公开(公告)号：US06844464B2

公开(公告)日：2005-01-18

申请号：US10388302

申请日：2003-03-13

Applicant: Ryoji Sugise ,  Shuji Tanaka ,  Hirofumi Ii ,  Kazuaki Mii

Inventor： Ryoji Sugise ,  Shuji Tanaka ,  Hirofumi Ii ,  Kazuaki Mii

IPC: C07C201/04 ,  C07C203/00 ,  C07C203/02

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: An alkyl nitrite is produced with high efficiency by bringing a nitrogen monoxide gas into contact with an aqueous solution of an alkyl alcohol and nitric acid in a reactor 2, which aqueous solution may be a liquid fraction generated in an alkyl nitrite-production process in which an alkyl alcohol is reacted with nitrogen monoxide and oxygen in a reaction column 1.

公开(公告)号：US3792077A

公开(公告)日：1974-02-12

申请号：US3792077D

申请日：1971-10-04

Applicant: BASF AG

Inventor： BERMES R ,  SCHMEIDL K

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/04 ,  C07C203/00 ,  C09B41/00 ,  C09B67/24 ,  C07C77/02

CPC classification number: C09B41/00 ,  C07C203/00 ,  C09B67/0072

Abstract: NITRITES OF GLYCOLS AND GLYCOL DERIVATIVES OBTAINABLE BY ESTERIFICATION WITH NITROUS ACID. THE COMPOUNDS ARE EMINENTLY SUITABLE AS DIAZOTIZING AGENTS, PARTICULARLY IN ORGANIC SOLUTION.

公开(公告)号：US3649665A

公开(公告)日：1972-03-14

申请号：US3649665D

申请日：1969-04-23

Applicant: TEXACO INC

Inventor： CHAFETZ HARRY ,  BLACKLEY WILLIAM D ,  KREUZ KENNETH L

IPC: C07C45/33 ,  C07C45/36 ,  C07C51/31 ,  C07C201/02 ,  C07C201/04 ,  C07C203/00 ,  C07C205/02 ,  C07C205/06 ,  C07C77/00 ,  C07C77/02 ,  C07C79/02

CPC classification number: C07C201/02 ,  C07C45/33 ,  C07C45/36 ,  C07C51/316 ,  C07C201/04 ,  C07C201/06 ,  C07C2601/14 ,  C07C203/02 ,  C07C203/00 ,  C07C205/06 ,  C07C205/02

Abstract: THIS INVENTION RELATES TO THE RELATIVELY LOW TEMPERATURE TREATMENT OF HYDROCARBONS WITH NITRIC OIDE (NO) AND OXYGEN TO RPODUCE NITRATES, NITRITES AND KETONES AND OTHER OXIDATION PRODUCTS. THROUGH THE USE OF ALKALINE INHIBITORS SUCH AS ALKALI METAL BICARBONATES, THE PRODUCTION OF KETONES AND OTHER NON-NITROGEN CONTAINING OXIDATION PRODUCTS CAN BE MINIMIZED WHILE THE PRODUCTION OF ITRATES AND NITRIES ARE MAXIMIZED.

公开(公告)号：US3607877A

公开(公告)日：1971-09-21

申请号：US3607877D

申请日：1968-10-31

Applicant: DOW CHEMICAL CO

Inventor： DOMENICO PENELOPE B

IPC: C07B43/02 ,  C07C201/04 ,  C07C201/10 ,  C07C205/06 ,  C07C205/10 ,  C07C205/12 ,  C07C205/57 ,  C07D213/61 ,  C07D213/71 ,  C07D213/79 ,  C07D213/84 ,  C07D31/40

CPC classification number: C07D213/79 ,  C07B43/02 ,  C07C201/10 ,  C07C303/22 ,  C07C319/20 ,  C07D213/61 ,  C07D213/71 ,  C07D213/84 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C205/57 ,  C07C309/40 ,  C07C323/09

Abstract: A process is disclosed for converting aromatic thiols to the corresponding nitroso- or nitro-substituted compounds by treating the thiol compounds with an excess of nitric acid having a HNO3 concentration of 90 to 100 percent. Representative starting compounds are benzenethiols and pyridinethiols which, in addition to the thiol group, are substituted with one or more electronwith-drawing groups such, for example, as chloro, nitro or cyano, among others. The nitroso and nitro compounds produced during the reaction have utility as pesticides and are variously effective as herbicides and in the control of fungi and nematodes as well as of parasites infecting warmblooded animals.

公开(公告)号：US3520744A

公开(公告)日：1970-07-14

申请号：US3520744D

申请日：1969-02-27

Applicant: ICI LTD

Inventor： THOMAS HUGH ,  TURBET JOHN

IPC: C06B25/00 ,  C06B25/32 ,  C07C67/00 ,  C07C201/00 ,  C07C201/04 ,  C07C203/04 ,  C07C205/04 ,  C06B3/00

CPC classification number: C07C203/04 ,  C06B25/32

公开(公告)号：US09844599B2

公开(公告)日：2017-12-19

申请号：US14761887

申请日：2014-01-17

Applicant: Apparao Satyam

Inventor： Apparao Satyam

IPC: A61K31/21 ,  A61K31/60 ,  C07D201/04 ,  A61K47/48 ,  C07C229/42 ,  C07C201/04 ,  C07C227/18 ,  A61K31/216 ,  A61K31/621 ,  C07C203/04

CPC classification number: A61K47/542 ,  A61K31/21 ,  A61K31/216 ,  A61K31/60 ,  A61K47/55 ,  C07C201/04 ,  C07C203/04 ,  C07C227/18 ,  C07C229/42

Abstract: The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these produgs.

