公开(公告)号：US08948770B2

公开(公告)日：2015-02-03

申请号：US14234873

申请日：2012-01-12

Applicant: Jinling Du ,  Ting Zhou ,  Jing Xu ,  Zhenhong Li ,  Haifeng Wang

Inventor： Jinling Du ,  Ting Zhou ,  Jing Xu ,  Zhenhong Li ,  Haifeng Wang

IPC: H04W72/00 ,  H04W74/08

CPC classification number: H04W74/0833 ,  H04W36/00 ,  H04W36/30 ,  H04W76/23 ,  H04W84/08 ,  H04W88/04

Abstract: The present invention discloses a cluster head assisted method for converting a user terminal from device-to-device (D2D) communication to cellular communication. When quality of a D2D link between a user terminal and a cluster head is lower than a predetermined threshold, if the user terminal has to leave the cluster but still expects to continue an original the service, the user terminal performs cell search and random access, and establishes a radio resource control (RRC) connection with a target base station of a cellular network. Switching from D2D communication to cellular communication is implemented with the assistance of the cluster head, and a communication manner after the switching is provided. The present invention implements mobile switching from D2D communication in distributed cluster communication to cellular communication, which can reduce route search delay and save wireless resources.

Abstract translation: 本发明公开了一种用于将用户终端从设备到设备（D2D）通信转换为蜂窝通信的簇头辅助方法。 当用户终端和集群头之间的D2D链路的质量低于预定阈值时，如果用户终端必须离开集群但仍然期望继续原始服务，则用户终端执行小区搜索和随机接入， 并建立与蜂窝网络的目标基站的无线资源控制（RRC）连接。 在D2D通信到蜂窝通信的切换的同时，在簇头的协助下进行切换，提供切换后的通信方式。 本发明实现从分布式集群通信中的D2D通信到蜂窝通信的移动交换，可以减少路由搜索延迟并节省无线资源。

公开(公告)号：US20140357274A1

公开(公告)日：2014-12-04

申请号：US14372508

申请日：2012-01-20

Applicant: Yong Teng ,  Kari Veikko Horneman ,  Bin Chen ,  Jiang Wang ,  Jing Xu

Inventor： Yong Teng ,  Kari Veikko Horneman ,  Bin Chen ,  Jiang Wang ,  Jing Xu

IPC: H04W36/00

CPC classification number: H04W36/0094 ,  H04W36/0058 ,  H04W36/00835 ,  H04W36/32

Abstract: A technique includes: comparing (a) measurements made at the first access node of transmissions made by a plurality of other access nodes against (b) measurements made at the communication device of transmissions made by said plurality of other access nodes; and deciding whether or not to select said first access node as a handover candidate for said communication device based at least partly on the result of said comparison.

Abstract translation: 一种技术包括：比较（a）在多个其他接入节点进行的传输的第一接入节点处进行的测量与（b）在通信设备处对由所述多个其他接入节点进行的传输所做的测量进行比较; 以及至少部分地基于所述比较的结果来决定是否选择所述第一接入节点作为所述通信设备的切换候选。

公开(公告)号：US20140357273A1

公开(公告)日：2014-12-04

申请号：US14371859

申请日：2012-01-20

Applicant: Yong Teng ,  Kari Veikko Horneman ,  Tao Peng ,  Jiang Wang ,  Jing Xu

Inventor： Yong Teng ,  Kari Veikko Horneman ,  Tao Peng ,  Jiang Wang ,  Jing Xu

IPC: H04W8/02 ,  H04W36/32

CPC classification number: H04W8/02 ,  H04W36/00837 ,  H04W36/32 ,  H04W64/006

Abstract: The disclosure relates to generation of mobility information. A mobile device can determine, based on measurements, at least one parameter relating to its movement relative to a cell. A weighting of a counter output for use in estimation of a mobility state of the mobile device is determined. The determining includes comparison of the at least one parameter to at least one threshold. Information about the weighting can be provided by a network element. When the network element obtains the weighted estimation it can take it into account in mobility control of the mobile device.

Abstract translation: 本公开涉及移动信息的生成。 移动设备可以基于测量来确定与其相对于小区的移动相关的至少一个参数。 确定用于估计移动设备的移动性状态的计数器输出的加权。 确定包括至少一个参数与至少一个阈值的比较。 关于加权的信息可以由网络元件提供。 当网元获得加权估计时，可以考虑移动设备的移动性控制。

公开(公告)号：US08840768B2

公开(公告)日：2014-09-23

申请号：US13562410

申请日：2012-07-31

Applicant: Xiaoya Liu ,  Yiqun Yang ,  Chenglin Yi ,  Jing Luo ,  Haiqiang Wu ,  Sisi Jiang ,  Baoqing Wang ,  Jinqiang Jiang ,  Ren Liu ,  Shengwen Zhang ,  Jing Xu

