公开(公告)号：US11472833B2

公开(公告)日：2022-10-18

申请号：US17256777

申请日：2019-07-03

申请人： Drawbridge Pharmaceuticals Pty Ltd

发明人： Ian Edmonds ,  Edward J. Hessler

IPC分类号： C07J75/00 ,  B01J23/46 ,  C07J7/00 ,  B01J23/44

摘要： Neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same are disclosed. Also provided are scaled up and/or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.

公开(公告)号：US20210188898A1

公开(公告)日：2021-06-24

申请号：US17191281

申请日：2021-03-03

申请人： Trustees of Dartmouth College

发明人： Glenn C. Micalizio

IPC分类号： C07J75/00 ,  C07J1/00

摘要： The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.

公开(公告)号：US11008363B2

公开(公告)日：2021-05-18

申请号：US16856374

申请日：2020-04-23

申请人： ALLERGAN SALES, LLC

发明人： Achampeta Rathan Prasad ,  Roy A. Swaringen, Jr. ,  John Gregory Reid ,  Robert M. Moriarty ,  Akhila Kumar Sahoo

IPC分类号： C07J9/00 ,  C07J75/00 ,  C07J1/00 ,  C07J13/00

摘要： Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.

公开(公告)号：US10800730B2

公开(公告)日：2020-10-13

申请号：US16136830

申请日：2018-09-20

申请人： The Board of Trustees of the University of Illinois

发明人： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

IPC分类号： C07C69/757 ,  C07J21/00 ,  C07J69/00 ,  C07J71/00 ,  C07J73/00 ,  C07J75/00 ,  C07D401/14 ,  C07D311/94 ,  C07D313/06 ,  C07D223/14 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07D303/10 ,  C07B37/06 ,  C07B37/08 ,  C07D307/93 ,  C07D313/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

公开(公告)号：US10597602B2

公开(公告)日：2020-03-24

申请号：US16073437

申请日：2017-01-26

申请人： Stora Enso OYJ

发明人： Jari Kavakka

IPC分类号： C11B3/00 ,  B01D11/04 ,  C11B3/12 ,  D21C11/00 ,  C07J9/00 ,  B01D3/14 ,  C07J75/00

摘要： The present invention relates to extraction of phytosterols from alkaline tall oil soap which is obtained from the Kraft process black liquor by skimming. In the method according to the present invention, phytosterols are extracted using dibromomethane, bromoform, tetrabromomethane or a combination thereof.

公开(公告)号：US10202413B2

公开(公告)日：2019-02-12

申请号：US14767235

申请日：2014-02-14

申请人： Washington University

发明人： Douglas Covey

IPC分类号： A61K31/56 ,  A61K31/566 ,  A61K31/568 ,  A61K31/5685 ,  C07J1/00 ,  C07J21/00 ,  C07J15/00 ,  C07J41/00 ,  C07C35/42 ,  C07J13/00 ,  C07J31/00 ,  C07J51/00 ,  C07J61/00 ,  C07J63/00 ,  C07J71/00 ,  C07J75/00 ,  C07C43/307

摘要： The present disclosure is generally directed to neuroactive enantiomeric 15-, 16- and 17-substituted steroids with additional optional substituents at carbons 3, 4, 6, 7, 10 and 13, and pharmaceutically acceptable salts thereof, for use as, for example, modulators for GABA type-A receptors. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

公开(公告)号：US20190010420A1

公开(公告)日：2019-01-10

申请号：US16073437

申请日：2017-01-26

申请人： Stora Enso OYJ

发明人： Jari Kavakka

IPC分类号： C11B3/00 ,  C11B3/12 ,  C07J75/00 ,  B01D3/14 ,  B01D11/04

CPC分类号： C11B3/006 ,  B01D3/143 ,  B01D11/0492 ,  B01D2257/2062 ,  C07J9/00 ,  C07J75/00 ,  C11B3/12 ,  D21C11/00

摘要： The present invention relates to extraction of phytosterols from alkaline tall oil soap which is obtained from the Kraft process black liquor by skimming. In the method according to the present invention, phytosterols are extracted using dibromomethane, bromoform, tetrabromomethane or a combination thereof.

公开(公告)号：US10072030B2

公开(公告)日：2018-09-11

申请号：US15375716

申请日：2016-12-12

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Anton Toutov ,  Kerry Betz ,  Brian M. Stoltz ,  Wenbo Liu ,  Robert H. Grubbs

IPC分类号： C07F7/08 ,  C07J1/00 ,  C07J51/00 ,  C07F17/02 ,  C07J7/00 ,  C07J75/00

CPC分类号： C07F7/0827 ,  C07F17/02 ,  C07J1/0096 ,  C07J7/0005 ,  C07J51/00 ,  C07J75/00

摘要： The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, alkali metal alkoxide, or alkali metal hydride under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the presence or substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.

公开(公告)号：US20170088563A1

公开(公告)日：2017-03-30

申请号：US15375716

申请日：2016-12-12

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： ANTON TOUTOV ,  KERRY BETZ ,  BRIAN M. STOLTZ ,  WENBO LIU ,  ROBERT H. GRUBBS

IPC分类号： C07F7/08 ,  C07J75/00 ,  C07J7/00 ,  C07F17/02

CPC分类号： C07F7/0827 ,  C07F17/02 ,  C07J1/0096 ,  C07J7/0005 ,  C07J51/00 ,  C07J75/00

摘要： The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, alkali metal alkoxide, or alkali metal hydride under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the presence or substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.

公开(公告)号：US09556222B2

公开(公告)日：2017-01-31

申请号：US14406854

申请日：2013-06-14

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Christopher F. Bender ,  Xin Jiang ,  Xiaofeng Liu ,  Haizhou Sun ,  Melean Visnick

IPC分类号： C07J71/00 ,  C07J75/00 ,  C07D493/22 ,  A61K31/336 ,  C07J63/00

CPC分类号： C07J71/001 ,  A61K31/336 ,  C07D493/22 ,  C07J63/008 ,  C07J75/00

摘要： Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.

摘要翻译： 本文公开了新型的A环环氧化三萜化合物及其衍生物，包括式（I）的那些，其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用化合物的方法，例如抗氧化剂炎症调节剂及其组合物。