公开(公告)号：US20250059176A1

公开(公告)日：2025-02-20

申请号：US18938776

申请日：2024-11-06

Applicant: GUANGZHOU INNOCARE PHARMA TECH CO., LTD.

Inventor： Xiangyang CHEN ,  Yingxiang GAO ,  Chong LIU ,  Haihong NI

IPC: C07D417/04 ,  A61K31/444 ,  A61P35/00 ,  C07D211/34 ,  C07D213/82 ,  C07D231/14 ,  C07D277/56 ,  C07D295/185 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04

Abstract: Compounds of Formula I, as shown below and defined herein: and pharmaceutically acceptable salts, syntheses, intermediates, formulations, and methods of treating diseases including cancer, inflammation, and autoimmune disease mediated at least in part by Bruton's Tyrosine Kinase (BTK).

公开(公告)号：US12227498B2

公开(公告)日：2025-02-18

申请号：US17269325

申请日：2019-08-27

Applicant: Daewoong Pharmaceutical Co., Ltd.

Inventor： Wol Young Kim ,  Yeon Im Lee ,  Youn Jung Yoon ,  Joon Seok Park ,  Deok Ki Eom ,  Keuk-Chan Bang ,  Jaehyun Jung

IPC: C07D417/14 ,  C07D413/04 ,  C07D471/04 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/506 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D403/14 ,  C07D417/12 ,  C07D487/04

Abstract: The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers. wherein, in Chemical Formula 1, R1, R2, X1, X2, L, Y, A and B are the same as defined in the specification.

公开(公告)号：US12227493B2

公开(公告)日：2025-02-18

申请号：US18348114

申请日：2023-07-06

Applicant: Insilico Medicine IP Limited

Inventor： Aleksandr Aliper ,  Vladimir Aladinskiy ,  Aleksandrs Zavoronkovs

IPC: C07D405/04 ,  A61K31/4164 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/048

Abstract: A method of inhibiting TNIK and/or MAP4K4 kinase can include: contacting the kinase with a compound of Formula A, wherein: ring 1 is an aromatic ring with or without hetero atoms; ring 2 is a hetero aromatic ring; ring 3 includes at least one hetero aromatic ring and optionally at least one cycloaliphatic ring fused with the at least one hetero aromatic ring; ring 4 is an aromatic ring with or without hetero atoms; Y is a bond or a linker; Y1 is a linker; each n is independently 0, 1, or 2; each o is independently 0. 1, 2, 3, 4, or 5; each R1, R6, R11, and R12 is independently a substituent; and RA is a ring structure, straight aliphatics, or branched aliphatics, which can be substituted or unsubstituted, any with or without hetero atoms.

公开(公告)号：US20250051317A1

公开(公告)日：2025-02-13

申请号：US18718395

申请日：2023-05-31

Applicant: SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD.

Inventor： Xianbin XU ,  Lei YANG

IPC: C07D413/04 ,  C07B59/00 ,  C07D263/56 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  H10K85/60

Abstract: The present application relates to the technical field of organic electroluminescent materials, and provides a nitrogen-containing compound, an organic electroluminescent device comprising same, and an electronic apparatus. The nitrogen-containing compound of the present application comprises a parent nucleus structure of a benzophenoxazole/thiazole group. When the nitrogen-containing compound is used as a host material for an emission layer of the organic electroluminescent device, the luminous efficiency and service life of the device can be remarkably improved.

