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214 条记录 (耗时 0.039 秒)

    Pharmaceutical combination of MEK inhibitor and B-RAF inhibitors
    91.
    发明授权
    Pharmaceutical combination of MEK inhibitor and B-RAF inhibitors 有权
    MEK抑制剂和B-RAF抑制剂的药物组合

    公开(公告)号：US08703781B2

    公开(公告)日：2014-04-22

    申请号：US13499779

    申请日：2010-10-15

    申请人： Melissa Dumble ,  Rakesh Kumar ,  Sylvie Laquerre ,  Peter Lebowitz

    发明人： Melissa Dumble ,  Rakesh Kumar ,  Sylvie Laquerre ,  Peter Lebowitz

    IPC分类号： A61K31/506 ,  A61K31/519 ,  A61K45/06

    CPC分类号： A61K31/519 ,  A61K31/506 ,  A61K45/06 ,  A61K2300/00

    摘要： A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, with a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophen-}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf is beneficial, eg. cancer.

    摘要翻译： 包含MEK抑制剂N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基）6,8-二甲基-2,4,7-三氧代-3,4,6 ，7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂合物与B-Raf抑制剂，特别是N- {3- [5- （2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基] -2-氟苯基} -2,6-二氟苯磺酰胺或其药学上可接受的盐，药物 包含其的组合物和使用这些组合和组合物治疗MEK和/或B-Raf的抑制作用有利的条件的方法，例如， 癌症。

    Real-time action detection and classification
    92.
    发明授权
    Real-time action detection and classification 有权
    实时动作检测与分类

    公开(公告)号：US08634638B2

    公开(公告)日：2014-01-21

    申请号：US12488911

    申请日：2009-06-22

    申请人： Feng Han ,  Hui Cheng ,  Jiangjian Xiao ,  Harpreet Singh Sawhney ,  Sang-Hack Jung ,  Rakesh Kumar ,  Yanlin Guo

    发明人： Feng Han ,  Hui Cheng ,  Jiangjian Xiao ,  Harpreet Singh Sawhney ,  Sang-Hack Jung ,  Rakesh Kumar ,  Yanlin Guo

    IPC分类号： G06K9/62

    CPC分类号： G06K9/00342

    摘要： The present invention relates to a method and system for creating a strong classifier based on motion patterns wherein the strong classifier may be used to determine an action being performed by a body in motion. When creating the strong classifier, action classification is performed by measuring similarities between features within motion patterns. Embodiments of the present invention may utilize candidate part-based action sets and training samples to train one or more weak classifiers that are then used to create a strong classifier.

    摘要翻译： 本发明涉及一种用于基于运动模式创建强分类器的方法和系统，其中强分类器可用于确定由运动中的身体执行的动作。 当创建强分类器时，通过测量运动模式中的特征之间的相似度来执行动作分类。 本发明的实施例可以利用基于候选部分的动作集和训练样本来训练一个或多个弱分类器，然后将其用于创建强分类器。

    COMBINATION
    93.
    发明申请
    COMBINATION 审中-公开

    公开(公告)号：US20130237554A1

    公开(公告)日：2013-09-12

    申请号：US13699103

    申请日：2011-05-25

    申请人： Rakesh Kumar

    发明人： Rakesh Kumar

    IPC分类号： A61K31/506 ,  A61K31/4155

    CPC分类号： A61K31/635 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/4155 ,  A61K31/506 ,  C07D403/12 ,  C07D409/04 ,  A61K2300/00

    摘要： The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

    COMBINATION
    95.
    发明申请
    COMBINATION 审中-公开

    公开(公告)号：US20130072507A1

    公开(公告)日：2013-03-21

    申请号：US13698847

    申请日：2011-05-19

    申请人： Tona M. Gilmer ,  Rakesh Kumar

    发明人： Tona M. Gilmer ,  Rakesh Kumar

    IPC分类号： A61K31/517 ,  A61P35/02 ,  A61P35/00

    CPC分类号： A61K31/517 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K31/4155 ,  A61K31/4375 ,  A61K2300/00

    摘要： The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine, or a pharmaceutically acceptable hydrate and/or salt thereof, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

    System and method for detection of multi-view/multi-pose objects
    97.
    发明授权
    System and method for detection of multi-view/multi-pose objects 有权
    用于检测多视点/多姿态对象的系统和方法

    公开(公告)号：US08391592B2

    公开(公告)日：2013-03-05

    申请号：US13134885

    申请日：2011-06-20

    申请人： Feng Han ,  Ying Shan ,  Harpreet Singh Sawhney ,  Rakesh Kumar

    发明人： Feng Han ,  Ying Shan ,  Harpreet Singh Sawhney ,  Rakesh Kumar

    IPC分类号： G06K9/62

    CPC分类号： G06K9/6256

    摘要： The present invention provides a computer implemented process for detecting multi-view multi-pose objects. The process comprises training of a classifier for each intra-class exemplar, training of a strong classifier and combining the individual exemplar-based classifiers with a single objective function. This function is optimized using the two nested AdaBoost loops. The first loop is the outer loop that selects discriminative candidate exemplars. The second loop, the inner loop selects the discriminative candidate features on the selected exemplars to compute all weak classifiers for a specific position such as a view/pose. Then all the computed weak classifiers are automatically combined into a final classifier (strong classifier) which is the object to be detected.

