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公开(公告)号:US10762654B2
公开(公告)日:2020-09-01
申请号:US16675617
申请日:2019-11-06
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Jingyi Yu
Abstract: A method of generating a three-dimensional model of an object is disclosed. The method may use a light field camera to capture a plurality of light field images at a plurality of viewpoints. The method may include capturing a first light field image at a first viewpoint; capturing a second light field image at the second viewpoint; estimating a rotation and a translation of a light field from the first viewpoint to the second viewpoint; obtaining a disparity map from each of the plurality of light field image; and computing a three-dimensional point cloud by optimizing the rotation and translation of the light field and the disparity map. The first light field image may include a first plurality of subaperture images and the second light field image may include a second plurality of subaperture images.
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公开(公告)号:US20200231634A1
公开(公告)日:2020-07-23
申请号:US16632299
申请日:2018-07-20
Applicant: ShanghaiTech University
Inventor: Jia Liu , Biao Jiang
Abstract: Provided are chimeric polypeptides that include one or more zinc finger motifs fused to a therapeutic peptide such as botulinum neurotoxins (BoNTs). The zinc finger motif may be located at the C-terminal side of the BoNT and the chimeric polypeptide can optionally include two or more such zinc finger motifs. It said the disclosed chimeric polypeptides can be efficiently delivered to a subject transdermally.
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93.
公开(公告)号:US20250154146A1
公开(公告)日:2025-05-15
申请号:US18727048
申请日:2023-01-03
Applicant: ShanghaiTech University , Fudan University
Inventor: Xiaobao Yang , Biao Jiang , Wenfu Tan
IPC: C07D471/04 , A61K31/496 , A61K45/06 , A61P35/02 , C07D401/04
Abstract: The present disclosure provides protein degraders developed based on BCL-2 family protein lig and compounds, including compounds of Formula (I) or their salts, enantiomers, stereoisomers, solvates, prodrugs, or polymorphs, and their applications for treating diseases.
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公开(公告)号:US20250144223A1
公开(公告)日:2025-05-08
申请号:US18689031
申请日:2022-08-25
Inventor: Xiaobao Yang , Gaofeng Fan , Biao Jiang , Haixia Liu , Xiaotong Zhu , Renhong Sun
Abstract: The present disclosure provides compounds of Formula (I) or a salt, enantiomer, stereoisomer, solvate, isotopically enriched analog, prodrug, or polymorph thereof, and uses thereof. The present disclosure also provides pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, isotopically enriched analog, prodrug, or polymorph thereof, and uses thereof. The series of compounds designed and synthesized in the present disclosure can effectively prevent and/or treat diseases or disorders associated with NAMPT.
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公开(公告)号:US20250109139A1
公开(公告)日:2025-04-03
申请号:US18729910
申请日:2023-01-19
Applicant: SHANGHAITECH UNIVERSITY , CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES
Inventor: Jianjun CHENG , Sheng WANG , Ruiquan LIU , Jianzhong QI , Luyu FAN , Jing YU
IPC: C07D493/04 , A61K31/4355 , A61K31/437 , A61K31/4375 , A61K31/4985 , A61K31/53 , A61K31/538 , A61K31/541 , A61K31/55 , C07D487/04 , C07D519/00
Abstract: Disclosed are a tricyclic compound, and a preparation method therefor and the use thereof. The tricyclic compound has a structure as shown in formula I, and can be used for treating various mental diseases and neurodegenerative diseases such as schizophrenia, depression and Parkinson's disease.
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公开(公告)号:US12203077B2
公开(公告)日:2025-01-21
申请号:US16640337
申请日:2018-08-28
Applicant: ShanghaiTech University
Inventor: Jia Chen , Xingxu Huang , Li Yang , Bei Yang , Xiaosa Li , Ying Wang , Yajing Liu
Abstract: Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.
