Methods and kits for treating fractures with a biological agent
    93.
    发明授权
    Methods and kits for treating fractures with a biological agent 有权
    用生物制剂治疗骨折的方法和试剂盒

    公开(公告)号:US08147495B2

    公开(公告)日:2012-04-03

    申请号:US11623605

    申请日:2007-01-16

    申请人: William F. McKay

    发明人: William F. McKay

    IPC分类号: A61F2/46

    摘要: A method and kit for treating fractures in a subject entailing placing a temporary fixation device containing a wire in a percutaneous manner across a fracture line, drilling across the fracture line and delivering a biological agent. The biological device is delivered through an injection device which may be the same as the drilling device or different therefrom. The biological agent is delivered uniformly across the complete fractured bone and to the contralateral surface of the fractured bone through an injection device. The method may comprise additional steps of sliding a cannula over the fixation device and affixing the cannula to an outer surface of the fracture. In this embodiment, the drilling device, and later the injection device are placed within the cannula.

    摘要翻译: 一种用于治疗受试者中的骨折的方法和试剂盒,其需要将经皮穿过线材的临时固定装置放置在断裂线上,穿过断裂线穿过并递送生物试剂。 生物装置通过可与钻井装置相同或不同的注射装置输送。 通过注射装置将生物制剂均匀地输送穿过完全断裂的骨和骨折骨的对侧表面。 该方法可以包括将套管滑动到固定装置上并将套管固定到骨折的外表面的附加步骤。 在该实施例中,钻探装置和稍后的注射装置被放置在套管内。

    BONE REPLACEMENT MATERIAL MIXING AND DELIVERY DEVICES AND METHODS OF USE
    94.
    发明申请
    BONE REPLACEMENT MATERIAL MIXING AND DELIVERY DEVICES AND METHODS OF USE 有权
    骨替代材料混合和递送装置及其使用方法

    公开(公告)号:US20110308665A1

    公开(公告)日:2011-12-22

    申请号:US12818300

    申请日:2010-06-18

    申请人: William F. McKay

    发明人: William F. McKay

    IPC分类号: B65B3/04

    CPC分类号: A61B17/8833 A61B2017/8838

    摘要: Bone cement mixing and delivery devices and methods of using the devices are provided. The bone cement mixing and delivery devices and methods comprise a container having a bottom opening that can be sealed by a spacer in a syringe where movement of the plunger of the syringe moves the spacer away from the bottom opening in the container to dispense bone cement into the syringe. In some embodiments, the devices and methods increases efficiency and reduce the mess associated with transferring the bone cement to the syringe for delivery to a patient.

    摘要翻译: 提供了骨水泥混合输送装置及其使用方法。 骨水泥混合和递送装置和方法包括具有底部开口的容器,该底部开口可以通过注射器中的间隔件密封,其中注射器的柱塞的移动使垫片远离容器中的底部开口移动以将骨水泥分配到 注射器。 在一些实施例中,装置和方法提高了效率并减少了将骨粘固剂转移到注射器以用于递送给患者的混乱。

    OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT
    95.
    发明申请
    OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT 有权
    含有着色剂的组合物

    公开(公告)号:US20110286939A1

    公开(公告)日:2011-11-24

    申请号:US13195343

    申请日:2011-08-01

    申请人: William F. McKay

    发明人: William F. McKay

    IPC分类号: A61K38/18 A61P19/00 A61K9/00

    摘要: An osteogenic composition is provided for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the coloring agent imparts color to the growth factor to allow the user to see the growth factor at or near the target tissue site. In some embodiments, a method is provided for accelerating bone repair, the method comprising mixing bone morphogenic protein-2 and a coloring agent to form a mixture; applying the mixture to a surface of a porous collagen matrix, wherein the coloring agent allows the user to see bone morphogenic protein-2 distribution on or in the porous collagen matrix; and implanting the porous collagen matrix at or near a target tissue site in need of bone repair.

    摘要翻译: 提供成骨组合物用于在皮肤下方的靶组织部位处或附近植入,所述成骨组合物包含生长因子和着色剂,其中着色剂向生长因子赋予颜色以允许使用者观察生长因子 或靠近目标组织部位。 在一些实施方案中,提供了一种用于加速骨修复的方法,所述方法包括将骨形态发生蛋白-2和着色剂混合以形成混合物; 将所述混合物施用到多孔胶原基质的表面,其中所述着色剂允许使用者在多孔胶原基质上或其中观察到骨形态发生蛋白-2分布; 以及在需要骨修复的靶组织部位处或附近植入多孔胶原基质。

    RESORBABLE MATRIX HAVING ELONGATED PARTICLES
    96.
    发明申请
    RESORBABLE MATRIX HAVING ELONGATED PARTICLES 有权
    具有长圆形颗粒的可回收基质

    公开(公告)号:US20110182962A1

    公开(公告)日:2011-07-28

    申请号:US12693770

    申请日:2010-01-26

    申请人: William F. McKay

    发明人: William F. McKay

    IPC分类号: A61F2/00 A61K38/39

    摘要: Compression resistant matrices and methods are provided that have elongated particles embedded therein. The compression resistant matrices provide improved stability and mechanical strength and resists shifting, extrusion and rotation after implantation. In some embodiments, the matrices provided reduce or prevent surface compression of the implantable matrix which will cause unwanted increased amounts of growth factor (e.g., bone morphogenic protein) to leak from the matrix.

    摘要翻译: 提供具有嵌入其中的细长颗粒的抗压基质和方法。 耐压基质提供改进的稳定性和机械强度,并且抵抗植入后的移位,挤出和旋转。 在一些实施方案中,所提供的基质降低或防止可植入基质的表面压缩,这将导致不期望的增加量的生长因子(例如,骨形态发生蛋白)从基质泄漏。

    Devices and methods for delivering medical agents
    97.
    发明授权
    Devices and methods for delivering medical agents 有权
    用于递送医疗药剂的装置和方法

    公开(公告)号:US07850656B2

    公开(公告)日:2010-12-14

    申请号:US11118125

    申请日:2005-04-29

    IPC分类号: A61M5/00

    摘要: Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.

    摘要翻译: 描述了用于将医疗剂递送到患者组织体积(例如脊椎盘的内部空间)内的多个位置的新方法,并且还用于在医疗剂递送期间从其中移除材料以增强输送。 还描述了医疗输送装置,例如构造成便于将医疗药剂区域递送到患者组织的针组件。

    Drug depot implant designs
    100.
    发明授权
    Drug depot implant designs 有权
    药店植入物设计

    公开(公告)号:US07741273B2

    公开(公告)日:2010-06-22

    申请号:US11403733

    申请日:2006-04-13

    申请人: William F. McKay

    发明人: William F. McKay

    摘要: The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.

    摘要翻译: 本发明涉及用于将治疗剂最佳递送给受试者的新的药物储库植入物设计。 本发明提供了一种通过靶向递送一种或多种治疗剂来减轻与神经肌肉或骨骼损伤或炎症相关的疼痛以抑制最终引起急性或慢性疼痛的炎症反应的方法。 药物贮库植入物可以由药物贮库植入物提供,包括治疗剂,其特别设计用于通过促进其植入将其转移到期望的位置,使其从所需组织位置的迁移最小化,并且不破坏正常的关节和软组织移动 。