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    Method for manufacturing neuraminic acid derivatives
    1.
    发明授权
    Method for manufacturing neuraminic acid derivatives 有权
    神经氨酸衍生物的制备方法

    公开(公告)号：US09309214B2

    公开(公告)日：2016-04-12

    申请号：US14848648

    申请日：2015-09-09

    Applicant: DAIICHI SANKYO COMPANY, LIMITED

    Inventor： Masayuki Murakami ,  Masakazu Wakayama

    IPC: C07D309/28

    CPC classification number: C07D309/28 ,  A61K31/351 ,  C07C41/60 ,  C07D231/14 ,  C07D407/06 ,  C07D498/04 ,  C07C43/32

    Abstract: A method for manufacturing a compound represented by the following formula (13): wherein R2 represents a C1-C4 alkyl group and Ac represents an acetyl group, comprising: reacting a compound represented by the following formula (12): wherein R2 represents a C1-C4 alkyl group, Ac represents an acetyl group and Boc represents a tert-butoxycarbonyl group, with water.

    Abstract translation: 一种制备由下式（13）表示的化合物的方法：其中R2表示C1-C4烷基，Ac表示乙酰基，其包括：使下式（12）表示的化合物：其中R2表示C1 -C4烷基，Ac表示乙酰基，Boc表示叔丁氧基羰基。

    Preparation of 2-chloro-1,1,1-trialkoxyethane
    3.
    发明授权
    Preparation of 2-chloro-1,1,1-trialkoxyethane 失效
    制备2-氯-1,1,1-三烷氧基乙烷

    公开(公告)号：US06747176B2

    公开(公告)日：2004-06-08

    申请号：US10457570

    申请日：2003-06-10

    Applicant: Guenther Koehler ,  Karl-Heinz Bruehl ,  Johannes Ruwwe ,  Manfred Neumann

    Inventor： Guenther Koehler ,  Karl-Heinz Bruehl ,  Johannes Ruwwe ,  Manfred Neumann

    IPC: C07C4330

    CPC classification number: C07C41/60 ,  C07C43/32

    Abstract: 2-Chloro-1,1,1-trialkoxyethane of formula (II): wherein R1 to R3, which may be the same or different, are alkyl, or any two of the alkyl groups taken together form a cyclic group, is prepared by reacting 1,1,1-trialkoxyethane with gaseous or liquid chlorine in the presence of alcohol solvent in an amount ranging from 0.1% to 20 wt %, based on the amount of 1,1,1-trialkoxyethane reactant.

    Abstract translation: 式（II）的2-氯-1,1,1-三烷氧基乙烷：其中R 1至R 3可以相同或不同，为烷基，或任意两个烷基一起形成 基于1,1,1-三烷氧基乙烷反应物的量，在醇溶剂存在下，使1,1,1-三烷氧基乙烷与气态或液态氯反应，其量为0.1〜20重量％ 。

    Method of preparing orthoacetic acid alkyl esters
    8.
    发明授权
    Method of preparing orthoacetic acid alkyl esters 失效
    正乙酸烷基酯的制备方法

    公开(公告)号：US4182910A

    公开(公告)日：1980-01-08

    申请号：US840186

    申请日：1977-10-06

    Applicant: Hans-Georg Schmidt ,  Gerhard Daum ,  Wilhelm Vogt

    Inventor： Hans-Georg Schmidt ,  Gerhard Daum ,  Wilhelm Vogt

    IPC: B01J31/00 ,  C07B61/00 ,  C07C41/00 ,  C07C41/60 ,  C07C43/32 ,  C07C67/00

    CPC classification number: C07C41/60

    Abstract: An improvement in the process for preparing an orthoacetic acid alkyl ester of the formula ##STR1## wherein R is a saturated, branched or un-branched, alkyl moiety of 1 to 8 carbon atoms by:(a) contacting acetonitrile with an anhydrous alkanol having 1 to 8 carbon atoms and dry hydrogen chloride in the presence of an organic solvent to prepare the corresponding imidoester hydrochloride;(b) thereafter contacting said imidoester hydrochloride in the acid-free state with an alkanol having 1 to 8 carbon atoms; and(c) removing by-product ammonium chloride from the resultant reaction mixture and distilling the reaction mixture to recover orthoacetic acid alkyl ester, the improvement residing in(d) employing as the organic solvent an inert solvent having a dielectric constant measured at 25.degree. C. of 2.6 or less; and(e) contacting said imidoester hydrochloride in step (b) with an alkali metal or alkaline earth metal alcoholate before contacting the same with said alkanol.Also disclosed is a process in which steps (a) and (b) are performed coterminously without isolation or recovery of the intermediate imidoester hydrochloride.

    Abstract translation: 制备式“IMAGE”的正乙酸烷基酯的方法的改进，其中R是1至8个碳原子的饱和，支化或未支化的烷基部分，通过：（a）使乙腈与具有 1至8个碳原子和干氯化氢，在有机溶剂存在下制备相应的酰亚胺盐酸盐; （b）然后将无酸状态的所述酰亚胺酯盐酸盐与具有1至8个碳原子的链烷醇接触; 和（c）从所得反应混合物中除去副产物氯化铵并蒸馏反应混合物以回收正乙酸烷基酯，改进在（d）使用在25℃下测量的介电常数的惰性溶剂作为有机溶剂 2.6以下; 和（e）使步骤（b）中的所述酰亚胺酯盐酸盐与碱金属或碱土金属醇化物接触，然后使其与所述链烷醇接触。 还公开了步骤（a）和（b）在不分离或回收中间体酰亚胺盐酸盐的情况下共同进行的方法。

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