Flexible endoscope
    91.
    发明授权
    Flexible endoscope 失效
    灵活的内窥镜

    公开(公告)号:US5058568A

    公开(公告)日:1991-10-22

    申请号:US459719

    申请日:1990-01-26

    IPC分类号: A61B1/00

    CPC分类号: A61B1/00071 A61B1/0051

    摘要: A flexible endoscope has at least one outer protective coat, one protective mesh and elements arranged in the distal region, which are connected via a series of connecting lines for data and/or energy transmission to the connection element arranged at the opposite end. The mesh includes a plurality of conductive lines which are electrically insulated from each other. The connecting lines are included among the conducting lines of the mesh.

    摘要翻译: PCT No.PCT / DE89 / 00328 Sec。 371 1990年1月26日第 102(e)日期1990年1月26日PCT提交1989年5月28日PCT公布。 出版物WO89 / 11242 柔性内窥镜具有至少一个外保护层,一个保护网和布置在远端区域中的元件,其经由一系列用于数据和/或能量传输的连接线连接到布置的连接元件 在另一端 网格包括彼此电绝缘的多条导线。 连接线包括在网格的导线之中。

    Detection of antibody that binds to water soluble polymer-modified polypeptides
    95.
    发明授权
    Detection of antibody that binds to water soluble polymer-modified polypeptides 有权
    检测结合水溶性聚合物修饰多肽的抗体

    公开(公告)号:US08216793B2

    公开(公告)日:2012-07-10

    申请号:US12786641

    申请日:2010-05-25

    IPC分类号: G01N33/566

    CPC分类号: G01N33/6854

    摘要: The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.

    摘要翻译: 本发明提供了检测个体抗体抗体的分析方法。 所述方法包括使来自个体的样品与水溶性聚合物修饰的载体接触并检测抗体与水溶性聚合物修饰的载体上的水溶性聚合物的结合,其中结合指示抗体存在于聚合物修饰的水 多肽。 可以对水溶性聚合物如聚乙二醇,聚唾液酸,葡聚糖,羟烷基淀粉或羟乙基淀粉检测抗体。 当检测到对水溶性聚合物聚乙二醇的抗体时,用非线性聚乙二醇衍生物修饰载体。

    Prevention and treatment of ischemic events and reperfusion injury
resulting therefrom using lys-plasminogen
    98.
    发明授权
    Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen 失效
    使用lys-plasminogen预防和治疗由此导致的缺血事件和再灌注损伤

    公开(公告)号:US5520912A

    公开(公告)日:1996-05-28

    申请号:US257626

    申请日:1994-06-08

    CPC分类号: A61K38/484 Y10S514/802

    摘要: A treatment of ischemia and the attendant reperfusion injury entails the administration plasmin and plasmin-forming proteins, including lys-plasminogen and similar substances. Lys-plasminogen, which can be obtained from the proteolytic cleavage of glu-plasminogen, has been found to have a protective effect on tissue that has been injured by ischemic conditions. The administration of lys-plasminogen can used to treat subjects during the time of reperfusion and after reperfusion has already occurred. Lys-plasminogen also can be administered in conjunction with clot lysis therapies, such as those that employ tissue plasminogen activator and the like.

    摘要翻译: 缺血和伴随的再灌注损伤的治疗需要施用纤溶酶和纤溶酶形成蛋白,包括溶酶原纤溶酶原和类似物质。 已经发现,可以从葡萄糖分解纤维蛋白溶酶原的蛋白水解切割中获得的Lys-plasminogen对缺血条件损伤的组织具有保护作用。 溶血纤溶酶原的施用可以在再灌注期间和再灌注已经发生后用于治疗受试者。 Lys-纤溶酶原也可以与凝块溶解疗法结合使用,例如使用组织纤溶酶原激活剂等的那些。