摘要:
A phenylalanine derivative having the formula (I): ##STR1## wherein A represents ##STR2## B represents ##STR3## wherein m is 0, 1, or 2 and n is 3, 4, or 5; X represents (a) hydroxy, (b) nitro, (c) amino, (d) phenoxy which may be substituted with (i) halogen or (ii) nitro, (e) c.sub.1 -C.sub.4 alkyloxy which may be substituted wit (i) phenyl or (ii) benzoyl, (f) benzoyl, (g) pyridyloxy which may be substituted with (i) halogen or (ii) nitro, or (h) c.sub.1 -C.sub.4 alkyl which may by substituted with halogen;Y represents ##STR4## or --OR.sup.3 wherein R.sup.1 R.sup.2 are independently (a) hydrogen, (b) phenyl which may be substituted with (i) benzoyl, (ii) C.sub.1 -C.sub.4 alkylcarbonyl, (iii) C.sub.1 -C.sub.4 alkyl which may be further substituted with C.sub.1 -C.sub.4 alkoxycarbonyl or hydroxycarbonyl, (iv) C.sub.2 -C.sub.5 alkenyl which may be further substituted with hydroxycarbonyl or C.sub.1 -C.sub.4 alkoxycarbonyl, (v) C.sub.1 -C.sub.4 alkoxycarbonyl, or (vi) amidino, (c) pyridyl which may be substituted with halogen or carboxyl (d) imidazolyl, (e) pyrimidyl, (f) tetrazolyl, (g) thiazolyl which may be substituted with C.sub.1 -C.sub.4 alkyl which may be further substituted with C.sub.1 -C.sub.4 alkoxycarbonyl, (h) C.sub.1 -C.sub.6 alkyl which may be substituted with C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkoxycarbonyl, phenyl, or benzoyl, (i) C.sub.5 -C.sub.7 cycloalkyl which may be substituted with C.sub.1 -C.sub.4 alkoxycarbonyl or (j) R.sup.1 and R.sup.2 may form, with the nitrogen atom attached thereto, (i) pyperazyl which may be substituted on the nitrogen atom with C.sub.1 -C.sub.4 alkyl which may be further substituted with phenyl, (ii) piperidino which may be substituted with carboxyl or C.sub.1 -C.sub.4 alkoxycarbonyl, (iii) pyrrolidyl which may be substituted with C.sub.1 -C.sub.4 alkoxycarbonyl, or (iv) morpholyl; andR.sup.3 represents (a) hydrogen, (b) C.sub.1 -C.sub.6 alkyl which may be substituted with (i) C.sub.1 -C.sub.4 alkoxy, (ii) pehnyl, or (iii) pyridyl, or (c) pyridyl; or a pharmaceutically acceptable acid salt thereof.This phenylalanine derivative is effective as a proteinase.
摘要:
Disclosed herein are a solvent for a chromogenic dye-precursor material for a pressure-sensitive recording paper sheet, comprising (1) 30 to 80% by weight of p-monoisopropylbiphenyl or a biphenyl mixture of not less than 80% by weight of p-monoisopropylbiphenyl, not more than 20% by weight of m-monoisopropylbiphenyl and not more than 10% by weight of diisopropylbiphenyl, and (2) 70 to 20% by weight of diisopropylnaphthalene or a naphthalene mixture of not less than 97% by weight of diisopropylnaphthalene, not more than 1% by weight of monoisopropylnaphthalene and not more than 2% by weight of triisopropylnaphthalene, and a pressure-sensitive recording paper sheet prepared by using the solvent.
摘要:
A rotary cutter which includes an elongated handle having an aperture extending through its one end, a shaft extending through the aperture so as to be supported by the handle, a disc blade rotatably mounted on the shaft and lying in a plane perpendicular to the longitudinal axis of the shaft, and a member engageable with the shaft, with a bearing projection formed on the handle coaxially with the aperture.
摘要:
A handy safety knife comprises a generally flat holder having a chamber and an opening both defined therein, an elongated blade member, a manipulatable member carried by the holder for movement between projected and retracted position and operatively coupled to the blade member, a spring element for biasing the manipulatable member to the retracted position to hold the blade member in position to be concealed within the chamber, and, if desired, a wedge member for retaining the manipulatable member in the projected position once it has been moved thereto.
摘要:
An absorbant for use in artificial organs which is obtained by mixing and dissolving pitch with an aromatic compound and a polymer or copolymer of a chain hydrocarbon, dispersing the resultant mixture in water giving rise to beads and subjecting these beads to a series of treatments of removing of the aromatic hydrocarbon, infusibilizing, carbonizing and activating.
摘要:
A cutting device comprises a holder including a pair of spaced plate members connected at one peripheral edge to each other to define an accommodation space therebetween. A cutting disc is, either rotatably or fixedly, mounted on a shaft member and situated within the accommodation space. Rotatably mounted on the shaft member and arranged in the vicinity of and side-by-side relation to the cutting disc is at least one padding disc which acts to retain a material to be cut in position during rotation thereof. Rotation of the padding disc is effected in contact with the material as the cutting device is moved along an intended line of cutting during actual cutting operation.
摘要:
A magnetographic camera may be based on an optically pumped magnetometer (OPM). The magnetographic camera may measure a spatial distribution of magnetic field produced by a sample that may be stationary in time or may dynamically vary with time. The magnetographic camera may include a magnetic field detector housing containing a vapor cell. The magnetographic camera may include a laser light source to illuminate the vapor cell causing a magnetic field image of a sample to be generated. The magnetographic camera may include an optical detector to encode and store the magnetic field image of the sample that is spatially encoded as a distribution of light.
摘要:
The present invention provides a magnesium alloy material, having superior mechanical properties without using special production equipment or processes, and a production process thereof. The magnesium alloy material of the present invention composed of an Mg—Zn—RE alloy comprises essential components in the form of 0.5 to 3 atomic percent of Zn and 1 to 5 atomic percent of RE, with the remainder comprising Mg and unavoidable impurities. The Mg—Zn—RE alloy has a lamellar phase formed from a long period stacking ordered structure and α-Mg in the alloy structure thereof. The long period stacking ordered structure has at least one of a curved portion and a bent portion and has a divided portion in at least a portion thereof. Finely granulated α-Mg having a mean particle diameter of 2 μm or less is formed in the divided portion.
摘要:
A surface-coated cutting tool excellent in wear resistance is provided. The surface-coated cutting tool of the present invention includes a base material and a coating formed on the base material. The coating includes an inner layer and an outer layer. The inner layer is a single layer or a multilayer stack constituted of two or more layers made of at least one element selected from the group consisting of group IVa elements, group Va elements, group VIa elements in the periodic table, Al, and Si, or a compound of at least one element selected from this group and at least one element selected from the group consisting of carbon, nitrogen, oxygen, and boron. The outer layer includes α-aluminum oxide as a main component and exhibits an equivalent peak intensity PR(024) of a (024) plane of x-ray diffraction of larger than 1.3.
摘要:
The surface-coated cutting tool of the present invention is characterized in that a region of 10 μm in a surface of the base material from point a′ to point b′ has two to seven cracks with a width of not more than 200 nm, or two to ten pores are present per length of 10 μm in the surface of the base material from point a′ to point b′, where points a′ and b′ are points defined respectively by lines drawn perpendicularly from points a and b to the surface of the base material where point a is a position located away from an edge ridgeline toward a rake face by distance La and point b is a position located away from the edge ridgeline toward a flank face by distance Lb.