公开(公告)号：US20140194709A1

公开(公告)日：2014-07-10

申请号：US14103431

申请日：2013-12-11

Applicant: Cercacor Laboratories, Inc.

Inventor： Ammar Al-Ali ,  Massi Joe E. Kiani ,  Walter M. Weber

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B1/00 ,  A61B5/0022 ,  A61B5/0205 ,  A61B5/02416 ,  A61B5/02427 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/1495 ,  A61B5/6815 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6832 ,  A61B5/6838 ,  A61B5/7221 ,  A61B5/7246 ,  A61B5/7275 ,  A61B5/7278 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/746 ,  A61B5/7475 ,  A61B2562/08 ,  A61B2562/085 ,  A61B2562/222 ,  G06F19/00 ,  G06F19/3418 ,  Y10S439/909

Abstract: A physiological measurement system has a sensor, a processor, a communications link and information elements. The sensor is configured to transmit light having a plurality of wavelengths into a tissue site and to generate a sensor signal responsive to the transmitted light after tissue attenuation. The attenuated light can be used by the system to determine a plurality of physiological measurements. The processor is configured to operate on the sensor signal so as to derive at least one physiological parameter after which of the plurality of physiological measurements the system is configured to or capable of measuring.

Abstract translation: 生理测量系统具有传感器，处理器，通信链路和信息元素。 传感器被配置为将具有多个波长的光透射到组织部位中，并且在组织衰减之后响应于透射光产生传感器信号。 衰减的光可以被系统用于确定多个生理测量。 所述处理器被配置为对所述传感器信号进行操作，以便导出至少一个生理参数，所述多个生理测量中的所述多个生理测量之一被配置为或能够测量。

公开(公告)号：US20140129702A1

公开(公告)日：2014-05-08

申请号：US14071447

申请日：2013-11-04

Applicant: Cercacor Laboratories, Inc.

Inventor： Marcelo M. Lamego ,  Jeroen Poeze

IPC: H04L12/26

CPC classification number: H04L43/16 ,  A61B5/0002 ,  A61B5/14551 ,  A61B2560/028 ,  G06F19/00 ,  G06F19/3418 ,  G06Q20/145 ,  G06Q50/22

Abstract: A physiological test credit method determines if test credits are available to the monitor and checks if a Wi-Fi connection is available. If test credits are less than a test credit threshold, the monitor connects to a test credit server, processes server commands so as to download test credits and disconnects from the server. In various embodiments, the monitor is challenged to break a server code, the server is challenged to break a monitor code. The server validates monitor serial codes, and saves monitor configuration parameters.

Abstract translation: 生理测试信用方法确定测试信用是否可用于监视器，并检查Wi-Fi连接是否可用。 如果测试信用度低于测试信用阈值，则监视器连接到测试信用服务器，处理服务器命令，以便下载测试信用和从服务器断开连接。 在各种实施例中，监视器面临破坏服务器代码的挑战，服务器面临破坏监视器代码的挑战。 服务器验证监控序列号，并保存监控配置参数。

公开(公告)号：US20140127137A1

公开(公告)日：2014-05-08

申请号：US13919923

申请日：2013-06-17

Applicant: Cercacor Laboratories, Inc

Inventor： Emile M. Bellott ,  Dongsheng Bu ,  James J. Childs ,  Christopher Lambert ,  Hubert A. Nienaber ,  Shirley J. Shi ,  Zhaolin Wang ,  Jerome J. Workman ,  Alex R. Zelenchuk

IPC: A61K49/00 ,  C07F5/02

CPC classification number: A61K49/0052 ,  A61K49/0021 ,  A61K49/0041 ,  C07F5/025 ,  C07F7/1804 ,  Y10T436/144444

Abstract: Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

Abstract translation: 描述用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

公开(公告)号：US20140121482A1

公开(公告)日：2014-05-01

申请号：US14064055

申请日：2013-10-25

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Sean Merritt ,  Marcelo Lamego ,  Cristiano Dalvi ,  Hung Vo ,  Johannes Bruinsma ,  Jeroen Poeze ,  Ferdyan Lesmana ,  Massi Joe E. Kiani

