公开(公告)号：US20070141612A1

公开(公告)日：2007-06-21

申请号：US11639025

申请日：2006-12-14

Applicant: Sanjay Kumar

Inventor： Sanjay Kumar

IPC: C12Q1/68 ,  G01N33/53 ,  G06F19/00

CPC classification number: G16B20/00 ,  G16B30/00 ,  G16B50/00

Abstract: Methods and compositions are provided for selecting drug targets in silico, that include the following steps performed in the order presented or an alternative order of partially or entirely at the same time: (a) identifying one or more essential or functionally important sequences from a model organism using pre-existing genomic and phenotypic data; (b) comparing sequences from (a) with a DNA or peptide sequence from a pathogen to store homologous sequences; (c) comparing sequences from the pathogen with the DNA or peptide sequence from a host organism to store those sequences absent in the host organism; and (d) comparing sequences from (b) and (c) to identify shared sequences, the shared sequences being a drug target. Additionally, identified drug targets are provided.

Abstract translation: 提供了用于选择药物靶标的方法和组合，其包括按照所列顺序进行的以下步骤或部分或完全同时的替代顺序：（a）从模型中鉴定一个或多个必需或功能重要的序列 生物体使用预先存在的基因组和表型数据; （b）将来自（a）的序列与来自病原体的DNA或肽序列进行比较以存储同源序列; （c）将来自病原体的序列与来自宿主生物体的DNA或肽序列进行比较以存储在宿主生物体中不存在的那些序列; 和（d）比较来自（b）和（c）的序列以鉴定共享序列，所述共享序列是药物靶标。 此外，还提供了确定的药物靶标。

公开(公告)号：US20070042379A1

公开(公告)日：2007-02-22

申请号：US10585964

申请日：2004-11-22

Applicant: Chudi Guan ,  Sanjay Kumar ,  Rebecca Kucera

Inventor： Chudi Guan ,  Sanjay Kumar ,  Rebecca Kucera

IPC: C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/22

CPC classification number: C12N9/22

Abstract: Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one mutation having an effect of altering enzyme cleavage activity compared to the unmodified enzyme. Activities associated with the modified DNA cleaving enzyme that can be modulated in different reaction conditions include at least one of: (a) non-sequence specific nicking activity; (b) cleaving the second strand of a duplex DNA at a preexisting nick site to produce a linear duplex with a single strand overhang; (c) non-sequence specific DNA cleavage; (d) cleaving DNA flanking a mismatch; and (e) cleavage at a cruciform structure in a DNA duplex.

Abstract translation: 提供了与T7 Endo I具有至少35％氨基酸序列同一性的修饰的DNA切割酶的组合物和方法。修饰的酶包括由β桥分开的两个催化中心，其中β-桥含有至少一个突变 与未修饰的酶相比具有改变酶裂解活性的作用。 与可以在不同反应条件下调节的修饰的DNA切割酶相关的活性包括以下至少一个：（a）非序列特异性切口活性; （b）在预先存在的切口位点切割双链体DNA的第二链以产生具有单链突出端的线性双链体; （c）非序列特异性DNA切割; （d）切断位于不对称侧翼的DNA; 和（e）在DNA双链体中的十字形结构处的切割。

公开(公告)号：US06988641B2

公开(公告)日：2006-01-24

申请号：US10662467

申请日：2003-09-16

Applicant: Brian C. Jones ,  David N. Evans ,  Scott A. Dzibela ,  John C. Nordenstrom ,  Sanjay Kumar ,  Russell J. Duchene ,  Allen L. Rogala ,  Michael J. Fodor ,  William K. Henninger ,  Amir A. Faroqui

Inventor： Brian C. Jones ,  David N. Evans ,  Scott A. Dzibela ,  John C. Nordenstrom ,  Sanjay Kumar ,  Russell J. Duchene ,  Allen L. Rogala ,  Michael J. Fodor ,  William K. Henninger ,  Amir A. Faroqui

IPC: B67D5/56

CPC classification number: B67D1/0037 ,  A47J31/41 ,  A47J31/46 ,  A47J31/60 ,  B67D2210/00102

Abstract: A beverage dispensing apparatus includes a dispensing device, at least one valve that distributes a diluent, a concentrate pump that distributes concentrate, a support structure that supports the foregoing components and exterior cladding attached to the support structure. The exterior cladding provides the appearance of a real leaf tea brewer. The diluent valve and concentrate pump distribute the diluent and concentrate into the dispensing device to form a mixture to be dispensed therefrom. The diluent can be hot water and the apparatus further includes an air ejector device for eliminating air bubbles from the hot water prior to mixing. In addition, an improved sensor can accurately determine when the supply of concentrate is depleted.

