公开(公告)号：US20210253717A1

公开(公告)日：2021-08-19

申请号：US17174386

申请日：2021-02-12

Applicant: Janssen Biotech, Inc.

Inventor： Roland Knoblauch ,  Sylvie Laquerre ,  Sheri Moores

IPC: C07K16/28 ,  A61K45/06 ,  A61K31/53 ,  A61P35/00

Abstract: The present invention relates to treatment of subjects having a cancer that is positive for c-Met exon 14 skipping mutations.

公开(公告)号：US20210206825A1

公开(公告)日：2021-07-08

申请号：US17174524

申请日：2021-02-12

Applicant: Janssen Biotech, Inc.

Inventor： Mark Anderson ,  Ricardo Attar ,  Michael Diem ,  Linus Hyun ,  Steven Jacobs ,  Alastair King ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K14/705 ,  C07K14/78 ,  C07K14/71 ,  C07K16/28 ,  C07K14/47

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US20210179696A1

公开(公告)日：2021-06-17

申请号：US16986615

申请日：2020-08-06

Applicant: Janssen Biotech, Inc.

Inventor： Marc Mercken ,  Thomas Malia ,  Marianne Borgers ,  Kristof Van Kolen

IPC: C07K16/18 ,  A61P25/28 ,  G01N33/68 ,  A61K9/00 ,  C07K16/44

Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.

公开(公告)号：US20210174512A1

公开(公告)日：2021-06-10

申请号：US17115036

申请日：2020-12-08

Applicant: Janssen Biotech, Inc.

Inventor： Yanqing Chen ,  Charles Tang ,  Ernesto J. Munoz-Elias

IPC: G06T7/11

Abstract: An image processing method is provided that automatically calculates Body Surface Area (BSA) score using machine learning techniques. A Felzenszwalb image segmentation algorithm is used to define proposed regions in each of a plurality of training set images. The training set images are oversegmented, and then each of the proposed regions in each of the plurality of oversegmented training set images are manually classified as being a lesion or a non-lesion. A Convolutional Neural Network (CNN) is then trained using the manually classified proposed regions in each of the plurality of training set images. The trained CNN is then used on test images to calculate BSA scores.

公开(公告)号：US20210155711A1

公开(公告)日：2021-05-27

申请号：US17150269

申请日：2021-01-15

Applicant: Janssen Biotech, Inc.

Inventor： Stephen McCarthy ,  Bernard Scallon ,  William Strohl ,  Susan Tam ,  Omid Vafa

IPC: C07K16/32 ,  C07K16/00 ,  C07K16/28

Abstract: Antibody and other Fc-containing molecules with variations in the Fc region with reduced binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.

公开(公告)号：US20210145878A1

公开(公告)日：2021-05-20

申请号：US16950296

申请日：2020-11-17

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Elena LASORSA ,  Ulrike PHILIPPAR

IPC: A61K35/17 ,  A61P35/00 ,  C07K16/28

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a Cluster of Differentiation 79b protein (CD79b), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US10995149B2

公开(公告)日：2021-05-04

申请号：US15997148

申请日：2018-06-04

Applicant: Janssen Biotech, Inc.

Inventor： Qiang Chen ,  Suzanne Cole ,  Karen Duffy ,  Yanxia Guo ,  Debra Gardner ,  Damon Hamel ,  Shannon Hitchcock ,  Ann Lacombe ,  Jinquan Luo ,  Ravi Malaviya ,  Yevgeniya Orlovsky ,  Pejman Soroosh ,  Melissa Swiecki ,  Deepti Wilkinson

IPC: C07K16/40 ,  A61P37/06 ,  C07K16/06 ,  A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00

Abstract: Antibodies that specifically bind PD-1 or antigen binding fragments thereof, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of an inflammatory or immune disorder.

公开(公告)号：US20210107991A1

公开(公告)日：2021-04-15

申请号：US17116822

申请日：2020-12-09

Applicant: Janssen Biotech, Inc.

Inventor： Richard Jansson ,  Vineet Kumar

IPC: C07K16/28 ,  A61K38/47 ,  A61K47/12 ,  A61K47/02 ,  A61K47/26 ,  A61K47/22 ,  A61K47/20 ,  A61K9/00 ,  A61K45/06 ,  A61K39/395 ,  A61P35/00

Abstract: The present invention relates to subcutaneous formulations of anti-CD38 antibodies and their uses.

公开(公告)号：US20210093719A1

公开(公告)日：2021-04-01

申请号：US17089928

申请日：2020-11-05

Applicant: Janssen Biotech, Inc.

Inventor： Michael Quigley ,  Andressa Smith

IPC: A61K39/395 ,  A61K31/4439 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  A61K45/06 ,  A61K31/501

Abstract: The present invention is directed to methods for treating cancer, preferably a solid tumor or hematological malignancy, including for example pancreatic cancer, lung cancer (including but not limited to non-small cell lung cancer (NSCLC)), prostate cancer, colorectal cancer, breast cancer, melanoma or non-Hodgkin's lymphoma, comprising administering to a subject in need thereof a therapeutically effective amount of co-therapy comprising, consisting or consisting essentially of (a) a small molecule CSF-1R inhibitor and (b) an agonistic antibody that binds CD40.

公开(公告)号：US10961307B2

公开(公告)日：2021-03-30

申请号：US16580509

申请日：2019-09-24

Applicant: Janssen Biotech, Inc.

Inventor： Jewel Johanns ,  Katherine Li ,  Colleen Marano ,  Richard Strauss ,  Hongyan Zhang ,  Christopher O'Brien ,  Omoniyi Adedokun ,  Kimberly Shields-Tuttle

IPC: A61K39/00 ,  C07K16/24 ,  A61K9/08 ,  A61K47/22 ,  A61K47/26 ,  A61K47/18 ,  A61P1/04 ,  A61K9/00

Abstract: Described are methods and compositions for clinical proven safe and effective treatment of ulcerative colitis, particularly moderately to severely active ulcerative colitis in patients who have had an inadequate response to or are intolerant of a conventional or existing therapy by intravenous and/or subcutaneous administration of an anti-IL-12/IL-23p40 antibody.