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104 条记录 (耗时 0.147 秒)

    Human DNase
    91.
    发明授权
    Human DNase 有权

    公开(公告)号：US06482626B2

    公开(公告)日：2002-11-19

    申请号：US10074509

    申请日：2002-02-11

    申请人： Kevin P. Baker ,  Will F. Baron

    发明人： Kevin P. Baker ,  Will F. Baron

    IPC分类号： C12N1555

    CPC分类号： C12N9/22 ,  A61K38/00

    摘要： This invention relates to a novel human deoxyribonuclease, referred to as LS-DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic acid sequences encoding LS-DNase, thereby enabling the production of LS-DNase by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of LS-DNase.

    Antibodies that specifically bind to GMAD
    92.
    发明申请
    Antibodies that specifically bind to GMAD 审中-公开
    特异性结合GMAD的抗体

    公开(公告)号：US20100292441A1

    公开(公告)日：2010-11-18

    申请号：US12320513

    申请日：2009-01-28

    申请人： Kevin P. Baker ,  Vivian R. Albert ,  Partha Chowdhury

    发明人： Kevin P. Baker ,  Vivian R. Albert ,  Partha Chowdhury

    IPC分类号： C07K16/18 ,  C12N5/16

    CPC分类号： A61K51/1018 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/26 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.

    摘要翻译： 本发明涉及免疫特异性结合GMAD的抗体和相关分子。 这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。 本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合GMAD的相关分子。

    Human Tumor Necrosis Factor Receptor TR17
    93.
    发明申请
    Human Tumor Necrosis Factor Receptor TR17 有权
    人类肿瘤坏死因子受体TR17

    公开(公告)号：US20090142353A1

    公开(公告)日：2009-06-04

    申请号：US12336051

    申请日：2008-12-16

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K39/395 ,  C07K14/00 ,  C07H21/04 ,  C12Q1/70 ,  A61P31/18 ,  C12N15/64 ,  C07K16/08

    CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7151

    摘要： The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR17. TR17 polypeptides are also provided as anti TR17 antibodies and vectors, host cells and recombinant methods for producing the same. The invention further relates to methods of killing cells using the antibodies of the invention.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的新型蛋白质TR17。 特别地，提供编码人TR17的分离的核酸分子。 还提供TR17多肽作为抗TR17抗体和载体，宿主细胞和用于制备其的重组方法。 本发明还涉及使用本发明的抗体杀死细胞的方法。

    Antibodies that specifically bind to GMAD
    94.
    发明授权
    Antibodies that specifically bind to GMAD 有权

    公开(公告)号：US07109302B1

    公开(公告)日：2006-09-19

    申请号：US10400442

    申请日：2003-03-28

    申请人： Kevin P. Baker ,  Vivian R. Albert ,  Viktor Roschke

    发明人： Kevin P. Baker ,  Vivian R. Albert ,  Viktor Roschke

    IPC分类号： C07K16/00 ,  C07K14/00

    CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.

    Human tumor necrosis factor receptors TR13 and TR14
    95.
    发明授权
    Human tumor necrosis factor receptors TR13 and TR14 失效
    人肿瘤坏死因子受体TR13和TR14

    公开(公告)号：US06951738B2

    公开(公告)日：2005-10-04

    申请号：US10046433

    申请日：2002-01-16

    申请人： Jian Ni ,  Kevin P. Baker ,  Steven M. Ruben ,  Paul E. Young

    发明人： Jian Ni ,  Kevin P. Baker ,  Steven M. Ruben ,  Paul E. Young

    IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N15/09 ,  C12Q1/68

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K14/7151

    摘要： The present invention relates to two novel proteins, TR13 and TR14, which are members of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR13 and TR14 proteins. TR13 and TR14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR13 and TR14.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的两种新型蛋白质TR13和TR14。 特别地，提供编码人TR13和TR14蛋白的分离的核酸分子。 还提供TR13和TR14多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR13和TR14的激动剂和拮抗剂的筛选方法。

    Nucleic acids encoding human tumor necrosis factor TR20
    96.
    发明授权
    Nucleic acids encoding human tumor necrosis factor TR20 失效
    编码人肿瘤坏死因子TR20的核酸

    公开(公告)号：US06623941B1

    公开(公告)日：2003-09-23

    申请号：US09848295

    申请日：2001-05-04

    申请人： Steven M. Ruben ,  Kevin P. Baker ,  Jian Ni

    发明人： Steven M. Ruben ,  Kevin P. Baker ,  Jian Ni

    IPC分类号： C12N1512

    CPC分类号： C07K14/525 ,  C07K14/70575

    摘要： The present invention relates to TR20 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR20 protein. TR20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR20 activity.

    摘要翻译： 本发明涉及TR20多肽。 特别地，提供编码人TR20蛋白的分离的核酸分子。 还提供TR20多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR20活性的激动剂和拮抗剂的筛选方法。

    Human DNase II
    98.
    发明授权
    Human DNase II 有权

    公开(公告)号：US06569429B1

    公开(公告)日：2003-05-27

    申请号：US09861034

    申请日：2001-05-18

    申请人： Kevin P. Baker ,  Will F. Baron

    发明人： Kevin P. Baker ,  Will F. Baron

    IPC分类号： A61K3846

    CPC分类号： C12N9/22 ,  A61K38/00

    摘要： This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of human DNase II by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and diagnostic and therapeutic uses of human DNase II.

    Human DNase II
    99.
    发明授权
    Human DNase II 失效
    人类DNA酶II

    公开(公告)号：US06265195B1

    公开(公告)日：2001-07-24

    申请号：US08639294

    申请日：1996-04-25

    申请人： Kevin P. Baker ,  Will F. Baron

    发明人： Kevin P. Baker ,  Will F. Baron

    IPC分类号： C12N916

    CPC分类号： C12N9/22 ,  A61K38/00

    摘要： This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of human DNase II by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and diagnostic and therapeutic uses of human DNase II.

    摘要翻译： 本发明涉及一种新的人脱氧核糖核酸酶，称为人类DNA酶II。 本发明提供了编码人DNase II的核酸序列，从而使得能够以足以临床使用的量的重组DNA方法生产人类DNA酶II。 本发明还涉及人类DNA酶II的药物组合物和诊断和治疗用途。

    Antibodies that specifically bind to GMAD
    100.
    发明授权
    Antibodies that specifically bind to GMAD 失效
    特异性结合GMAD的抗体

    公开(公告)号：US07550569B2

    公开(公告)日：2009-06-23

    申请号：US10935290

    申请日：2004-09-08

    申请人： Kevin P. Baker ,  Vivian R. Albert ,  Partha Chowdhury

    发明人： Kevin P. Baker ,  Vivian R. Albert ,  Partha Chowdhury

    IPC分类号： C12P21/08 ,  C07K16/00

    CPC分类号： A61K51/1018 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/26 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.

    摘要翻译： 本发明涉及免疫特异性结合GMAD的抗体和相关分子。 这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。 本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合GMAD的相关分子。