Abstract translation: 饮料分配装置包括分配装置，至少一个分配稀释剂的阀，分配浓缩物的浓缩物泵，支撑前述组分的支撑结构和附着到支撑结构的外部包层。 外部包层提供真正的叶茶酿造者的外观。 稀释剂阀和浓缩泵将稀释剂分配并分配到分配装置中以形成从其分配的混合物。 稀释剂可以是热水，并且该装置还包括用于在混合之前从热水中除去气泡的空气喷射装置。 此外，改进的传感器可以准确地确定浓缩物的供应何时耗尽。

公开(公告)号：US20050166761A1

公开(公告)日：2005-08-04

申请号：US11094057

申请日：2005-03-30

Applicant: Brian Jones ,  Sanjay Kumar ,  Scott Dzibela ,  Fernando Ubidia ,  Mark Tauer

Inventor： Brian Jones ,  Sanjay Kumar ,  Scott Dzibela ,  Fernando Ubidia ,  Mark Tauer

IPC: A47J31/40 ,  A47J31/00

CPC classification number: A47J31/402

Abstract: A beverage dispensing apparatus includes a mixing chamber for mixing hot water, a beverage concentrate and cold water, as well as one or more additives. The hot water and cold water are supplied at a predetermined flow rate at a predetermined proportion, regardless of the pressure of the water supply. A water heater supplies the hot water within a specified pressure range and without significant entrapped air.

公开(公告)号：US06350856B1

公开(公告)日：2002-02-26

申请号：US09047288

申请日：1998-03-24

Applicant: Sanjay Kumar

Inventor： Sanjay Kumar

IPC: C07K100

CPC classification number: C07K14/705 ,  A61K38/00 ,  Y02A50/411

Abstract: p38beta2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing p38beta2 polypeptides and polynucleotides in the design of protocols for the treatment of central nervous system disorder such as senile dementia of the Alzheimer's type (SDAT), multiple sclerosis, cerebral malaria, stroke, head trauma and spinal cord injury; cardiovascular diseases such as restenosis and atherosclerosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma; and other such diseases or conditions associated with dysregulated or excess cytokines such as osteporosis, sepsis due to surgical or traumatic incident, chronic renal failure, AIDs, cachexia and autoimmune conditions such as lupus erthyromatosis, host graft rejection and graft versus host disease, among others, and diagnostic assays for such conditions.

Abstract translation: 公开了p38beta2多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗中枢神经系统疾病的方案中使用p38beta2多肽和多核苷酸的方法，例如阿尔茨海默氏型（SDAT）的老年性痴呆，多发性硬化，脑疟疾，中风，头部创伤和脊髓损伤; 心血管疾病如再狭窄和动脉粥样硬化; 炎性疾病如成人呼吸系统综合症（ARDS），类风湿性关节炎，骨关节炎，炎性肠病（IBD），牛皮癣，皮炎，哮喘; 以及与失调或过量细胞因子相关的其它这样的疾病或病症，例如由于手术或创伤事件引起的异位症，败血症，慢性肾衰竭，AIDs，恶病质和自身免疫病症如狼疮性甲状腺病，宿主移植排斥和移植物抗宿主病等 ，以及这些病症的诊断测定。

公开(公告)号：US5944777A

公开(公告)日：1999-08-31

申请号：US851527

申请日：1997-05-05

Applicant: Sanjay Kumar ,  Sudarshan Kumar

Inventor： Sanjay Kumar ,  Sudarshan Kumar

IPC: G06F7/50 ,  G06F7/508

CPC classification number: G06F7/508

Abstract: An adder circuit to generate carry-outs and a method implemented by the adder circuit. First and second groups of consecutive group generate terms are calculated. The first group of group generate terms are combined to calculate a first result at a first logic level, and the second group of group generate terms are combined to calculate a second result at the same logic level. The first and second results are then combined to calculate a carry-out at a second logic level.

Abstract translation: 用于产生进位的加法器电路和由加法器电路实现的方法。 计算第一组和第二组连续组生成项。 将组的第一组生成术语组合以计算第一逻辑电平的第一结果，并且组合第二组组生成术语以在相同逻辑电平处计算第二结果。 然后组合第一和第二结果以在第二逻辑电平计算进位输出。

公开(公告)号：US5835850A

公开(公告)日：1998-11-10

申请号：US693685

申请日：1996-08-12

Applicant: Sanjay Kumar

Inventor： Sanjay Kumar

IPC: H04B1/38 ,  H04B7/02 ,  H04B17/00 ,  H04Q7/34

CPC classification number: H04B17/15 ,  H04B17/17 ,  H04B17/19

Abstract: An integrated radio frequency transceiver comprising a diversity receiver and transmitter capable of performing a self test operation to determine if the receiver and transmitter paths are properly operational. The diversity receiver includes two receiver paths, a first path for receiving radio communications having a permitted bandpass, and a second receiver path for receiving radio signals from other radio port channels in use to assist in constructing its own neighbor list.

