藻暴露于酸性条件，其中酸性条件引发蔗糖分泌到培养基中。 本发明的组合物和方法可用作制备蔗糖，葡萄糖或果糖CO 2 2固定物的新的全球作物，用于生产常规纤维素的替代来源以及 生物燃料及其前体。

公开(公告)号：US20210355195A1

公开(公告)日：2021-11-18

申请号：US17308753

申请日：2021-05-05

申请人： Albert Einstein College of Medicine ,  Adimab, LLC ,  Mapp Biopharmaceutical, Inc. ,  The University of Texas at Austin

发明人： Zachary A. Bornholdt ,  Akaash Mishra ,  Laura M. Walker ,  Noel T. Pauli ,  Daniel Maurer ,  Kartik Chandran ,  Jens Maximilian Fels ,  Dafna Abelson ,  Jason Scott McLellan ,  Jonathan R. Lai ,  Ariel Wirchnianski ,  Olivia Vergnolle

IPC分类号： C07K16/10 ,  A61K45/06 ,  A61K39/42

摘要： Anti-CCHFV antibodies with neutralizing potency and protective efficacy against CCHFV are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.

公开(公告)号：US20130096422A1

公开(公告)日：2013-04-18

申请号：US13579113

申请日：2011-02-15

申请人： Emad Boctor ,  Jin Kang ,  Stanislav Emelianov ,  Andrei Karpiouk

发明人： Emad Boctor ,  Jin Kang ,  Stanislav Emelianov ,  Andrei Karpiouk

IPC分类号： A61B5/00 ,  A61B18/20 ,  A61B18/00 ,  A61N5/10 ,  A61B10/02

CPC分类号： A61B5/0095 ,  A61B5/4331 ,  A61B5/4381 ,  A61B5/6848 ,  A61B5/6852 ,  A61B5/7225 ,  A61B8/08 ,  A61B8/0841 ,  A61B10/0233 ,  A61B18/00 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/20 ,  A61B18/24 ,  A61B90/11 ,  A61B2017/4225 ,  A61B2018/2005 ,  A61B2090/378 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/1027 ,  A61N2005/1058

摘要： An interventional photoacoustic imaging system and method for cancer treatment comprises an optical source for applying laser energy to optically excite a treatment area, a needle, ablation tool or catheter for inserting the optical source into a body of a patient adjacent the treatment area, and an ultrasonic transducer for detecting the acoustic waves. A processor receives the raw data from the ultrasound system and processes it to thereby form a photoacoustic image of the tissue in real time. As such, image formation may be performed preoperatively, intraoperatively, and postoperatively.

摘要翻译： 用于癌症治疗的介入性光声成像系统和方法包括用于施加激光能量以光学激发治疗区域的光源，用于将光源插入邻近治疗区域的患者体内的针，消融工具或导管，以及 用于检测声波的超声换能器。 处理器从超声系统接收原始数据并对其进行处理，从而实时地形成组织的光声像。 因此，可以在术前，术中和术后进行图像形成。

公开(公告)号：US6144639A

公开(公告)日：2000-11-07

申请号：US922457

申请日：1997-09-03

申请人： Yongdong Zhao ,  San-Qi Li ,  Sam Sigarto

发明人： Yongdong Zhao ,  San-Qi Li ,  Sam Sigarto

IPC分类号： H04L12/56 ,  G08C15/00

CPC分类号： H04L12/5602 ,  H04L2012/5635

摘要： An adjustable bit rate (ABR) feedback control scheme is provided where the effects of multiloop delays and high priority traffic transmission are built into the control model. The data traffic is filtered by a low pass filter. Then, the low frequency bandwidth of the filtered traffic is measured and compared to a predetermined threshold. If the measured value exceeds the threshold, the ABR traffic flow is reduced. If the measured value is less than the threshold, the ABR traffic flow is increased. In addition, a General Prediction Control (GPC) method may be applied to the control model for optimal performance. An object of the invention is to minimize the unused link capacity subject to no congestion, where the ABR traffic is adapted to the low frequency variation of high priority traffic flow for high efficiency.

摘要翻译： 提供了一种可调节比特率（ABR）反馈控制方案，其中多循环延迟和高优先级流量传输的影响内置在控制模型中。 数据流量由低通滤波器滤波。 然后，测量滤波业务的低频带宽并与预定阈值进行比较。 如果测量值超过阈值，ABR流量就会减少。 如果测量值小于阈值，则ABR业务流量增加。 此外，通用预测控制（GPC）方法可以应用于控制模型以获得最佳性能。 本发明的一个目的是最大限度地减少没有拥塞的未使用的链路容量，其中ABR业务适用于高效率的高优先级业务流的低频变化。

公开(公告)号：US20210343836A1

公开(公告)日：2021-11-04

申请号：US17273634

申请日：2019-09-05

申请人： The University of Texas at Austin

发明人： Qin HUANG

IPC分类号： H01L29/06 ,  H01L29/16 ,  H01L29/872 ,  H01L29/40 ,  H01L29/78

摘要： A method and apparatus include an n-doped layer having a first applied charge, and a p−-doped layer having a second applied charge. The p−-doped layer may be positioned below the n-doped layer. A p+-doped buffer layer may have a third applied charge and be positioned below the p−-doped layer. The respective charges at each layer may be determined based on a dopant level and a physical dimension of the layer. In one example, the n-doped layer, the p−-doped layer, and the p+-doped buffer layer comprise a lateral semiconductor manufactured from silicon carbide (SiC).