公开(公告)号：US20080064915A1

公开(公告)日：2008-03-13

申请号：US11981063

申请日：2007-10-31

申请人： Paul Lubock

发明人： Paul Lubock

IPC分类号： A61N5/00 ,  A61M1/00

CPC分类号： A61N5/1015 ,  A61B2017/22048 ,  A61B2017/22051

摘要： Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.

摘要翻译： 提供了设备和方法，用于在靠近体腔的组织递送治疗装置的地方施加真空，有效地吸引靠近这种装置的邻近组织并增强对组织的治疗。 体腔包括自然体腔和去除组织如癌组织后残留的空腔。 装置可以包括具有充气导管的内气囊组件。 具有流体可渗透护套壁的护套组件可以封闭内部气囊组件。 施加到护套和内囊之间的空间的真空用于使组织与装置接触，提高治疗效果。 还提供了用这种装置和系统处理组织的方法。 治疗可以包括提供用于放射治疗的放射性物质，提供用于化疗的化学治疗材料，提供热治疗及其组合。 系统可以包括本发明的装置和真空源。

公开(公告)号：US07322940B2

公开(公告)日：2008-01-29

申请号：US10790661

申请日：2004-03-01

申请人： Fred H. Burbank ,  Michael L. Jones ,  Paul Lubock

发明人： Fred H. Burbank ,  Michael L. Jones ,  Paul Lubock

IPC分类号： A61B10/00 ,  A61B18/18

CPC分类号： A61B10/0266 ,  A61B10/02 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/14 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2090/3908

摘要： An instrument assembly and method are described for isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required. In particular, the instrument assembly has a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along a distal portion of the shaft. The cutting element is actuatable between a retracted position within an electrically insulating recess and a radially extended position and is rotatable about its axis in the radially extended position to isolate a desire tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen.

摘要翻译： 描述了用于分离患者身体组织中的靶病变的器械组件和方法，导致当其被去除以用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。 这种方法有利地经常导致仅用单一经皮手术诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术。 特别地，仪器组件具有适于进入患者身体的远端，纵向轴和沿着轴的远端部分设置的切割元件。 切割元件可以在电绝缘凹槽中的缩回位置和径向延伸的位置之间致动，并且可以在其径向延伸的位置绕其轴线旋转，以通过围绕组织样本限定周边边缘来隔离期望的组织样本与周围组织。

公开(公告)号：US07214178B2

公开(公告)日：2007-05-08

申请号：US11105856

申请日：2005-04-14

申请人： Paul Lubock

发明人： Paul Lubock

IPC分类号： A61N5/00

CPC分类号： A61N5/1015 ,  A61B2017/22048 ,  A61B2017/22051

摘要： Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.

摘要翻译： 提供了设备和方法，用于在靠近体腔的组织递送治疗装置的地方施加真空，有效地吸引靠近这种装置的邻近组织并增强对组织的治疗。 体腔包括自然体腔和去除组织如癌组织后残留的空腔。 装置可以包括具有充气导管的内气囊组件。 具有流体可渗透护套壁的护套组件可以封闭内部气囊组件。 施加到护套和内囊之间的空间的真空用于使组织与装置接触，提高治疗效果。 还提供了用这种装置和系统处理组织的方法。 治疗可以包括提供用于放射治疗的放射性物质，提供用于化疗的化学治疗材料，提供热治疗及其组合。 系统可以包括本发明的装置和真空源。

公开(公告)号：US06958044B2

公开(公告)日：2005-10-25

申请号：US10004987

申请日：2001-12-04

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

IPC分类号： A61B10/02 ,  A61B10/00 ,  A61B17/00 ,  A61B17/22 ,  A61B17/32 ,  A61B17/34 ,  A61B18/12 ,  A61B18/14 ,  A61B19/00 ,  A61F2/82

CPC分类号： A61B10/04 ,  A61B10/02 ,  A61B10/0241 ,  A61B10/0266 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/12 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/320064 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2019/5487 ,  A61B2019/5491 ,  A61B2090/3908 ,  A61B2090/3991

摘要： Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

公开(公告)号：US06955641B2

公开(公告)日：2005-10-18

申请号：US10849410

申请日：2004-05-19

申请人： Paul Lubock

发明人： Paul Lubock

IPC分类号： A61F2/958 ,  A61N5/10 ,  A61N5/00

CPC分类号： A61N5/1015 ,  A61B2017/22048 ,  A61B2017/22051

摘要： Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.

公开(公告)号：US20050119562A1

公开(公告)日：2005-06-02

申请号：US10976138

申请日：2004-10-27

申请人： Michael Jones ,  Paul Lubock ,  Lloyd Malchow

发明人： Michael Jones ,  Paul Lubock ,  Lloyd Malchow

IPC分类号： A61B17/00 ,  A61B19/00 ,  A61B5/05

CPC分类号： A61M37/0069 ,  A61B17/0057 ,  A61B90/39 ,  A61B2017/00831 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3987

摘要： The invention is directed to an intracorporeal fibrous marker formed of a fibrous pad or mat with strands of synthetic polymeric material such as polyglycolic acid and delivery devices and methods of using such devices. The fibrous pad or mat has a bulk density of at least 10, preferably about 30 to about 100 mg/cc and typically about 40 mg/cc. The fibrous marker has an effective in vivo lifespan of at least three weeks.

