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1.发明申请Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof 有权透明质酸酶和免疫球蛋白的稳定共配方及其使用方法公开(公告)号：US20110066111A1
公开(公告)日：2011-03-17
申请号：US12807991
申请日：2010-09-16
申请人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
发明人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
摘要翻译： 本文提供了免疫球蛋白和透明质酸酶的稳定共配方，其在室温下以液体形式储存至少6个月，并在标准冰箱温度下保存1-2年。 这种共同制剂可用于通过皮下给药治疗IG治疗性疾病或病症的方法。
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2.发明授权Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof 有权透明质酸酶和免疫球蛋白的稳定共配方及其使用方法公开(公告)号：US09084743B2
公开(公告)日：2015-07-21
申请号：US12807991
申请日：2010-09-16
申请人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
发明人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
摘要翻译： 本文提供了免疫球蛋白和透明质酸酶的稳定共配方，其在室温下以液体形式储存至少6个月，并在标准冰箱温度下保存1-2年。 这种共同制剂可用于通过皮下给药治疗IG治疗性疾病或病症的方法。
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公开(公告)号：US09783792B2
公开(公告)日：2017-10-10
申请号：US12617578
申请日：2009-11-12
申请人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
发明人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
CPC分类号： C12N9/18
摘要： The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
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公开(公告)号：US20100226907A1
公开(公告)日：2010-09-09
申请号：US12617578
申请日：2009-11-12
申请人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
发明人： Alexander Zaydenberg , Susan Weber , Patrick Gavit , Laura Lei , Wolfgang Teschner , Harald A. Butterweck , Ursula Mais-Paul , Hans-Peter Schwarz
CPC分类号： C12N9/18
摘要： The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
摘要翻译： 本发明涉及使用阴离子交换材料纯化丁酰胆碱酯酶，其中丁酰胆碱酯酶含量在组合物中富集至少10倍于总蛋白。
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