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    Neutralizing RNA aptamers
    92.
    发明授权
    Neutralizing RNA aptamers 有权
    中和RNA适体

    公开(公告)号：US09234202B2

    公开(公告)日：2016-01-12

    申请号：US14433386

    申请日：2013-10-04

    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

    Inventor： Laura Cerchia ,  Gerolama Condorelli ,  Vittorio De Franciscis

    IPC: C12N15/115

    CPC classification number: C12N15/115 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/344 ,  C12N2310/3533

    Abstract: Nuclease-resistant RNA aptamers are provided which are capable of neutralizing PDGFRβ and are therefore useful in the diagnosis and/or therapy of PDGFRβ-associated and hyperproliferative-associated diseases, such as cancer and primary tumor metastasis. RNA aptamers provided herein include a modified synthetic RNA sequence wherein at least one pyrimidine residue is modified to 2′-fluoropyrimidine. Pharmaceutical compositions and diagnostic kits comprising RNA aptamers are also provided.

    Abstract translation: 提供了能够中和PDGFR和bgr的核酸酶抗性的RNA适体; 因此可用于诊断和/或治疗PDGFR和相关和过度增殖相关疾病，如癌症和原发性肿瘤转移。 本文提供的RNA适体包括修饰的合成RNA序列，其中至少一个嘧啶残基被修饰成2'-氟嘧啶。 还提供了包含RNA适体的药物组合物和诊断试剂盒。

    "> METHOD FOR REALIZING MONOATOMIC LAYERS OF CRYSTALLINE SILICIUM UPON A SUBSTRATE OF CRYSTALLINE
    93.
    发明申请
    METHOD FOR REALIZING MONOATOMIC LAYERS OF CRYSTALLINE SILICIUM UPON A SUBSTRATE OF CRYSTALLINE "BETA" - SILICIUM NITRIDE 审中-公开
    在晶体“BET” - 氮化硅基底上实现结晶硅单晶层的方法

    公开(公告)号：US20150194308A1

    公开(公告)日：2015-07-09

    申请号：US14410029

    申请日：2013-05-31

    Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

    Inventor： Roberto Flammini ,  Daniele Maria Trucchi

    IPC: H01L21/02

    CPC classification number: H01L21/02532 ,  C30B23/025 ,  C30B25/183 ,  C30B29/06 ,  H01L21/02255 ,  H01L21/02301 ,  H01L21/02381 ,  H01L21/02433 ,  H01L21/02488 ,  H01L21/0259 ,  H01L21/02598 ,  H01L21/02631 ,  H01L21/02661

    Abstract: Method for fabricating a structure comprising a monatomic layer of crystalline silicon upon an electrically insulating layer of crystalline silicon nitride in the β structural form, comprising the following steps: A. providing a standalone Si (111) substrate, said substrate comprising a first face and a second main face; B. thermally treating the substrate so that the Si (111) surface is clean, i.e. non contaminated at an atomic level; C. thermally growing a crystalline silicon nitride layer in the 13 structural form on at least one face of said Si (111) substrate; D. thermally growing a crystalline silicon monatomic layer on the crystalline silicon nitride layer.

    Abstract translation: 制造结构的结构的方法，该结构包括在“bgr”中的结晶氮化硅的电绝缘层上的晶体硅单原子层; 结构形式，包括以下步骤：A.提​​供独立的Si（111）衬底，所述衬底包括第一面和第二主面; B.对基底进行热处理，使得Si（111）表面是干净的，即在原子级不被污染; C.在所述Si（111）衬底的至少一个表面上以13结构形式热生长结晶氮化硅层; D.在结晶氮化硅层上热生长晶体硅单原子层。

    METHOD FOR THE ESTIMATING THE PRESENCE OF RAIN
    100.
    发明公开
    METHOD FOR THE ESTIMATING THE PRESENCE OF RAIN 审中-公开

    公开(公告)号：US20230296805A1

    公开(公告)日：2023-09-21

    申请号：US18006960

    申请日：2021-07-21

    Applicant: UNIVERSITA' DI PISA ,  CONSIGLIO NAZIONALE DELLE RICERCHE ,  M.B.I. S.R.L.

    Inventor： Filippo GIANNETTI ,  Ruggero REGGIANNINI ,  Marco MORETTI ,  Antonio COLICELLI

    IPC: G01W1/14

    CPC classification number: G01W1/14

    Abstract: It is provided aA method for estimating the presence of rain characterized by comprising including the steps of entering a set of static parameters, entering a set of dynamic parameters, measuring an instant value, sending said the values to a first Kalman filter and to a second Kalman filter and define defining the start of a precipitative event if a difference between said the KalmanST output and said the KalmanFT output exceeds said the “epsilonStart” threshold value and also define the term of a precipitative event if a difference between said the KalmanST output said the said KalmanFT output is lower than said the “epsilonStop” threshold value.

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