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公开(公告)号：US06482626B2
公开(公告)日：2002-11-19
申请号：US10074509
申请日：2002-02-11
申请人： Kevin P. Baker , Will F. Baron
发明人： Kevin P. Baker , Will F. Baron
IPC分类号： C12N1555
摘要： This invention relates to a novel human deoxyribonuclease, referred to as LS-DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic acid sequences encoding LS-DNase, thereby enabling the production of LS-DNase by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of LS-DNase.
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公开(公告)号：US20090041742A1
公开(公告)日：2009-02-12
申请号：US11740860
申请日：2007-04-26
申请人： Kevin P. Baker , Will F. Baron
发明人： Kevin P. Baker , Will F. Baron
摘要： This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of human DNase II by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and diagnostic and therapeutic uses of human DNase II.
摘要翻译： 本发明涉及一种新的人脱氧核糖核酸酶，称为人类DNA酶II。 本发明提供了编码人DNase II的核酸序列，从而使得能够以足以临床使用的量的重组DNA方法生产人类DNA酶II。 本发明还涉及人类DNA酶II的药物组合物和诊断和治疗用途。
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公开(公告)号：US07033796B2
公开(公告)日：2006-04-25
申请号：US10646760
申请日：2003-08-25
申请人： Kevin P. Baker , Will F. Baron
发明人： Kevin P. Baker , Will F. Baron
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K14/71 , C07K14/715 , C12N9/12 , C12Q1/485 , G01N33/54306 , G01N33/566 , G01N33/573 , G01N2333/705 , G01N2333/912 , G01N2333/9121 , G01N2500/00 , Y10S435/975
摘要： The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.
摘要翻译： 已经从人和/或鼠细胞组织中纯化称为Rse和HPTK6的蛋白酪氨酸激酶受体。 已经使用PCR扩增从人肝癌细胞系（即Hep 3B）的cDNA文库克隆了Rse和HPTK6。 本文提供了编码Rse和HPTK6的核酸序列，其可用作诊断和Rse和HPTK6的重组制备。 Rse和HPTK6用于制备和纯化其抗体和诊断测定。
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公开(公告)号：US06825324B2
公开(公告)日：2004-11-30
申请号：US09223490
申请日：1998-12-30
申请人： Kevin P. Baker , Will F. Baron
发明人： Kevin P. Baker , Will F. Baron
IPC分类号： C07K1600
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K14/71 , C07K14/715 , C12N9/12 , C12Q1/485 , G01N33/54306 , G01N33/566 , G01N33/573 , G01N2333/705 , G01N2333/912 , G01N2333/9121 , G01N2500/00 , Y10S435/975
摘要： The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.
摘要翻译： 已经从人和/或鼠细胞组织中纯化称为Rse和HPTK6的蛋白酪氨酸激酶受体。 已经使用PCR扩增从人肝癌细胞系（即Hep 3B）的cDNA文库克隆了Rse和HPTK6。 本文提供了编码Rse和HPTK6的核酸序列，其可用作诊断和Rse和HPTK6的重组制备。 Rse和HPTK6用于制备和纯化其抗体和诊断测定。
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公开(公告)号：US06087144A
公开(公告)日：2000-07-11
申请号：US447314
申请日：1995-05-22
申请人： David T. Scadden , Kevin P. Baker , Will F. Baron
发明人： David T. Scadden , Kevin P. Baker , Will F. Baron
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61P43/00 , C07H21/04 , C07K14/435 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/28 , C12N1/21 , C12N5/02 , C12N9/12 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/54 , C12P21/08 , C12Q1/48 , C12R1/19 , C12R1/91 , G01N33/543 , G01N33/566 , G01N33/573
CPC分类号： C07K16/28 , C07K14/705 , C07K14/71 , C07K14/715 , C12N9/12 , C12Q1/485 , G01N33/54306 , G01N33/566 , G01N33/573 , A61K38/00 , G01N2333/705 , G01N2333/912 , G01N2333/9121 , G01N2500/00 , Y10S435/975
摘要： The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.
摘要翻译： 已经从人和/或鼠细胞组织中纯化称为Rse和HPTK6的蛋白酪氨酸激酶受体。 已经使用PCR扩增从人肝癌细胞系（即Hep 3B）的cDNA文库克隆了Rse和HPTK6。 本文提供了编码Rse和HPTK6的核酸序列，其可用作诊断和Rse和HPTK6的重组制备。 Rse和HPTK6用于制备和纯化其抗体和诊断测定。
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公开(公告)号：US06569429B1
公开(公告)日：2003-05-27
申请号：US09861034
申请日：2001-05-18
申请人： Kevin P. Baker , Will F. Baron
发明人： Kevin P. Baker , Will F. Baron
IPC分类号： A61K3846
摘要： This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of human DNase II by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and diagnostic and therapeutic uses of human DNase II.
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公开(公告)号：US06265195B1
公开(公告)日：2001-07-24
申请号：US08639294
申请日：1996-04-25
申请人： Kevin P. Baker , Will F. Baron
发明人： Kevin P. Baker , Will F. Baron
IPC分类号： C12N916
摘要： This invention relates to a novel human deoxyribonuclease, referred to as human DNase II. The invention provides nucleic acid sequences encoding human DNase II, thereby enabling the production of human DNase II by recombinant DNA methods in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and diagnostic and therapeutic uses of human DNase II.
摘要翻译： 本发明涉及一种新的人脱氧核糖核酸酶，称为人类DNA酶II。 本发明提供了编码人DNase II的核酸序列，从而使得能够以足以临床使用的量的重组DNA方法生产人类DNA酶II。 本发明还涉及人类DNA酶II的药物组合物和诊断和治疗用途。
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