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公开(公告)号:US20240290059A1
公开(公告)日:2024-08-29
申请号:US18571748
申请日:2021-07-26
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Jiakai ZHANG , Jingyi YU , Lan XU
Abstract: A computer-implemented method of generating editable free-viewport videos is provided. A plurality of video of a scene from a plurality of views is obtained. The scene comprises includes an environment and one or more dynamic entities. A 3D bounding-box is generated for each dynamic entity in the scene. A computer device encodes a machine learning model including an environment layer and a dynamic entity layer for each dynamic entity in the scene. The environment layer represents a continuous function of space and time of the environment. The dynamic entity layer represents a continuous function of space and time of the dynamic entity. The dynamic entity layer includes a deformation module and a neural radiance module. The deformation module is configured to deform a spatial coordinate in accordance with a timestamp and a trained deformation weight. The neural radiance module is configured to derive a density value and a color.
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公开(公告)号:US20240289914A1
公开(公告)日:2024-08-29
申请号:US18537836
申请日:2023-12-13
Applicant: SHANGHAITECH UNIVERSITY
CPC classification number: G06T1/20 , G06F9/3851
Abstract: A graphics processing unit (GPU)-based logic rewriting acceleration method comprising parallelizing sub-procedures of And-Inverter Graph (AIG)-based logic rewriting. A recursive sub-procedure of the AIG-based logic rewriting is redesigned to be non-recursive, to provide sufficient parallelism for a GPU. In order to parallelize a replacement step on the GPU, the present disclosure uses a lock to ensure mutually exclusive access, which inevitably damages scalability of inter-node parallelism. In order to fully utilize the inter-node parallelism on a large scale, the present disclosure proposes a work scheduler that adds nodes with non-overlapping maximum fan-out-free cones (MFFCs) to a group, such that nodes in an MFFC can be deleted simultaneously without a conflict. In order to simultaneously create and delete a same node, the present disclosure also proposes a GPU-friendly graphical data structure to support these concurrent operations.
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公开(公告)号:US20240233796A1
公开(公告)日:2024-07-11
申请号:US18505128
申请日:2023-11-09
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Yuhao SHU , Hongtu ZHANG , Yajun HA
IPC: G11C11/402 , G11C11/408 , G11C11/4091 , G11C11/4096
CPC classification number: G11C11/4023 , G11C11/4087 , G11C11/4091 , G11C11/4096
Abstract: An energy-efficient memory for cryogenic computing is provided. The energy-efficient memory includes a plurality of memory banks, where each of the memory banks includes a cryogenic semi-static, dual-port, boost-free gain cell (CSDB-GC) macro module, a universal address decoder, and a different address decoder. The CSDB-GC macro module includes a plurality of columns of local blocks, and each of the local blocks includes a plurality of CSDB-GC memory cells. A final measurement result of a 16 Kb CSDB-eDRAM shows that the 16 Kb CSDB-eDRAM achieves data retention time (DRT) of 16.67 seconds, which is 2.6 times longer than DRT of a state-of-the-art cryogenic eDRAM at a temperature of 4.2 K, and achieves lower refresh power (0.11 pW/Kb). In addition, the 16 Kb CSDB-eDRAM also achieves shorter access time, namely, 710 ps (1.41 GHz). Compared with the state-of-the-art work, the 16 Kb CSDB-eDRAM has a lowest dynamic power consumption overhead, namely, 49.23 uW/Kb.
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100.
公开(公告)号:US20240230630A1
公开(公告)日:2024-07-11
申请号:US18559264
申请日:2022-04-13
Applicant: SHANGHAITECH UNIVERSITY
Inventor: Waichi SHUM , Baoli ZHANG , Huijuan SHI
CPC classification number: G01N33/5091 , H01J49/105 , G01N2800/367
Abstract: The present application provides a method for detecting infertile spermatozoa in a sample, the method comprising: detecting a concentration of at least one metal in the sample that falls outside of a predetermined range using single cell inductively coupled plasma mass spectrometry (sc-ICP-MS). It also provides a method for detecting infertile spermatozoa in a sample, which comprising: detecting a dynamic or kinetic parameter of a signal spike of at least one metal selected from the group of several metallic elements by sc-ICP-MS.
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