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61B5/6843 ,  A61B2562/0233 ,  A61B2562/04 ,  A61B2562/046 ,  A61B2562/146

Abstract: The present disclosure relates to a sensor having a set of photodetectors that are arranged at various locations to enable the measurement of blood glucose. The photodetectors are arranged across multiple locations. For example, the detector may comprise multiple photodetector arrays that are arranged to have a sufficient difference in mean path length to allow for noise cancellation and noise reduction. Walls may be used in the detector to separate individual photodetectors and prevent mixing of detected optical radiation between the different locations on the measurement site. A window may also be employed to facilitate the passing of optical radiation at various wavelengths for measuring glucose in the tissue.

Abstract translation: 本公开涉及具有一组光电检测器的传感器，其被布置在各种位置以能够测量血糖。 光电探测器布置在多个位置。 例如，检测器可以包括多个光电检测器阵列，其布置成在平均路径长度上具有足够的差异以允许噪声消除和降噪。 可以在检测器中使用壁来分离各个光电检测器，并防止检测的光辐射在测量位置上的不同位置之间的混合。 还可以使用窗口来促进用于测量组织中葡萄糖的各种波长的光辐射的通过。

公开(公告)号：US20140088388A1

公开(公告)日：2014-03-27

申请号：US14042519

申请日：2013-09-30

Applicant: Cercacor Laboratories, Inc.

Inventor： Ammar Al-Ali ,  Yassir Abdul-Hafiz

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14552 ,  A61B5/02427 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6831 ,  A61B5/6832 ,  A61B5/6838 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2562/085 ,  A61B2562/12 ,  A61B2562/164 ,  Y10T29/49826

Abstract: An embodiment of the present disclosure provides a noninvasive optical sensor or probe including disposable and reusable components. The assembly of the disposable and reusable components is straightforward, along with the disassembly thereof. During application to a measurement site, the assembled sensor is advantageously secured together while the componentry is advantageously properly positioned.

Abstract translation: 本公开的一个实施例提供了包括一次性和可重复使用的部件的无创光学传感器或探针。 一次性和可重复使用的部件的组装与其拆卸一起是简单的。 在施加到测量位置期间，组装的传感器有利地固定在一起，同时有利地适当地定位组件。

公开(公告)号：US20130317370A1

公开(公告)日：2013-11-28

申请号：US13888266

申请日：2013-05-06

Applicant: Cercacor Laboratories, Inc.

Inventor： Cristiano Dalvi ,  Marcelo Lamego ,  Sean Merritt ,  Hung Vo ,  Johannes Bruinsma ,  Jeroen Poeze ,  Ferydan Lesmana ,  Greg Olsen ,  Massi Joe E. Kiani

IPC: A61B5/024 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/02427 ,  A61B5/02416 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/4875 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61B5/6843 ,  A61B5/70 ,  A61B5/7275 ,  A61B2562/146

Abstract: A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.

Abstract translation: 用于测量医疗患者的一个或多个生理参数的无创生理传感器可以包括插入在光源和光电检测器之间的凸块。 凸起可以放置成与患者的身体组织接触，从而减少身体组织的厚度。 结果，可以减少光源和光电检测器之间的光程。 此外，传感器可以包括可将热量远离光源引导的散热器。 此外，传感器可以包括在光源和光电检测器之间的光路中的屏蔽。 屏蔽可以降低由光电检测器接收的噪声。

公开(公告)号：US20130178749A1

公开(公告)日：2013-07-11

申请号：US13764007

申请日：2013-02-11

Applicant: CERCACOR LABORATORIES, INC.

Inventor： Marcelo Lamego

IPC: A61B5/024 ,  A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/14551 ,  A61B5/02416 ,  A61B5/0295 ,  A61B5/72 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/746 ,  A61B5/7475

Abstract: A tissue profile wellness monitor measures a physiological parameter, generates a tissue profile, defines limits and indicates when the tissue profile exceeds the defined limits. The physiological parameter is responsive to multiple wavelengths of optical radiation after attenuation by constituents of pulsatile blood flowing within a tissue site. The tissue profile is responsive to the physiological parameter. The limits are defined for at least a portion of the tissue profile.