Abstract translation: 包括分集接收机和发射机的集成射频收发机，其能够执行自检操作以确定接收机和发射机路径是否正常工作。 分集接收机包括两个接收机路径，用于接收具有允许带通的无线电通信的第一路径和用于从其他无线电端口信道接收来自辅助构建其自己的邻居列表的无线电信号的第二接收机路径。

公开(公告)号：US20160179667A1

公开(公告)日：2016-06-23

申请号：US14580632

申请日：2014-12-23

Applicant: Sanjay Kumar ,  Rajesh M. Sankaran ,  Subramanya R. Dulloor ,  Andrew V. Anderson

Inventor： Sanjay Kumar ,  Rajesh M. Sankaran ,  Subramanya R. Dulloor ,  Andrew V. Anderson

IPC: G06F12/08

CPC classification number: G06F12/0804 ,  G06F9/467 ,  G06F11/07 ,  G06F11/073 ,  G06F11/0778 ,  G06F11/0793 ,  G06F11/14 ,  G06F11/1482 ,  G06F12/0868 ,  G06F2201/805 ,  G06F2201/82 ,  G06F2212/1032 ,  G06F2212/608

Abstract: A processor includes a memory management unit and a front end including a decoder. The decoder includes logic to receive a flush-on-commit (FoC) instruction to flush dirty data from a volatile cache to a persistent memory upon commitment of a store associated with the FoC instruction. The memory management unit includes logic to, based upon a flush-on-fail (FoF) mode, skip execution of the flush-on-commit instruction and to flush the dirty data from the volatile cache upon a subsequent FoF operation.

Abstract translation: 处理器包括存储器管理单元和包括解码器的前端。 解码器包括用于在与FoC指令相关联的存储的承诺时接收刷新提交（FoC）指令以将脏数据从易失性高速缓冲器刷新到持久存储器的逻辑。 存储器管理单元包括基于刷新失败（FoF）模式的逻辑，跳过刷新提交指令的执行，并且在随后的FoF操作时从易失性高速缓存清除脏数据。

公开(公告)号：US09069730B2

公开(公告)日：2015-06-30

申请号：US12493602

申请日：2009-06-29

Applicant: Vanish Talwar ,  Sanjay Kumar ,  Parthasarathy Ranganathan

Inventor： Vanish Talwar ,  Sanjay Kumar ,  Parthasarathy Ranganathan

IPC: G06F9/455 ,  G06F9/46 ,  G06F11/00 ,  G06F11/20 ,  G06F11/30 ,  G06F11/07

CPC classification number: G06F11/203 ,  G06F9/45558 ,  G06F11/004 ,  G06F11/0754 ,  G06F11/301 ,  G06F11/3089 ,  G06F2009/45562 ,  G06F2201/815

Abstract: A system and methods for reliability management of virtual machines in a host system. The reliability of the host system is monitored and compared with a reliability threshold level for a virtual machine. If the reliability of the host system drops below the reliability threshold level, the virtual machine is migrated to another host system having an appropriate level of reliability.

Abstract translation: 主机系统中虚拟机可靠性管理的系统和方法。 监控主机系统的可靠性，并与虚拟机的可靠性阈值级别进行比较。 如果主机系统的可靠性降低到可靠性阈值水平以下，则虚拟机将迁移到具有适当可靠性水平的另一个主机系统。

公开(公告)号：US09047108B1

公开(公告)日：2015-06-02

申请号：US13607463

申请日：2012-09-07

Applicant: Subash Rajaa ,  Sanjay Kumar

Inventor： Subash Rajaa ,  Sanjay Kumar

IPC: G06F9/455 ,  G06F9/48

CPC classification number: G06F9/455 ,  G06F3/065 ,  G06F9/45558 ,  G06F9/4856 ,  G06F2009/45562 ,  G06F2009/4557 ,  G06F2009/45575

Abstract: A computer-implemented method for migrating replicated virtual machine disks may include 1) replicating a virtual machine disk from an initial data store at a primary site to an initial data store at a secondary site to create a replicated virtual machine disk, 2) identifying a request to migrate the virtual machine disk within the primary site, 3) pausing replication of the virtual machine disk and mirroring the virtual machine disk from the initial data store a subsequent data store at the primary site, mirroring the replicated virtual machine disk from the initial data store to a subsequent data store at the secondary site, and 4) upon mirroring, resuming replication of the virtual machine disk by replicating the virtual machine disk from the subsequent data store at the primary site to the subsequent data store at the secondary site. Various other methods, systems, and computer-readable media are also disclosed.

Abstract translation: 用于迁移复制的虚拟机磁盘的计算机实现的方法可以包括：1）将虚拟机磁盘从主站点的初始数据存储复制到次要站点处的初始数据存储以创建复制的虚拟机磁盘，2）识别 请求迁移主站点中的虚拟机磁盘，3）暂停虚拟机磁盘的复制，并从初始数据存储虚拟机磁盘，存储主站点上的后续数据存储，从初始镜像镜像复制的虚拟机磁盘 数据存储到辅助站点处的后续数据存储，以及4）在镜像之后，通过将虚拟机磁盘从主站点处的后续数据存储复制到辅助站点处的后续数据存储来恢复虚拟机磁盘的复制。 还公开了各种其它方法，系统和计算机可读介质。