公开(公告)号：US20150328323A1

公开(公告)日：2015-11-19

申请号：US14761887

申请日：2014-01-17

Applicant: Apparao SATYAM

Inventor： Apparao Satyam

IPC: A61K47/48 ,  C07C229/42 ,  C07C227/18 ,  A61K31/621 ,  A61K31/216 ,  C07C201/04 ,  C07C203/04 ,  A61K45/06

CPC classification number: A61K47/542 ,  A61K31/21 ,  A61K31/216 ,  A61K31/60 ,  A61K47/55 ,  C07C201/04 ,  C07C203/04 ,  C07C227/18 ,  C07C229/42

Abstract: The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these produgs.

Abstract translation: 本发明涉及已知药物或治疗剂的一氧化氮释放前药，其中药物或治疗剂含有至少一个羧酸基团。 本发明还涉及制备这些一氧化氮释放前体药物的方法，含有它们的药物组合物以及使用这些产品的方法。

公开(公告)号：US5649322A

公开(公告)日：1997-07-15

申请号：US571625

申请日：1995-12-11

Applicant: Heinz Landscheidt ,  Paul Wagner ,  Zoltan Kricsfalussy ,  Alexander Klausener

Inventor： Heinz Landscheidt ,  Paul Wagner ,  Zoltan Kricsfalussy ,  Alexander Klausener

IPC: C07C201/04 ,  C07C203/00 ,  C07C203/02

CPC classification number: C07C201/04

Abstract: C.sub.1 -C.sub.4 -Alkyl nitrites can be prepared by reaction of C.sub.1 -C.sub.4 -alkanols with nitrogen oxides with the participation of oxygen in a reactor designed as a scrubber column, nitrogen oxides having a proportion of more than 50% of NO of the total amount of gram atoms of N of the nitrogen oxides, oxygen and optionally inert gas being fed into the lower part of the reactor. 5 to 60% of the total amount of C.sub.1 -C.sub.4 -alkanol used is likewise fed into the lower part of the reactor in vaporous or atomized form, while the remaining C.sub.1 -C.sub.4 -alkanol is delivered to the column head.

Abstract translation: C1-C4烷基亚硝酸盐可以通过在设计为洗涤塔的反应器中将C1-C4-链烷醇与氮氧化物反应而制备，氧化反应设计为总量超过NO的50％ 的氮原子的氮原子的克原子，氧和任选的惰性气体被供给到反应器的下部。 使用的C 1 -C 4烷醇的总量的5-60％同样以蒸气或雾化的形式进料到反应器的下部，而剩余的C1-C4-链烷醇被输送到塔头。

公开(公告)号：US5543548A

公开(公告)日：1996-08-06

申请号：US273548

申请日：1994-07-11

Applicant: Heinz Landscheidt ,  Erich Wolters ,  Paul Wagner ,  Alexander Klausener

Inventor： Heinz Landscheidt ,  Erich Wolters ,  Paul Wagner ,  Alexander Klausener

IPC: C07B61/00 ,  C07C31/04 ,  C07C68/00 ,  C07C68/08 ,  C07C69/96 ,  C07C201/04 ,  C07C203/00

CPC classification number: C07C68/00

Abstract: Dimethyl carbonate (DMC) is prepared by continuous gas reaction of carbon monoxide and methyl nitrite a heterogeneous catalyst comprising a platinum at 50.degree. to 170.degree. C. under 1 to 5 bar.

Abstract translation: 通过一氧化碳和亚硝酸甲酯的连续气相反应制备碳酸二甲酯（DMC），该催化剂在1至5巴下在50至170℃下包含铂。

公开(公告)号：US4879401A

公开(公告)日：1989-11-07

申请号：US102370

申请日：1987-09-29

Applicant: Arthur R. Doumaux, Jr. ,  James R. Nelson

Inventor： Arthur R. Doumaux, Jr. ,  James R. Nelson

IPC: C07C201/16 ,  C07C67/00 ,  C07C201/00 ,  C07C201/04 ,  C07C203/00 ,  C07C203/02 ,  C07C203/04

CPC classification number: C07C201/04

Abstract: A process is provided for removing impurities from the gaseous product of an alkyl nitrite production zone by contacting a portion of it with lower alcohol and oxygen to convert substantially all of the nitric oxide in that portion of the gaseous product stream to alkyl nitrite, the oxygen being present in an amount such that the mole ratio of nitric oxide to oxygen is in the range of about 4:1 to about 2:1 and the lower alcohol being present in the reaction zone such that the mole ratio of nitric oxide to lower alcohol is about 1:1 or less. A recovery stream, comprising alkyl nitrite substantially free of nitric oxide, is withdrawn from the reaction zone and at least a portion of the alkyl produced in the reaction zone is removed. A least a portion of the balance of the recovery stream from which the alkyl nitrite has been removed is purged, thereby removing impurities from the process.

Abstract translation: 提供了一种通过使其一部分与低级醇和氧接触而从亚硝酸烷基酯生产区的气态产物中除去杂质的方法，以将该部分气态产物流中的所有一氧化氮转化为亚硝酸烷基酯，氧气 存在的量使得一氧化氮与氧的摩尔比在约4:1至约2:1的范围内，低级醇存在于反应区中，使得一氧化氮与低级醇的摩尔比 约为1：1或更少。 包含基本上不含一氧化氮的亚硝酸烷基酯的回收流从反应区中排出，并且除去反应区中产生的烷基的至少一部分。 将亚硝酸烷基酯从其中除去的回收料流的余量的至少一部分被清除，从而从该方法中除去杂质。