Inventor： Xiaoya Liu ,  Yiqun Yang ,  Chenglin Yi ,  Jing Luo ,  Haiqiang Wu ,  Sisi Jiang ,  Baoqing Wang ,  Jinqiang Jiang ,  Ren Liu ,  Shengwen Zhang ,  Jing Xu

IPC: C25D13/00 ,  G01N33/543 ,  G01N27/327

CPC classification number: G01N33/5438 ,  G01N27/3275

Abstract: A preparation method for molecular recognition sensor by electrodeposition is provided. The preparation method is as following: forming molecularly imprinted polymeric micelles by self-assembly of ionic type photosensitive copolymers; forming a film on the surface of an electrode by electrodepositing the molecularly imprinted polymeric micelles at a constant potential; crosslinking the electrodeposited micellar film via ultraviolet light irradiation; extracting the template molecules from the crosslinked film to obtain electrode modified by the molecularly imprinted polymeric micellar film; and connecting the modified electrode with a sensor device and a computer to construct a molecular recognition sensing system capable of specifically detecting the template molecules.

Abstract translation: 提供了通过电沉积分子识别传感器的制备方法。 制备方法如下：通过离子型光敏共聚物的自组装形成分子印迹的聚合胶束; 通过以恒定电位沉积分子印迹的聚合物胶束在电极的表面上形成膜; 通过紫外光照射交联电沉积胶束膜; 从交联膜中提取模板分子，得到由分子印迹聚合物胶束膜改性的电极; 并且将修改的电极与传感器装置和计算机连接以构建能够特异性检测模板分子的分子识别感测系统。

公开(公告)号：US20140081012A1

公开(公告)日：2014-03-20

申请号：US13985491

申请日：2012-02-15

Applicant: Joseph M. DeSimone ,  Mary Napier ,  Jin Wang ,  Jing Xu ,  Shaomin Tian ,  Stuart Dunn

Inventor： Joseph M. DeSimone ,  Mary Napier ,  Jin Wang ,  Jing Xu ,  Shaomin Tian ,  Stuart Dunn

IPC: C07D207/46 ,  C12N15/113

CPC classification number: C07D207/46 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/08 ,  A61K47/54 ,  A61K47/543 ,  A61K47/60 ,  A61K47/6929 ,  C07D233/90 ,  C07D403/12 ,  C12N15/113

Abstract: Pharmaceutical, chemical and biological agents containing a reversible disulfide linker are described. These agents can also be covalently bound or contained in delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain an agent having a reversible disulfide linker and to vehicles that are covalently linked to the agent containing a reversible disulfide linker. The modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting while the reversibility of the linker can leave the agent to which it is attached free from residual chemical groups after being reduced.

Abstract translation: 描述了含有可逆二硫键的制药，化学和生物制剂。 这些试剂也可以共价结合或包含在递送载体中，以将试剂递送到期望的靶或区域。 还描述了含有具有可逆二硫键接头的试剂和与含有可逆二硫键接头的试剂共价连接的载体的载体。 本文所述的修饰可以改变试剂和载体的性质，从而提供所需的溶解性，稳定性，疏水性和靶向性，而连接物的可逆性可以在其被还原后离开残留化学基团的试剂离开。

公开(公告)号：US08642546B2

公开(公告)日：2014-02-04

申请号：US13327504

申请日：2011-12-15

Applicant: Edward John Belouski ,  Murielle Marie Ellison ,  Agnes Eva Hamburger ,  Randy Ira Hecht ,  Yue-Sheng Li ,  Mark Leo Michaels ,  Jeonghoon Sun ,  Jing Xu

Inventor： Edward John Belouski ,  Murielle Marie Ellison ,  Agnes Eva Hamburger ,  Randy Ira Hecht ,  Yue-Sheng Li ,  Mark Leo Michaels ,  Jeonghoon Sun ,  Jing Xu

IPC: A61K38/18 ,  C07K14/50 ,  A61K39/395 ,  C07K16/00

CPC classification number: C07K14/50 ,  A61K38/00 ,  A61K38/1825 ,  A61K2039/505 ,  C07K16/18 ,  C07K2319/30

Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant fusion polypeptides comprising mutations at positions 98, 171, 179, 180 or 181, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

Abstract translation: 本发明提供编码FGF21突变融合多肽的核酸分子，其包含位置98,171,179,180或181，FGF21突变体多肽，包含FGF21突变体多肽的药物组合物的突变，以及使用此类核酸，多肽或 药物组合物。

公开(公告)号：US08458550B2

公开(公告)日：2013-06-04

申请号：US12920658

申请日：2009-02-24

Applicant: Haifeng Wang ,  Ting Zhou ,  Jing Xu

Inventor： Haifeng Wang ,  Ting Zhou ,  Jing Xu

IPC: H04L1/18

CPC classification number: H04W24/00 ,  H04B7/2606 ,  H04L1/0045 ,  H04L1/1607 ,  H04L1/1812 ,  H04L2001/0097 ,  H04W16/26 ,  H04W28/04 ,  H04W84/047