摘要翻译： 本发明涉及由具有合成聚合物材料如聚乙醇酸和递送装置的纤维垫或垫的纤维垫或垫形成的体内纤维标记物和使用这种装置的方法。 纤维垫或垫的堆积密度为至少10，优选约30至约100mg / cc，通常为约40mg / cc。 纤维标记物具有至少三周的有效的体内寿命。

公开(公告)号：US06862470B2

公开(公告)日：2005-03-01

申请号：US10124757

申请日：2002-04-16

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

IPC分类号： A61B6/00 ,  A61B6/12 ,  A61B8/08 ,  A61B8/12 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B19/00 ,  A61K49/00 ,  A61K49/04 ,  A61K49/22

CPC分类号： A61B8/481 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61K49/222 ,  A61M37/0069

摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

摘要翻译： 本发明提供用于在有限时间内标记活检部位的材料，装置和方法。 活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。 粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。 用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。 系统可以包括含有粉末的管和含有无菌盐水的注射器。 管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

公开(公告)号：US06676658B2

公开(公告)日：2004-01-13

申请号：US09884349

申请日：2001-06-18

申请人： Fred H. Burbank ,  Paul Lubock

发明人： Fred H. Burbank ,  Paul Lubock

IPC分类号： A61B1818

CPC分类号： A61B10/0266 ,  A61B10/0041 ,  A61B10/02 ,  A61B10/0233 ,  A61B17/00234 ,  A61B17/00491 ,  A61B17/221 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/0206 ,  A61B18/06 ,  A61B18/14 ,  A61B18/148 ,  A61B18/1482 ,  A61B18/1487 ,  A61B18/1492 ,  A61B18/20 ,  A61B90/37 ,  A61B2010/0208 ,  A61B2017/00287 ,  A61B2017/2212 ,  A61B2017/320733 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/144 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2018/1861 ,  A61B2090/3908 ,  A61N5/1007 ,  A61N5/1027

摘要： A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating tool and a tissue specimen damager. The tissue specimen isolating tool isolates the tissue specimen from the surrounding tissue. The tissue specimen damager damages the tissue, with a possible end result being necrosis. The severing tool may have a cutting member that is extendable to an outwardly radially bowed position about device. The tissue specimen is isolated by rotating the cutting member about the tissue specimen. The cutting member may be functionally connected to a cutting member radio frequency generation source. The tissue specimen damager may damage the tissue specimen using ionizing radiation, cutting devices, thermal treatment devices, chemical treatment devices, or sealing an outer boundary of the tissue specimen.

公开(公告)号：US06638234B2

公开(公告)日：2003-10-28

申请号：US09727112

申请日：2000-11-29

申请人： Fred H. Burbank ,  Paul Lubock

发明人： Fred H. Burbank ,  Paul Lubock

IPC分类号： A61B1000

CPC分类号： A61B10/0266 ,  A61B6/4258 ,  A61B10/02 ,  A61B17/00491 ,  A61B18/1477 ,  A61B18/1482 ,  A61B18/1487 ,  A61B18/1815 ,  A61B90/39 ,  A61B2010/0208 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00273 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00916 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/378 ,  A61B2090/3904 ,  A61B2090/3908 ,  A61B2090/392

摘要： A method and apparatus for locating and accessing a patient's sentinel lymph nodes which are associated with a lesion site of the patient. A radiopharmaceutical is injected at or near a lesion site within a patient's body. The migration of the radiopharmaceutical and accumulation of the radiopharmaceutical in a sentinel node of the patient is monitored with a gamma camera or radiation energy detector from outside the patient's body. The sentinel node can then be accessed with a cannula having an RF energy electrode on the distal end of the cannula which is activated during insertion of the cannula. Once the distal end of the cannula is positioned adjacent the sentinel node, an anchor device is inserted through the cannula. The distal end of the anchor device is then positioned in the sentinel node and secured to the sentinel node to be used as a locator for subsequent procedures.

摘要翻译： 一种用于定位和访问与患者的病变部位相关联的患者前哨淋巴结的方法和装置。 在患者体内的病变部位处或附近注射放射性药物。 放射性药物的迁移和放射性药物的积聚在患者的前哨淋巴结中用伽马照相机或辐射能量检测器从患者身体外部监测。 然后可以使用在插管的远端处具有RF能量电极的插管来访问前哨节点，其在插管期间被激活。 一旦套管的远端定位成邻近前哨节点，锚定装置就插入插管中。 然后将锚装置的远端定位在前哨节点中并固定到前哨节点，以用作后续步骤的定位器。

公开(公告)号：US06261241B1

公开(公告)日：2001-07-17

申请号：US09159467

申请日：1998-09-23

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

IPC分类号： A61B1000

CPC分类号： A61B10/0266 ,  A61B10/02 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/14 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B2010/0208 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2090/3908

摘要： An electrosurgical biopsy device includes a stylet and a cannula movably mounted on a base. The stylet has a shaft with a head at its distal end and a stylet ablation element extending distally from the head. The stylet shaft is disposed through the cannula for axial translation therein between withdrawn and extended positions. The cannula has an opening at its distal end and a cannula ablation element adjacent the opening. Both ablation elements are activatable with energy that ablates adjacent tissue. A translation mechanism controllably moves (a) the stylet between the withdrawn and extended positions and (b) the cannula between a proximal position and a distal position relative to the base. In use, with the stylet in the withdrawn position against the distal end of the cannula, and with the stylet ablation element activated, the stylet and the cannula are pushed through the skin and the underlying tissue until the stylet head is adjacent a targeted tissue mass. Next, the stylet is extended distally from the distal end of the cannula so that its head penetrates the tissue mass. The cannula ablation element is then activated, and the cannula is pushed through the tissue mass toward the stylet head, thereby cutting a “core” through the tissue mass that is captured as a tissue specimen within the distal end of the cannula. The cannula and the stylet are then removed from the patient's body.