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204 条记录 (耗时 0.024 秒)

    Salix extract, its use and formulations containing it
    91.
    发明申请
    Salix extract, its use and formulations containing it 审中-公开
    柳叶提取物，其使用和配方含有它

    公开(公告)号：US20090143315A1

    公开(公告)日：2009-06-04

    申请号：US11988586

    申请日：2006-06-14

    申请人： Ezio Bombardelli ,  Andrea Giori ,  Alessandro Anelli

    发明人： Ezio Bombardelli ,  Andrea Giori ,  Alessandro Anelli

    IPC分类号： A61K31/7034 ,  A61P19/02

    CPC分类号： A61K36/76 ,  A61K9/4858

    摘要： The present invention relates to an extract of Salix spp obtainable by fractioning on a resin and to the process for its preparation.The extract of the invention is characterized by an high content in salicin derivatives, reduced content in high molecular tannins and a content in proanthocyanidins sufficient to inhibit some tissue metal proteases. The product is formulated in oils rich in ω-3 and ω-6 acids which provide a better absorption of the extract active principles, also increasing synergetically their action.

    摘要翻译： 本发明涉及通过在树脂上分级得到的柳叶螨提取物及其制备方法。 本发明的提取物的特征在于水杨苷衍生物含量高，高分子单宁含量降低，原花色素含量足以抑制一些组织金属蛋白酶。 该产品配制成富含ω-3和ω-6酸的油，其提供了对提取物活性成分的更好吸收，同时也增加了它们的作用。

    N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM
    94.
    发明申请
    N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM 有权
    N-脱乙酰基胆碱衍生物，其使用和含有它们的药物制剂

    公开(公告)号：US20080269292A1

    公开(公告)日：2008-10-30

    申请号：US12142522

    申请日：2008-06-19

    申请人： Ezio Bombardelli ,  Gabriele Fontana

    发明人： Ezio Bombardelli ,  Gabriele Fontana

    IPC分类号： A61K31/44 ,  A61K31/17 ,  A61K31/166 ,  A61P35/00 ,  A61K31/445 ,  A61K31/165

    CPC分类号： C07D213/82 ,  C07C323/30 ,  C07C323/41 ,  C07C323/44 ,  C07C2603/34

    摘要： Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antinflammatory, antiarthritic and antiviral activity.

    摘要翻译： 公开了一系列式I的N-脱乙酰基秋水仙碱衍生物，其中：连接体是二价直链或支链C 1 -C 8烷基残基C 3 C 8 -C 8环烷基，亚苯基或杂环C 4 -C 6环; 可以相同或不同的G 1和N 2和G 2结是-CO - ， - CONH - ， - NR 2 - 其中R 2是氢或直链C 1 -C 4烷基残基的基团，或者R 1' -linker-G 基团是-CO-基团。 式I的化合物具有抗增殖，抗炎，抗关节炎和抗病毒活性。

    Process for the preparation of taxanes from 10-deacetylbaccatin III
    97.
    再颁专利
    Process for the preparation of taxanes from 10-deacetylbaccatin III 有权
    10-脱乙酰基浆果赤霉素III制备紫杉烷类的方法

    公开(公告)号：USRE40120E1

    公开(公告)日：2008-02-26

    申请号：US11025830

    申请日：2000-02-23

    申请人： Ezio Bombardelli

    发明人： Ezio Bombardelli

    IPC分类号： C07D305/14

    CPC分类号： C07D413/12 ,  C07D305/14 ,  Y02P20/55

    摘要： A process for the preparation of taxane derivatives by reacting 10-deacetylbaccatin III protected at the 7-and 1-positions with trichloroacetyl groups with a compound of formula and subsequent removal of the protective groups and hydrolysis of the oxazolidine ring.

    摘要翻译： 通过将在7-位和1-位保护的10-脱乙酰基浆果赤霉素III与三氯乙酰基与下式化合物反应制备紫杉烷衍生物的方法，随后除去保护基团和恶唑烷环的水解。

    Oral compositions for the treatment of cellulite
    98.
    发明申请
    Oral compositions for the treatment of cellulite 有权
    用于治疗脂肪团的口服组合物

    公开(公告)号：US20060292249A1

    公开(公告)日：2006-12-28

    申请号：US10570943

    申请日：2004-09-10

    申请人： Ezio Bombardelli

    发明人： Ezio Bombardelli

    IPC分类号： A61K36/87 ,  A61K36/28 ,  A61K36/16

    CPC分类号： A61K36/16 ,  A61K36/23 ,  A61K36/87 ,  A61K2300/00

    摘要： The present invention relates to oral pharmaceutical and cosmetic compositions for the treatment of cellulite containing Vitis vinifera extracts, Centella asiatica triterpenes and dimeric Ginkgo biloba flavonoids, in the free form or complexed with phospholipids.

    摘要翻译： 本发明涉及用于治疗含有葡萄酒提取物，积雪草三叶萜和二聚银杏叶黄酮的脂肪团的口服药物和化妆品组合物，其为游离形式或与磷脂络合。