Abstract: Various example embodiments are disclosed herein. In an example embodiment, a method of transmitting data via a wireless transmission path that may include a user equipment as a first end point, a base station as second end point, and at least one relay station as an intermediate point(s). The method may include receiving a data transmission from a prior point in the transmission path. Substantially simultaneously: forwarding the received data to the next point in the transmission path, and determining if the received data is corrupt. Transmitting a transmission message to the next point in the transmission path indicating whether or not the received data was corrupt. And, if the data is not corrupt, transmitting a receipt message to the prior point indicating that the data was uncorrupt when received.

Abstract translation: 本文公开了各种示例性实施例。 在一个示例实施例中，一种经由无线传输路径发送数据的方法，该无线传输路径可以包括作为第一终点的用户设备，作为第二终点的基站和作为中间点的至少一个中继站。 该方法可以包括从传输路径中的先前点接收数据传输。 基本同时：将接收的数据转发到传输路径中的下一个点，并确定接收的数据是否已损坏。 将传输消息发送到传输路径中的下一个点，指示接收到的数据是否已损坏。 而且，如果数据没有被破坏，则将接收消息发送到先前点，表示数据在接收时未被破坏。

公开(公告)号：US08437637B2

公开(公告)日：2013-05-07

申请号：US12955730

申请日：2010-11-29

Applicant: Jing Xu ,  Lian-kuan Chen ,  Chun-kit Chan

Inventor： Jing Xu ,  Lian-kuan Chen ,  Chun-kit Chan

IPC: H04J14/00

CPC classification number: H04B10/272 ,  H04J14/0239 ,  H04J14/0246 ,  H04J14/025 ,  H04J14/0282 ,  H04J2014/0253

Abstract: Disclosed are a system and a method for controlling multicast data. The system may comprise: a plurality of transceivers, each of which comprises a laser configured to generate an optical carrier, the generated optical carrier being modulated by electrical downstream p-t-p data so as to generate optical downstream p-t-p IRZ signal; a PM configured to modulate the generated optical downstream p-t-p IRZ signal by electrical multicast data so as to generate orthogonally modulated signal; and a DI configured to demodulate the orthogonally modulated data and has a frequency response peak or dip in response to the demodulating, wherein an offset of a laser center wavelength of the laser from the frequency response peak or dip is adjustable so as to selectively enable or disable the multicast data.

Abstract translation: 公开了一种用于控制多播数据的系统和方法。 该系统可以包括：多个收发器，每个收发器包括被配置为产生光载波的激光器，所产生的光载波被电气下游p-t-p数据调制，以产生光下游p-t-p IRZ信号; 配置为通过电组播数据调制所生成的光下行p-t-p IRZ信号的PM，以产生正交调制信号; 以及配置为对所述正交调制数据进行解调并且响应于所述解调而具有频率响应峰值或倾角的DI，其中所述激光器的激光中心波长与所述频率响应峰值或倾角的偏移是可调节的，以便选择性地启用或 禁用组播数据。

公开(公告)号：US08431132B2

公开(公告)日：2013-04-30

申请号：US12555743

申请日：2009-09-08

Applicant: Haitao Wang ,  Du Yong ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

Inventor： Haitao Wang ,  Du Yong ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

IPC: A61K39/00 ,  C07K1/00 ,  C07K16/00

CPC classification number: C07K14/505 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/6811 ,  C07K2317/53 ,  C07K2319/30

Abstract: A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

Abstract translation: 描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。 与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。 在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。 与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。 在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。 融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。 在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。 本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

公开(公告)号：US08410051B2

公开(公告)日：2013-04-02

申请号：US13196544

申请日：2011-08-02

Applicant: Edward John Belouski ,  Murielle Marie Ellison ,  Agnes Eva Hamburger ,  Randy Ira Hecht ,  Yue-Sheng Li ,  Mark Leo Michaels ,  Jeonghoon Sun ,  Jing Xu

Inventor： Edward John Belouski ,  Murielle Marie Ellison ,  Agnes Eva Hamburger ,  Randy Ira Hecht ,  Yue-Sheng Li ,  Mark Leo Michaels ,  Jeonghoon Sun ,  Jing Xu

IPC: A61K38/18 ,  C07K14/50 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC classification number: C07K14/50 ,  A61K38/00 ,  A61K38/1825 ,  A61K2039/505 ,  C07K16/18 ,  C07K2319/30

Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

Abstract translation: 本发明提供编码FGF21突变体多肽，FGF21突变体多肽，包含FGF21突变体多肽的药物组合物的核酸分子，以及使用此类核酸，多肽或药物组合物治疗代谢紊乱的方法。