公开(公告)号：US20080140192A1

公开(公告)日：2008-06-12

申请号：US11947770

申请日：2007-11-29

申请人： Mark Humayun ,  Buddy R. Ratner ,  James Weiland ,  Murat Tunc ,  Xuanhong Cheng

发明人： Mark Humayun ,  Buddy R. Ratner ,  James Weiland ,  Murat Tunc ,  Xuanhong Cheng

IPC分类号： A61F2/16 ,  A61B17/00 ,  A61F2/14 ,  C12Q1/24 ,  A61P41/00 ,  A61F2/18 ,  A61B19/08

CPC分类号： A61L24/001 ,  A61B17/00491 ,  A61F9/007 ,  A61L24/06 ,  C08L33/26

摘要： The present invention relates to thermoresponsive adhesives. The invention further relates to methods for the reversible attachment of retinal implants, other implants, and drug delivery devices.

摘要翻译： 本发明涉及热敏粘合剂。 本发明还涉及视网膜植入物，其它植入物和药物递送装置的可逆附着的方法。

公开(公告)号：US20080064946A1

公开(公告)日：2008-03-13

申请号：US11928151

申请日：2007-10-30

申请人： Robert Greenberg ,  Neil Talbot ,  Jordan Neysmith ,  James Little ,  Brian Mech ,  Mark Humayun ,  Dilek Guven ,  Anne-Marie De Merlier Ripley

发明人： Robert Greenberg ,  Neil Talbot ,  Jordan Neysmith ,  James Little ,  Brian Mech ,  Mark Humayun ,  Dilek Guven ,  Anne-Marie De Merlier Ripley

IPC分类号： A61N1/04

CPC分类号： H05K3/0011 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36036 ,  A61N1/36046 ,  Y10T29/49124

摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

摘要翻译： 聚合物材料可用作用于神经刺激的电极阵列体。 它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。 通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。 由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。 此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。 通过将适量的热应用于完整的阵列，可以引起曲线。 对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。 此外，沿着边缘添加材料是有利的。 在柔性电路阵列中提供折叠或扭曲是更有利的。 可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

公开(公告)号：US20080046032A1

公开(公告)日：2008-02-21

申请号：US11924458

申请日：2007-10-25

申请人： Robert Greenberg ,  Mark Humayun

发明人： Robert Greenberg ,  Mark Humayun

IPC分类号： A61N1/05

CPC分类号： A61N1/0543 ,  A61F9/08 ,  A61N1/36046

摘要： The artificial percept of light may be created by electrically stimulating the neurons of the retina. While a photolithographed array internal to the retina provides superior resolution, an array external to the retina provides easier implantation and improved manufacturability. Therefore it is advantageous to supply a high-resolution electrode array internal to the sclera, near the fovea and a lower-resolution electrode array eternal to the sclera near the periphery of the retina. The preferred method of manufacturing a high-resolution electrode array is through photolithography, which requires the array to be made flat. While it is possible to curve the array afterward, it is difficult and costly. I small high-resolution array can be implanted near the fovea. Due to its small size, curvature is less of an issue. A larger lower-resolution array can be molded in silicone or similar method and placed around the periphery, of the retina, where the retina is naturally lower resolution. Further, the lower-resolution array can be implanted external to the sclera reducing the number of electrical connectors passing through the sclera. Even if a separate lower-resolution array is implanted internal to the sclera, super-choroidal (between the choroid and sclera) or intra-scleral (between the layers of the sclera), it is easier to make a lower-resolution array in a curved shape.

摘要翻译： 光的人造感知可以通过电刺激视网膜的神经元来产生。 虽然在视网膜内部的光刻阵列提供优异的分辨率，但是视网膜外部的阵列提供更容易的植入和改进的可制造性。 因此，在中央凹附近提供巩膜内部的高分辨率电极阵列和靠近视网膜周边的巩膜永久的较低分辨率的电极阵列是有利的。 制造高分辨率电极阵列的优选方法是通过光刻法，其需要使阵列平坦。 虽然以后可以对阵列进行曲线化，但是难度高昂。 我小型高分辨率阵列可以植入中央凹附近。 由于其体积小，曲率较少是一个问题。 更大的较低分辨率阵列可以用硅树脂或类似的方法模制，并且放置在视网膜的周边周围，其中视网膜天然较低的分辨率。 此外，较低分辨率阵列可以植入巩膜外部，从而减少通过巩膜的电连接器的数量。 即使单独的较低分辨率阵列植入巩膜内部，超脉络膜（脉络膜和巩膜之间）或巩膜内（巩膜层之间），则更容易在较低分辨率阵列 弯曲的形状。

