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338 条记录 (耗时 0.056 秒)

    MYBL2 PEPTIDES AND VACCINES CONTAINING THE SAME
    91.
    发明申请
    MYBL2 PEPTIDES AND VACCINES CONTAINING THE SAME 审中-公开
    MYBL2肽和含有其的疫苗

    公开(公告)号：US20120328638A1

    公开(公告)日：2012-12-27

    申请号：US13513543

    申请日：2010-12-02

    申请人： Yusuke Nakamura ,  Takuya Tsunoda ,  Ryuji Ohsawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe

    发明人： Yusuke Nakamura ,  Takuya Tsunoda ,  Ryuji Ohsawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe

    IPC分类号： A61K39/00 ,  C12N15/12 ,  A61P35/00 ,  C12N5/0783 ,  C12N5/0784 ,  C12N15/85 ,  C12N5/10 ,  C07K7/08 ,  A61K31/7088

    CPC分类号： C07K14/82 ,  A61K39/0011 ,  C07K14/4748

    摘要： Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the MYBL2 gene that bind to HLA antigen and have cytotoxic T lymphocyte (CTL) inducibility, more particularly peptides having the amino acid sequence of SEQ ID NO: 5 and fragments thereof, are provided. The present invention further extends to peptides that include one, two, or several amino acid insertions, substitutions or additions to the aforementioned peptides or fragments, provided they retain cytotoxic T cell inducibility. Also provided as nucleic acids encoding any of the aforementioned peptides, antigen-presenting cells and isolated CTLs that target such peptides, and pharmaceutical agents and compositions including any of the aforementioned peptides, nucleic acids, and APCs as active ingredients. The components of the present invention have particular utility in connection with the treatment and/or prophylaxis (i.e., prevention) of cancers (tumors), and/or the prevention of a postoperative recurrence thereof.

    摘要翻译： 本文描述了针对癌症的肽疫苗。 特别地，提供了衍生自结合HLA抗原并具有细胞毒性T淋巴细胞（CTL）诱导能力的MYBL2基因的表位肽，更特别是具有SEQ ID NO：5的氨基酸序列及其片段的肽。 本发明进一步扩展到包括前述肽或片段的一个，两个或几个氨基酸插入，取代或添加的肽，条件是它们保留细胞毒性T细胞诱导性。 还提供了编码任何上述肽，抗原呈递细胞和靶向这些肽的分离的CTL的核酸以及包含任何上述肽，核酸和APC作为活性成分的药物和组合物的核酸。 本发明的组分与癌症（肿瘤）的治疗和/或预防（即预防）和/或预防其术后复发有关。

    Optical information recording apparatus, optical information recording method, optical information recording/reproducing apparatus and optical information recording/reproducing method
    92.
    发明授权
    Optical information recording apparatus, optical information recording method, optical information recording/reproducing apparatus and optical information recording/reproducing method 有权
    光信息记录装置，光信息记录方法，光信息记录/再现装置和光信息记录/再现方法

    公开(公告)号：US08339921B2

    公开(公告)日：2012-12-25

    申请号：US12453538

    申请日：2009-05-14

    申请人： Yusuke Nakamura

    发明人： Yusuke Nakamura

    IPC分类号： G11B7/00

    CPC分类号： G11B20/1426 ,  G11B7/0065 ,  G11B2020/1457 ,  G11B2020/1469 ,  G11B2220/2504

    摘要： An optical information recording/reproducing apparatus using holography comprises a signal generation unit that modulates input data, adds at least one control bit to each group of N bits, performs an NRZI-modulation on the modulated data, determines the at least one control bit such that a digital sum value of the NRZI-modulated data is 0, performs NRZI modulation on the data whose at least one control bit was determined, and rearranges the data to generate 2-dimensional data; a pickup that records the 2-dimensional data in a hologram disc and reproduces the 2-dimensional data from the hologram disc; and a signal processing unit that corrects the 2-dimensional data reproduced by the pickup, performs NRZI-modulation on the 2-dimensional data that has undergone a binarization operation, removes the at least one control bit added during the recording, and demodulates the data according to a modulation rule used during the recording.

    摘要翻译： 使用全息术的光学信息记录/再现装置包括：信号产生单元，其对输入数据进行调制;将至少一个控制位加到每一组N位;对调制数据执行NRZI调制;确定至少一个控制位， NRZI调制数据的数字和值为0，对确定了至少一个控制位的数据执行NRZI调制，并重新排列数据以生成二维数据; 记录全息图盘中的二维数据的拾取器，并再现来自全息图盘的二维数据; 以及信号处理单元，其校正由拾取器再现的2维数据，对经过二值化操作的二维数据执行NRZI调制，去除在记录期间添加的至少一个控制位，并解调数据 根据记录期间使用的调制规则。

