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    ARRAY-BASED POLYMORPHISM MAPPING AT SINGLE NUCLEOTIDE RESOLUTION
    92.
    发明申请
    ARRAY-BASED POLYMORPHISM MAPPING AT SINGLE NUCLEOTIDE RESOLUTION 审中-公开
    基于阵列的多核苷酸多态性分析

    公开(公告)号：US20090264307A1

    公开(公告)日：2009-10-22

    申请号：US12160266

    申请日：2007-01-12

    Applicant: David Gresham ,  David Botstein ,  Leonid Kruglyak ,  Douglas Ruderfer ,  Stephen Pratt

    Inventor： David Gresham ,  David Botstein ,  Leonid Kruglyak ,  Douglas Ruderfer ,  Stephen Pratt

    IPC: C40B30/04 ,  C12Q1/68 ,  C40B40/06

    CPC classification number: G16B25/00 ,  G16B20/00

    Abstract: Disclosed herein is a system useful for detecting sequence differences (e.g., single-nucleotide polymorphisms) between genomes using data from a single hybridization with a genomic DNA microarray, such as a whole-genome array. The methods described herein can be used to detect, simply and inexpensively, differences in sequence among the genomes of individual members of a species, for example. In examples described herein, the system and methods were used to detect a variety of spontaneous single base-pair substitutions, insertions and deletions, and most (>90%) of the approximately 30,000 known single-nucleotide polymorphisms between two Saccharomyces cerevisiae strains. The system and methods were also used to elucidate the genetic basis of phenotypic variants and identify the small number of single base-pair changes accumulated during experimental evolution of yeast.

    Abstract translation: 本文公开了可用于使用来自与基因组DNA微阵列（例如全基因组阵列）的单一杂交的数据来检测基因组之间的序列差异（例如，单核苷酸多态性）的系统。 本文描述的方法可以用于例如检测物种的个体成员的基因组之间的顺序差异的简单且廉价的检测。 在本文描述的实施例中，系统和方法用于检测各种自发单碱基对取代，插入和缺失，以及两个酿酒酵母菌株之间大约30,000个已知单核苷酸多态性（> 90％）的大多数（> 90％）。 系统和方法也用于阐明表型变异体的遗传基础，并确定在酵母实验进化过程中累积的单碱基对变化的数量少。

    POLYPEPTIDES SHARING SEQUENCE IDENTITY WITH A FIBROBLAST GROWTH FACTOR POLYPEPTIDE AND NUCLEIC ACIDS ENCODING THE SAME
    93.
    发明申请
    POLYPEPTIDES SHARING SEQUENCE IDENTITY WITH A FIBROBLAST GROWTH FACTOR POLYPEPTIDE AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
    多肽与纤维蛋白原生长因子多肽和核酸共编序列序列识别

    公开(公告)号：US20090098603A1

    公开(公告)日：2009-04-16

    申请号：US12273334

    申请日：2008-11-18

    Applicant: David BOTSTEIN ,  Audrey Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Margaret Ann Roy

    Inventor： David BOTSTEIN ,  Audrey Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Margaret Ann Roy

    IPC: C12P21/04 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K14/00 ,  C12N1/21 ,  C12N1/19

    CPC classification number: C07K14/50 ,  C07K2317/24 ,  C07K2319/00

    Abstract: The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.

    Abstract translation: 本发明涉及与PRO533蛋白质和编码这些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体，以及本发明多肽的制备方法 发明。 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生和/或自分泌信号传导。 因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 此外，进一步预期本发明的化合物，包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。

    POLYPEPTIDES SHARING SEQUENCE IDENTITY WITH A FIBROBLAST GROWTH FACTOR POLYPEPTIDE AND NUCLEIC ACIDS ENCODING THE SAME
    94.
    发明申请
    POLYPEPTIDES SHARING SEQUENCE IDENTITY WITH A FIBROBLAST GROWTH FACTOR POLYPEPTIDE AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
    多肽与纤维蛋白原生长因子多肽和核酸共编序列序列识别

    公开(公告)号：US20070077626A1

    公开(公告)日：2007-04-05

    申请号：US11611037

    申请日：2006-12-14

    Applicant: David Botstein ,  Audrey Goddard ,  Austin Gurney ,  Kenneth Hillan ,  David Lawrence ,  Margaret Roy

    Inventor： David Botstein ,  Audrey Goddard ,  Austin Gurney ,  Kenneth Hillan ,  David Lawrence ,  Margaret Roy

    IPC: C07K14/50 ,  C07H21/04 ,  C12P21/06

    CPC classification number: C07K14/50 ,  C07K2317/24 ,  C07K2319/00

    Abstract: The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.

    Abstract translation: 本发明涉及与PRO533蛋白质和编码这些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体，以及本发明多肽的制备方法 发明。 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生和/或自分泌信号传导。 因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 此外，进一步预期本发明的化合物，包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。

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