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310 条记录 (耗时 0.103 秒)

    Mammary transforming protein
    91.
    发明授权
    Mammary transforming protein 失效
    乳腺转化蛋白

    公开(公告)号：US06482922B2

    公开(公告)日：2002-11-19

    申请号：US09263811

    申请日：1999-03-08

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

    IPC分类号： C07K100

    CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026 ,  C12Q1/6886 ,  C12Q2600/136

    摘要： A human mammary transforming protein and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for inhibiting such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种多肽的人类乳腺转化蛋白和DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了抑制这种多肽以预防和/或治疗瘤形成的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

    Antibody to human endokine alpha and methods of use
    92.
    发明授权
    Antibody to human endokine alpha and methods of use 失效
    人内因素α抗体

    公开(公告)号：US06406867B1

    公开(公告)日：2002-06-18

    申请号：US09513584

    申请日：2000-02-25

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： C07K1622

    CPC分类号： C07K14/7151 ,  A61K38/00 ,  C07K14/5255 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S514/885

    摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and antibody fragments which specifically bind the polypeptides of the invention are also provided, as well as methods for detecting the polypeptides of the invention using said antibodies and antibody fragments. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

    摘要翻译： 本发明涉及细胞因子的肿瘤坏死因子（TNF）家族的新成员。 特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。 还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了特异性结合本发明多肽的抗体和抗体片段，以及使用所述抗体和抗体片段检测本发明的多肽的方法。 还提供了关于TNF家族相关疾病的诊断和治疗方法。

    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA
    95.
    发明申请
    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA 审中-公开
    使用抗体治疗中耳炎的方法

    公开(公告)号：US20100330073A1

    公开(公告)日：2010-12-30

    申请号：US12870394

    申请日：2010-08-27

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    IPC分类号： A61K39/395 ,  C12N5/02 ,  A61P35/00 ,  C07K16/18

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA
    98.
    发明申请
    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA 有权
    使用抗体治疗中耳炎的方法

    公开(公告)号：US20090068201A1

    公开(公告)日：2009-03-12

    申请号：US12170333

    申请日：2008-07-09

    申请人： GUO-LIANG YU ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    发明人： GUO-LIANG YU ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： A61K39/395 ,  A61K38/00 ,  C12N5/06 ,  A61P31/00

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Death domain containing receptor 5
    99.
    发明申请
    Death domain containing receptor 5 审中-公开
    含有受体5的死亡域

    公开(公告)号：US20080248046A1

    公开(公告)日：2008-10-09

    申请号：US12010106

    申请日：2008-01-18

    申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： A61K39/395 ,  C12N5/06 ,  A61P35/00 ,  A61P31/12

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K16/2878 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2319/30

    摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。 本发明还涉及使用DR5特异性抗体（其可以是DR5活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。