    摘要翻译： 本发明提供了一种用于检测多视点多姿态对象的计算机实现过程。 该过程包括针对每个类内样本的分类器的训练，强分类器的训练和将单个基于样本的分类器与单个目标函数组合。 使用两个嵌套的AdaBoost循环来优化此功能。 第一个循环是选择区分候选样本的外循环。 第二个循环，内循环选择所选样本上的鉴别候选特征，以计算特定位置（例如视图/姿态）的所有弱分类器。 然后将所有计算的弱分类器自动组合成最终分类器（强分类器），该分类器是要检测的对象。

    Managing Power Consumption In A Multi-Core Processor
    99.
    发明申请
    Managing Power Consumption In A Multi-Core Processor 有权
    管理多核处理器中的功耗

    公开(公告)号：US20120254643A1

    公开(公告)日：2012-10-04

    申请号：US13422476

    申请日：2012-03-16

    申请人： Eric Fetzer ,  Reid J. Reidlinger ,  Don Soltis ,  William J. Bowhill ,  Satish Shrimali ,  Krishnakanth Sistla ,  Efraim Rotem ,  Rakesh Kumar ,  Vivek Garg ,  Alon Naveh ,  Lokesh Sharma

    发明人： Eric Fetzer ,  Reid J. Reidlinger ,  Don Soltis ,  William J. Bowhill ,  Satish Shrimali ,  Krishnakanth Sistla ,  Efraim Rotem ,  Rakesh Kumar ,  Vivek Garg ,  Alon Naveh ,  Lokesh Sharma

    IPC分类号： G06F1/32

    CPC分类号： G06F1/3296 ,  G06F1/324 ,  Y02D10/126 ,  Y02D10/172 ,  Y02D50/20

    摘要： A processor may include a core and an uncore area. The power consumed by the core area may be controlled by controlling the Cdyn of the processor such that the Cdyn is within an allowable Cdyn value irrespective of the application being processed by the core area. The power management technique includes measuring digital activity factor (DAF), monitoring architectural and data activity levels, and controlling power consumption by throttling the instructions based on the activity levels. As a result of throttling the instructions, throttling may be implemented in 3rd droop and thermal design point (TDP). Also, the idle power consumed by the uncore area while the core area is in deep power saving states may be reduced by varying the reference voltage VR and the VP provided to the uncore area. As a result, the idle power consumed by the uncore area may be reduced.

    摘要翻译： 处理器可以包括核心和无孔区域。 可以通过控制处理器的Cdyn来控制核心区域消耗的功率，使得Cdyn处于可允许的Cdyn值内，而不管应用程序是否被核心区域处理。 电源管理技术包括测量数字活动因素（DAF），监控架构和数据活动级别，以及通过基于活动级别来限制指令来控制功耗。 作为节流指令的结果，节流可以在第3垂直和热设计点（TDP）中实现。 此外，通过改变提供给无孔区域的参考电压VR和VP，可以减少核心区域处于深功率节省状态时由无孔区域消耗的空闲功率。 结果，可以减少由无孔区域消耗的空闲功率。

    Pharmaceutical Combination of MEK Inhibitor and B-RAF Inhibitors
    100.
    发明申请
    Pharmaceutical Combination of MEK Inhibitor and B-RAF Inhibitors 有权
    MEK抑制剂和B-RAF抑制剂的药物组合

    公开(公告)号：US20120196879A1

    公开(公告)日：2012-08-02

    申请号：US13499779

    申请日：2010-10-15

    申请人： Melissa Dumble ,  Rakesh Kumar ,  Sylvie Laquerre ,  Peter Lebowitz

    发明人： Melissa Dumble ,  Rakesh Kumar ,  Sylvie Laquerre ,  Peter Lebowitz

    IPC分类号： A61K31/519 ,  A61P35/02 ,  A61P35/00

    CPC分类号： A61K31/519 ,  A61K31/506 ,  A61K45/06 ,  A61K2300/00

    摘要： A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, with a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophen-}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf is beneficial, eg. cancer.

    摘要翻译： 包含MEK抑制剂N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基）6,8-二甲基-2,4,7-三氧代-3,4,6 ，7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂合物与B-Raf抑制剂，特别是N- {3- [5- （2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基] -2-氟苯基} -2,6-二氟苯磺酰胺或其药学上可接受的盐，药物 包含其的组合物和使用这些组合和组合物治疗MEK和/或B-Raf的抑制作用有利的条件的方法，例如， 癌症。