Abstract:
This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
Abstract:
A computer-implemented system and method are disclosed for performing engineering review of energy consumption by one or more equipment. One or more computers are connected to a specifications database. The computers are configured to receive end-user configurations corresponding to first equipment; retrieve one or more second equipment, as well as second equipment specifications from the specifications database; calculate an invoicing statement for the second equipment; and provide an engineering review report of the energy savings realized by implementing the second equipment. The first equipment may be an existing equipment, while the second equipment is one or more energy-efficient replacement alternatives to the first equipment. Each step is performed in real-time, using automated software modules and sub-modules. The engineering review report is applicable as an instant approval or pre-approval, qualifying the end-user for purchase incentives, which apply when the energy-efficient equipment alternatives are adopted by the end-user.
Abstract:
The invention provides a set of mechanisms by which a wireless mobile mesh node equipped with a directional antenna may self form and self adapt its steady-state communications schedule. A link establishment handshake is carried out over an ongoing subtemplate-based discovery scan. During time not reserved for steady-state communications with previously discovered neighbors, nodes continue to search for an establish links with new neighbors. Initial and subsequent bandwidth allocation protocols may be utilized to allow peer nodes to coordinate communication opportunities between the peer nodes without impacting or having knowledge about reservations for communications with other peers. The link establishment and initial bandwidth allocation protocols may be piggy-backed for readily establishing an initial steady-state schedule with a peer upon link establishment without impact on previous steady state reservations by other nodes or on ongoing link establishment attempts elsewhere.
Abstract:
A Shipboard Auditory Sensor (SAS) for detection and classification of acoustic signaling at sea is capable of detecting whistles blasts from other vessels in accordance with Rules 34 and 35 of COLREGS to support autonomous operations in a maritime environment.
Abstract:
An energy conversion system includes rotor, stator and shell components configurations for increasing power efficiency and improving replacement and repair efficiency. The system harvests environmental energy for lower power generation and accounts for non-mechanical sources of rotational resistance within the generator.
Abstract:
A Shipboard Auditory Sensor (SAS) for detection and classification of acoustic signaling at sea is capable of detecting whistles blasts from other vessels in accordance with Rules 34 and 35 of COLREGS to support autonomous operations in a maritime environment.
Abstract:
The Adaptable Pulse Position Modulation (APPM) optical communication system and process facilitate wireless communications through turbid mediums including, but not limited to, smoke, airborne dust, mist, fog, clouds, water, seawater and water-to-air (air-to-water) interfaces by controlling the signal gain at the optical detector and controlling of the signal encoding to allow high data rate operation when the signal to noise ratio is high. The system also supports signal encoding redundancy to maintain good connectivity at the cost of the communication channel data rate as the signal to noise degrades.
Abstract:
A process, including a mobile application, for tracking the drayage driver and vehicle movement and reporting where the driver is and how much time he has been at a location, as well as details about the driver and cargo is described. This process can correlate driver and vehicle identification and allow for the transfer of bill of lading or hazardous material restrictions. Data captured is easily be made available in advance to the port terminals (which must have container ready for pick up); available for the shipping company (which can see cargo en-route—regardless of which company the driver works for); and available for the destination warehouse (which must receive and process the shipment). The association of cargo owners, shippers, terminal yards, drayage companies, drivers, and drayage job assignments can further be linked.
Abstract:
The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
Abstract:
A Volatile Organic Compound (VOC) mitigation system employs a combination of technologies coupling VOC laden exhaust with a reciprocating engine and generator system (Combined Heat & Power (CHP) System) with heat recovery to destroy the VOC emissions and generate electric power and useful thermal energy.