公开(公告)号：US20240164668A1

公开(公告)日：2024-05-23

申请号：US18520380

申请日：2023-11-27

Applicant: Cercacor Laboratories, Inc.

Inventor： Kevin Pauley ,  Cristiano Dalvi ,  Hung Vo ,  Jesse Chen ,  Ferdyan Lesmana ,  Jeroen Poeze ,  Sean Merritt

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  G01J1/16 ,  G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  G01N21/59

CPC classification number: A61B5/14552 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/4875 ,  G01J1/1626 ,  G01N21/31 ,  G01N21/4738 ,  G01N21/49 ,  G01N21/59 ,  A61B2562/0238 ,  G01J2001/1636 ,  G01J2001/1652 ,  G01N2021/3181

Abstract: An optical measurement device includes a light source, a first detector, and a second detector. The light source emits light to a measurement site of a patient and one or more detectors detect the light from the light source. At least a portion of a detector is translucent and the light passes through the translucent portion prior to reaching the measurement site. A detector receives the light after attenuation and/or reflection or refraction by the measurement site. A processor determines a light intensity of the light source, a light intensity through a tissue site, or a light intensity of reflected or refracted light based on light detected by the one or more detectors. The processor can estimate a concentration of an analyte at the measurement site or an absorption or reflection at the measurement site.

公开(公告)号：US11864922B2

公开(公告)日：2024-01-09

申请号：US18045970

申请日：2022-10-12

Applicant: Cercacor Laboratories, Inc.

Inventor： Cristiano Dalvi ,  Jeroen Poeze

IPC: A61B5/00 ,  A61B5/026 ,  A61B5/1491 ,  A61B5/1455

CPC classification number: A61B5/7203 ,  A61B5/0261 ,  A61B5/1491 ,  A61B5/14552 ,  A61B5/7278 ,  A61B2560/0214 ,  A61B2562/185 ,  A61B2562/222 ,  A61B2562/227

Abstract: A sensor system has a low-noise sensor controller providing communications between an active-temperature-regulated optical sensor and an external monitor. A low-noise sensor controller drives optical emitters, receives resulting detected signals after attenuation by a blood perfused tissue site and communicates the detector signals to the attached signal processor. An optically-isolated controller front-end receives and digitizes the detected signals. A controller serializer transmits the digitized detector signal to the processor via a single, shielded coaxial cable.

公开(公告)号：US11864890B2

公开(公告)日：2024-01-09

申请号：US16985497

申请日：2020-08-05

Applicant: Cercacor Laboratories, Inc.

Inventor： Kevin Pauley ,  Cristiano Dalvi ,  Hung Vo ,  Jesse Chen ,  Ferdyan Lesmana ,  Jeroen Poeze ,  Sean Merritt

IPC: A61B5/1455 ,  A61B5/145 ,  G01J1/16 ,  G01N21/47 ,  G01N21/31 ,  G01N21/49 ,  A61B5/00 ,  G01N21/59

CPC classification number: A61B5/14552 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/4875 ,  G01J1/1626 ,  G01N21/31 ,  G01N21/4738 ,  G01N21/49 ,  G01N21/59 ,  A61B2562/0238 ,  G01J2001/1636 ,  G01J2001/1652 ,  G01N2021/3181

Abstract: An optical measurement device includes a light source, a first detector, and a second detector. The light source emits light to a measurement site of a patient and one or more detectors detect the light from the light source. At least a portion of a detector is translucent and the light passes through the translucent portion prior to reaching the measurement site. A detector receives the light after attenuation and/or reflection or refraction by the measurement site. A processor determines a light intensity of the light source, a light intensity through a tissue site, or a light intensity of reflected or refracted light based on light detected by the one or more detectors. The processor can estimate a concentration of an analyte at the measurement site or an absorption or reflection at the measurement site.