公开(公告)号：US20250042887A1

公开(公告)日：2025-02-06

申请号：US18716093

申请日：2022-12-07

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： Yossef AV-GAY ,  Tirosh SHAPIRA ,  Steven PELECH ,  François JEAN

IPC: C07D413/04 ,  A61K31/4245 ,  A61P31/14

Abstract: Provided herein are compounds that inhibit glycogen synthase kinase-3 (GSK3) giving them antiviral activity. In particular, the invention relates to a subset of compounds represented by Formulas (I) and (II), for use as antiviral agents in the treatment or prevention of viral infection. Methods for using the GSK3 inhibitor compounds in the treatment or prophylaxis of a viral infection are provided. In particular, the viral infection may be selected from one or more of the following: Severe Acute Respiratory Syndrome (SARS) coronavirus-1 SARS-CoV-1) infection; SARS coronavirus-2 (SARS-CoV-2) infection; and Middle East Respiratory Syndrome (MFRS) coronavirus (MERS-CoV) infection. More specifically, the viral infection may be a human coronavirus 229E (HCoV-229E) infection.

公开(公告)号：US20250042853A1

公开(公告)日：2025-02-06

申请号：US18706666

申请日：2022-11-03

Applicant: BETTA PHARMACEUTICALS CO., LTD

Inventor： Rongwen YANG ,  Yun SUN ,  Jian ZHANG ,  Xuegang YI ,  Teng MA ,  Yu WANG ,  Pingping WANG ,  Lieming DING ,  Hong LAN ,  Jiabing WANG

IPC: C07D209/22 ,  A61K31/403 ,  A61K31/407 ,  A61K31/437 ,  A61K31/4709 ,  C07D209/30 ,  C07D209/52 ,  C07D401/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D491/052

Abstract: The present invention relates to a compound as shown in formula (I). The present invention also provides a composition and preparation containing the compound, and a method for using and preparing the compound.

公开(公告)号：US20250034124A1

公开(公告)日：2025-01-30

申请号：US18892072

申请日：2024-09-20

Applicant: JANSSEN PHARMACEUTICA NV

Inventor： Iwona WRONA ,  Kerem OZBOYA ,  Matthew LUCAS ,  Bhaumik PANDYA ,  Bertrand LE BOURDONNEC

IPC: C07D413/14 ,  A61K31/495 ,  A61P35/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

公开(公告)号：US12209072B2

公开(公告)日：2025-01-28

申请号：US17276176

申请日：2019-09-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Shi ,  Yan Shi ,  Hao Zhang

IPC: C07D261/08 ,  C07D249/06 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14

Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20240425501A1

公开(公告)日：2024-12-26

申请号：US18702429

申请日：2022-10-20

Applicant: Sanjita SASMAL ,  Venkatesham BOORGU ,  Ashok ETTAM ,  SATYARX PHARMA INNOVATIONS PVT LTD

Inventor： Sanjita SASMAL ,  Venkatesham BOORGU ,  Ashok ETTAM

IPC: C07D471/04 ,  A61K31/5025 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  C07D403/04 ,  C07D413/04

Abstract: The present invention relates to novel compounds of formula (I) which are inhibitors of SOS1:KRAS interaction, their pharmaceutically acceptable esters, salts, solvates, isomers thereof. The present invention specifically relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or a pharmaceutically acceptable regioisomer thereof and processes for their preparation.

公开(公告)号：US12171231B2

公开(公告)日：2024-12-24

申请号：US17611977

申请日：2020-06-19

Applicant: NIHON NOHYAKU CO., LTD.

Inventor： Naoya Fujita ,  Yutaka Kato

IPC: A01N43/82 ,  A01P3/00 ,  C07D413/04

Abstract: In production of crops of agriculture and horticulture or the like, damage caused by diseases is still large, and, due to factors such as occurrence of resistant diseases to existing drugs, development of new agrohorticultural fungicides is desired. The present invention provides an agrohorticultural fungicide and a method of use thereof, an active ingredient thereof being a compound represented by the general formula (I) or salts thereof: {wherein R1 denotes a hydrogen atom or (C1-C6)alkyl group or the like. R2 denotes a hydrogen atom or the like. R3 denotes a hydrogen atom or (C1-C6)alkyl group or the like. R4 denotes a (C1-C6)alkyl group, (C3-C6)cycloalkyl group or aryl group or the like. X1 and X2 denote a hydrogen atom or halogen atom or the like. Y denotes an oxygen atom.}.