    TMEM22 PEPTIDES AND VACCINES INCLUDING THE SAME
    93.
    发明申请
    TMEM22 PEPTIDES AND VACCINES INCLUDING THE SAME 失效
    TMEM22肽和疫苗，包括它们

    公开(公告)号：US20120308591A1

    公开(公告)日：2012-12-06

    申请号：US13515656

    申请日：2010-12-13

    申请人： Yusuke Nakamura ,  Takuya Tsunoda ,  Ryuji Ohsawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe

    发明人： Yusuke Nakamura ,  Takuya Tsunoda ,  Ryuji Ohsawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe

    IPC分类号： A61K39/00 ,  C12N15/12 ,  C12N5/078 ,  C12N1/21 ,  C12N5/10 ,  A61K31/7088 ,  A61P35/00 ,  C12N15/63 ,  C07K7/06 ,  C12N15/85

    CPC分类号： C07K7/06 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/57 ,  C07K14/705

    摘要： Isolated peptides composed of the amino acid sequence of SEQ ID NO: 33 or fragments thereof that bind to HLA antigens and have cytotoxic T lymphocyte (CTL) inducibility and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines are described herein. The present invention further provides peptides that include one, two, or several amino acid insertions, substitutions or additions to the aforementioned peptides or fragments, but yet retain the requisite cytotoxic T cell inducibility. Further provided are nucleic acids encoding any of these aforementioned peptides as well as pharmaceutical agents, substances and compositions including any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical agents, substances and compositions of this invention find particular utility in the treatment of cancers and tumors.

    摘要翻译： 描述了由SEQ ID NO：33的氨基酸序列组成的分离肽或其与HLA抗原结合并具有细胞毒性T淋巴细胞（CTL）诱导性的因此适合用于癌症免疫治疗，特别是癌症疫苗的上下文中的其片段 这里。 本发明进一步提供了肽，其包括前述肽或片段的一个，两个或几个氨基酸插入，取代或添加，但仍保留所需的细胞毒性T细胞诱导性。 还提供了编码任何上述肽的核酸以及包含上述肽或核酸中任何一种的药物，物质和组合物。 本发明的肽，核酸，药物，物质和组合物在癌症和肿瘤的治疗中具有特别的用途。

    IMP-3 OLIGOPEPTIDES AND VACCINES INCLUDING THE SAME
    94.
    发明申请
    IMP-3 OLIGOPEPTIDES AND VACCINES INCLUDING THE SAME 审中-公开
    IMP-3寡核苷酸和疫苗，包括它们

    公开(公告)号：US20120308590A1

    公开(公告)日：2012-12-06

    申请号：US13513120

    申请日：2010-11-30

    申请人： Yasuharu Nishimura ,  Michiko Harao ,  Yusuke Tomita ,  Yusuke Nakamura ,  Takuya Tsunoda

    发明人： Yasuharu Nishimura ,  Michiko Harao ,  Yusuke Tomita ,  Yusuke Nakamura ,  Takuya Tsunoda

    IPC分类号： A61K39/00 ,  C07H21/04 ,  A61K31/7088 ,  A61P35/00 ,  A61K35/14 ,  C07K7/06 ,  C12N5/078

    CPC分类号： A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/57 ,  C07K14/47

    摘要： Oligopeptides having cytotoxic T cell inducibility and suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines are described herein. Notable examples include oligopeptides having the amino acid sequence of SEQ ID NO: 1, 3, 5 or 6, wherein 1, 2, or several amino acids are optionally substituted, deleted, inserted or added so long as they retain the cytotoxic T cell inducibility of the original oligopeptides. Pharmaceutical formulations or “drugs” related to such oligopeptides suitable for treating or preventing cancers or tumors, as well as the post-operative recurrence thereof, are also described.

    摘要翻译： 本文描述了具有细胞毒性T细胞诱导能力并且适用于癌症免疫治疗，尤其是癌症疫苗的背景下的寡肽。 值得注意的实例包括具有SEQ ID NO：1,3,5或6的氨基酸序列的寡肽，其中1,2或几个氨基酸任选被取代，缺失，插入或加入，只要它们保留细胞毒性T细胞诱导性即可 的原始寡肽。 还描述了与适用于治疗或预防癌症或肿瘤的这种寡肽相关的药物制剂或药物，以及其术后复发。

    OPTICAL DISK REPRODUCING DEVICE AND PHASE-LOCKED LOOP CIRCUIT
    96.
    发明申请
    OPTICAL DISK REPRODUCING DEVICE AND PHASE-LOCKED LOOP CIRCUIT 审中-公开
    光盘再现设备和相位锁定环路

    公开(公告)号：US20120201111A1

    公开(公告)日：2012-08-09

    申请号：US13447975

    申请日：2012-04-16

    申请人： Yusuke Nakamura ,  Masakazu Ikeda ,  Koichiro Nishimura

    发明人： Yusuke Nakamura ,  Masakazu Ikeda ,  Koichiro Nishimura

    IPC分类号： G11B27/36 ,  G11B7/00

    CPC分类号： G11B20/10009 ,  G11B20/10037 ,  G11B20/10046 ,  G11B20/10222 ,  G11B20/10425 ,  G11B20/14 ,  G11B20/22 ,  G11B2220/2537

