摘要:
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要:
Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of identical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.
摘要:
Systems and methods are described for multicarrier orthogonal spread-spectrum (MOSS) data communication. A method includes individually spread-spectrum modulating at least two of a set of orthogonal frequency division multiplexed carriers, wherein the resulting individually spread-spectrum modulated at least two of a set of orthogonal frequency division multiplexed carriers are substantially mutually orthogonal with respect to both frequency division multiplexing and spread-spectrum modulation.
摘要:
A reclosable lid (10) for a container holding a flowable substance has a cover (12) having an opening (28) and a moveable element (850) connected to the cover (12). The moveable element (850) is moveable between at least one open position, wherein the flowable substance may flow through the opening, and at least one closed position, wherein the opening is obstructed. In some embodiments, the lid (10) may include an overlay (250) moveable between at least one open position and at least one closed position.
摘要:
Systems and methods are described for hybrid spread spectrum radio systems. A method, includes receiving a hybrid spread spectrum signal including: fast frequency hopping demodulating and direct sequence demodulating a direct sequence spread spectrum signal, wherein multiple frequency hops occur within a single data-bit time and each bit is represented by chip transmissions at multiple frequencies
摘要:
A composite box structure mounted on and attached to a railway car underframe to form a temperature controlled railway car. The composite box structure defined in part by an exterior metal surface, interior side stakes and at least one layer of fiber reinforced material attached to the side stakes. Insulating material may be disposed between the side stakes, the exterior metal surface and the at least one fiber reinforced layer of fiber reinforced material. The insulating materials provide resistance to heat transfer between the interior and the exterior of the composite box structure. A primary floor assembly and a secondary floor assembly may be mounted on the railway car underframe.
摘要:
A method and apparatus for a low noise low jitter signal source is provided. A Voltage Controlled Oscillator (VCO) is configured as part of a phase locked Loop (PLL) with a reference clock, a loop filter and a method of offsetting the Tune Voltage input to the Voltage Controlled Oscillator (VCO) to achieve low phase noise. A method and apparatus for precisely controlled jitter injection into a high speed data or clock signals is provided. Using IQ modulation techniques comprising an IQ modulator, by synchronously controlling the IQ modulator inputs precisely controlled phase shift for jitter injection are produced. This can also be used with the low noise low jitter signal source described herein.
摘要:
Systems and methods are described for use in user interactive systems (UIS) so that multiple disparate applications can cooperate to provide broad functionality to users. These systems and methods allow applications to advertise their ability to handle specific functions. This allows applications developed independently to co-exist within the same call session and provide a seamless user experience. A system framework controls the UIS's primary navigational menus, which are automatically updated when new applications are plugged in to the framework. This allows users (assuming they have the proper permissions) to access new applications as soon as they are added, without requiring programmers to manually re-design menus.
摘要:
A multi-channel fiber optic rotary joint (FORJ) includes an external housing, a stationary collimator array, a rotating collimator array, an all-reflective de-rotating prism and a gear ratio. The external housing contains an internal cavity having a longitudinal rotation axis. The stationary collimator array is affixed to the external housing approximate a first end of the internal cavity. The rotating collimator array is rotatably attached to the external housing approximate a second end of the cavity. The second end of the cavity is opposite the first end of the cavity. The rotating collimator array is configured to rotate about the rotation axis. The de-rotating prism is located along the rotation axis within the internal cavity between the stationary collimator array and the rotating collimator array. The prism is retained in a prism housing, which is rotatably attached to the external housing and the prism housing is configured to rotate about the rotation axis.