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221 条记录 (耗时 0.041 秒)

    Preparation of -4-thioalkybrobenzene derivatives
    92.
    发明授权
    Preparation of -4-thioalkybrobenzene derivatives 有权
    4-硫代烷基苯衍生物的制备

    公开(公告)号：US07301034B2

    公开(公告)日：2007-11-27

    申请号：US10332861

    申请日：2001-07-17

    申请人： Rene Lochtman ,  Michael Keil ,  Joachim Gebhardt ,  Michael Rack ,  Wolfgang von Deyn

    发明人： Rene Lochtman ,  Michael Keil ,  Joachim Gebhardt ,  Michael Rack ,  Wolfgang von Deyn

    IPC分类号： C07D261/04 ,  C07D261/08

    CPC分类号： C07D413/04 ,  C07C319/14 ,  C07D261/04 ,  C07C323/62

    摘要： A process for preparing 4-thioalkylbromobenzene derivatives of the formula I where: R1 is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, halogen, R2 is C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical, R3 is C1-C6-alkyl, which comprises reacting a compound of the formula II, in which R1 and R2 are as defined above, with a dialkyl disulfide of the formula III R3—S—S—R3III in the presence of a nitrite and a catalyst in a suitable solvent is described.

    摘要翻译： 制备式I的4-硫代烷基溴苯衍生物的方法，其中：R 1是C 1 -C 6 - 烷基，C 1 -C 6 - C 1 -C 6 - 卤代烷基，C 1 -C 6 - 烷氧基，C 1 -C 6 - C 6 - 卤代烷氧基，C 3 -C 8 - 环烷基，卤素，R 2是C 1 -C 6烷基， C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，C 3 - C 8 - 环烷基，C 2 -C 6 - 烯基，氰基或杂环基，R 3是 C 1 -C 6 - C 6 - 烷基，其包括使式II化合物（其中R 1和R 2） / SUP>如上所定义，与式III的二烷基二硫化物<？in-line-formula description =“In-line Formulas”end =“lead”？> R 3 -SSR < 描述了在合适的溶剂中存在亚硝酸盐和催化剂的情况下，在实施例3中描述的“In-line-formula description =”In-Line Formulas“end =”tail“？>

    Process for manufacturing 5-formyl-pyridine-2,3-dicarboxylic acid esters
    94.
    发明授权
    Process for manufacturing 5-formyl-pyridine-2,3-dicarboxylic acid esters 有权
    5-甲酰基 - 吡啶-2,3-二羧酸酯的制备方法

    公开(公告)号：US08629279B2

    公开(公告)日：2014-01-14

    申请号：US13133013

    申请日：2009-12-07

    申请人： Michael Rack ,  Joachim Gebhardt ,  Frederik Menges ,  Michael Keil ,  Rodney F. Klima ,  David Cortes ,  Robert Leicht ,  Helmut Zech ,  Jochen Schröder

    发明人： Michael Rack ,  Joachim Gebhardt ,  Frederik Menges ,  Michael Keil ,  Rodney F. Klima ,  David Cortes ,  Robert Leicht ,  Helmut Zech ,  Jochen Schröder

    IPC分类号： C07D213/48 ,  C07D213/55

    CPC分类号： C07D213/80

    摘要： A process for manufacturing a 5-formyl-pyridine-2,3-dicarboxylic acid ester (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro and R1, R2 are independently C1-C10-alkyl, comprising the steps of (i) reacting a compound of formula (II), wherein the symbols are as in formula (I), with a nitrosation agent (III) R3—O—N═O (III) wherein R3 is C1-C8-alkyl, in the presence of an alkali metal or alkaline earth metal alcoholates or carbonates in a polar aprotic solvent at a temperature of from −45 to 40° C., to obtain an oxime compound (IV) where Z, Z1, R1 and R2 are as in formula (I), and (ii) reacting oxime compound (IV) with an aliphatic C1-C10-aldehyde in the presence of a Lewis acid at a temperature in the range of from 0 to 100° C. The compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox.

    摘要翻译： 制备其中Z为氢或卤素的5-甲酰基 - 吡啶-2,3-二羧酸酯（I）的方法; Z1是氢，卤素，氰基或硝基，R1，R2独立地是C1-C10-烷基，包括以下步骤：（ⅰ）使符号如式（I）所示的式（ⅱ）化合物与式 在碱金属或碱土金属醇盐或碳酸盐存在下，在极性非质子溶剂中，温度为-45〜40℃的亚硝化剂（Ⅲ）R3-ON = O（Ⅲ）其中R3为C1-C8-烷基 ℃，得到其中Z，Z 1，R 1和R 2如式（I）中的肟化合物（Ⅳ），和（ⅱ）使肟化合物（Ⅳ）与脂族C 1 -C 10 - 醛在 在0至100℃的温度范围内的路易斯酸。式（I）化合物是合成除草咪唑啉酮如咪唑氧化物的有用中间体。

    Method for production of aryl-substituted annelated pyrimidines
    95.
    发明申请
    Method for production of aryl-substituted annelated pyrimidines 审中-公开
    芳基取代的环状嘧啶的制备方法

    公开(公告)号：US20100087640A1

    公开(公告)日：2010-04-08

    申请号：US12521877

    申请日：2008-01-10

    申请人： Bernd Wolf ,  Volker Maywald ,  Michael Keil ,  Manuel Budich ,  Michael Rack ,  Manfred Ehresmann

    发明人： Bernd Wolf ,  Volker Maywald ,  Michael Keil ,  Manuel Budich ,  Michael Rack ,  Manfred Ehresmann

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention relates to a process for preparing aryl-substituted fused pyrimidines of the general formula (I) in which L1 to L5 are H, halogen, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy etc.; Y1 to Y3 are C—RY or N; RY is H or optionally substituted C1-C4-alkyl or two adjacent RY together form a ring; X is OH, Cl or Br; which comprises (i) the reaction of a 2-phenylmalonate with a compound (III) or a tautomer thereof, in the presence of a suitable base, where the alcohol, released during the reaction, of the formula R—OH is continuously removed from the reaction mixture under reduced pressure; giving a compound of the formula (I) or a salt thereof in which X is OH, and, if X in the compounds of the general formula (I) is chlorine or bromine, (ii) the reaction of the compounds of the formula (I) obtained in step (i) or the salts with a halogenating agent.

    摘要翻译： 本发明涉及制备通式（I）的芳基取代的稠合嘧啶的方法，其中L 1至L 5为H，卤素，CN，NO 2，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4 - 烷氧基，C1-C4-卤代烷氧基等; Y1至Y3为C-RY或N; RY为H或任选取代的C 1 -C 4烷基或两个相邻的RY一起形成环; X是OH，Cl或Br; 其包括（i）2-苯基丙二酸酯与化合物（III）或其互变异构体在合适的碱的存在下反应，其中反应期间释放的醇与式R-OH的连续从 减压下的反应混合物; 得到其中X是OH的式（I）化合物或其盐，并且如果通式（I）的化合物中的X是氯或溴，则（ii）式（I）化合物 I）或与卤化剂的盐。