    摘要： An optical disk reproducing device for controlling false detection of synchronization signals due to intersymbol interference, and stably improving accuracy of frequency acquisition of a phase locked loop (PLL) even when offset and so on occur. A signal width close to an original mark length is obtained to use for frequency acquisition of the PLL by, for example, using two different slice thresholds and taking a width between a rising of a result of slicing at one threshold and a falling of a result of slicing at the other threshold as a synchronization signal width. When asymmetric properties due to offset, asymmetry, etc. occur, an amount of corrections on the slice threshold is calculated, and it is reflected on a threshold previously set to always obtain a correct synchronization signal width.

    摘要翻译： 一种用于控制由于符号间干扰导致的同步信号的错误检测的光盘再现装置，并且即使发生偏移等也能稳定地提高锁相环（PLL）的频率获取的精度。 获得接近原始标记长度的信号宽度，以便通过例如使用两个不同的切片阈值并且在一个阈值的切片结果的上升与结果的下降之间的宽度来使用PLL的频率采集 在另一阈值处切片为同步信号宽度。 当发生由于偏移，不对称等引起的不对称性质时，计算切片阈值上的校正量，并将其反映在预先设定为始终获得正确的同步信号宽度的阈值上。

    OPTICAL INFORMATION RECORDING APPARATUS, OPTICAL INFORMATION RECORDING METHOD, OPTICAL INFORMATION REPRODUCING APPARATUS AND OPTICAL INFORMATION REPRODUCING METHOD
    98.
    发明申请
    OPTICAL INFORMATION RECORDING APPARATUS, OPTICAL INFORMATION RECORDING METHOD, OPTICAL INFORMATION REPRODUCING APPARATUS AND OPTICAL INFORMATION REPRODUCING METHOD 有权
    光信息记录装置，光信息记录方法，光信息再现装置和光信息再现方法

    公开(公告)号：US20120176880A1

    公开(公告)日：2012-07-12

    申请号：US13424480

    申请日：2012-03-20

    申请人： Yusuke Nakamura

    发明人： Yusuke Nakamura

    IPC分类号： G11B7/127 ,  G11B7/1374

    CPC分类号： G11B7/1374 ,  G11B7/0065 ,  G11B7/128

    摘要： An optical information recording/reproducing apparatus and an optical information recording/reproducing method that record information using holography, wherein the optical information recording/reproducing apparatus includes a signal generation unit that generates two-dimensional data by a two-dimensional encoding method in which a lower-limit value of a number of continuous ON/OFF pixels in an array in one direction of pixels in a two-dimensional spatial light modulator is K(K≧2, K: natural number); and a pickup that records the two-dimensional data, generated by the signal generation unit, on a hologram disc.

    摘要翻译： 一种使用全息记录信息的光学信息记录/再现装置和光学信息记录/再现方法，其中光学信息记录/再现装置包括：信号生成单元，其通过二维编码方法生成二维数据，其中 二维空间光调制器中的一个像素方向的阵列中连续的ON / OFF像素的数量的下限值为K（K≥2，K：自然数）; 以及将由信号生成单元生成的二维数据记录在全息图盘上的拾取器。

    Optical information recording method and apparatus
    99.
    发明授权
    Optical information recording method and apparatus 有权
    光信息记录方法和装置

    公开(公告)号：US08174951B2

    公开(公告)日：2012-05-08

    申请号：US12625633

    申请日：2009-11-25

    申请人： Yutaka Nagai ,  Yusuke Nakamura

    发明人： Yutaka Nagai ,  Yusuke Nakamura

    IPC分类号： G11B7/00

    CPC分类号： G11B7/0065 ,  G03H1/182 ,  G11B7/083

    摘要： In a recording apparatus capable of performing a curing process at high speed by curing a plurality of books at a time during recording and capable of performing recording of a recordable type, when recording is stopped once, the unit of books to be cured at a time is set smaller than that during continuous recording, in order to realize inexpensively both performing a curing process at high speed in hologram recording and realizing recording of a recordable type freely in a book unit. It is therefore possible to terminate recording in the unit of arbitrary books irrespective of the unit of books to be cured, and perform recording of a recordable type without loss.

    摘要翻译： 在能够通过在记录期间固化多本书并且能够执行可记录类型的记录来高速执行固化处理的记录装置中，当一次停止记录时，一次要固化的书籍单位 设定为小于连续记录时的设定，以便廉价地实现在全息记录中高速地进行固化处理，并在书本单元中实现可记录型的记录。 因此，可以以任意书籍为单位终止记录，而不管要修复的书籍单位如何，并且不损失地执行可记录类型的记录。