公开(公告)号：US07321796B2

公开(公告)日：2008-01-22

申请号：US10837163

申请日：2004-04-30

申请人： Wolfgang Fink ,  Mark Humayun

发明人： Wolfgang Fink ,  Mark Humayun

IPC分类号： A61N1/36

CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/08

摘要： A method for training a visual prosthesis includes presenting a non-visual reference stimulus corresponding to a reference image to a visual prosthesis patient. The visual prosthesis including a plurality of electrodes. Training data sets are generated by presenting a series of stimulation patterns to the patient through the visual prosthesis. Each stimulation pattern in the series, after the first, is determined at least in part on a previous subjective patient selection of a preferred stimulation pattern among stimulation patterns previously presented in the series and a fitness function optimization algorithm. The presented stimulation patterns and the selections of the patient are stored and presented to a neural network off-line to determine a vision solution.

摘要翻译： 用于训练视觉假体的方法包括将对应于参考图像的非视觉参考刺激呈现给视觉假体患者。 视觉假体包括多个电极。 训练数据集是通过将视觉假体呈现给患者的一系列刺激模式而产生的。 系列中的每个刺激模式在第一次之后至少部分地基于先前在该系列中呈现的刺激模式中的优选刺激模式的先前主观患者选择和适应度函数优化算法来确定。 呈现的刺激模式和患者的选择被存储并离线地呈现给神经网络以确定视觉解决方案。

公开(公告)号：US20070123766A1

公开(公告)日：2007-05-31

申请号：US11540087

申请日：2006-09-29

申请人： John Whalen ,  James Weiland ,  Mark Humayun

发明人： John Whalen ,  James Weiland ,  Mark Humayun

IPC分类号： A61B5/04

CPC分类号： A61B5/04001 ,  A61B5/685 ,  A61B2562/0215 ,  A61B2562/0217 ,  A61B2562/125 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/37205 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00

摘要： Microelectrode assemblies and related methods are disclosed for bio-stimulating and/or bio-sensing a target tissue. The assemblies can include a two-side substrate, an array of microelectrodes, each of the microelectrodes including a nano-wire embedded within the substrate and extending from a proximal end to a distal end and through the substrate, each nano-wire having a diameter preferably less than 1 μm. The substrate can include portions made of nano-porous material(s) through which the microelectrodes pass. The substrate with the embedded nano-wires can effectively be fluid impermeable. The proximal ends of the nano-wires can be adapted to be connected to an electronic device and the distal ends are adapted to be disposed in a biological environment for bio-stimulating a target tissue and/or bio-sensing activities of the target tissue. Suitable alloys such as platinum, platinum-iridium, and/or other noble-metal-alloyed compositions can be used for the nano-wires.

摘要翻译： 公开了用于生物刺激和/或生物感测靶组织的微电极组件和相关方法。 组件可以包括两侧基板，微电极阵列，每个微电极包括嵌入基板内的纳米线，并从近端延伸到远端并穿过基板，每个纳米线具有直径 优选小于1um。 基板可以包括由微电极通过的纳米多孔材料制成的部分。 具有嵌入式纳米线的基板可以有效地不透液体。 纳米线的近端可以适于连接到电子设备，并且远端适于设置在用于生物刺激靶组织和/或靶组织的生物感测活动的生物环境中。 合适的合金如铂，铂 - 铱和/或其它贵金属合金组合物可用于纳米线。

公开(公告)号：US20060200097A1

公开(公告)日：2006-09-07

申请号：US10543083

申请日：2004-01-26

申请人： Mark Humayun ,  Eugene De Juan

发明人： Mark Humayun ,  Eugene De Juan

IPC分类号： A61M31/00 ,  A61M37/00

CPC分类号： A61F9/0017 ,  A61F2/16 ,  A61F2250/0068 ,  A61M5/1428 ,  A61M2210/0612

摘要： Featured are devices and methods for administering a therapeutic medium to the posterior segment of an eye including instilling or disposing the therapeutic medium sub-retinally. Such instillation is accomplished by providing a reservoir containing a therapeutic medium to which is fluidly coupled a cannula and inserting a portion of the cannula sub-retinally, whereby the therapeutic medium within the reservoir is coupled to and dispersed subretinally via the cannula.

摘要翻译： 特别是用于将治疗性介质施用于眼后段的装置和方法，包括滴注或处置回顾性治疗介质。 这种滴注是通过提供一种包含治疗介质的储存器来实现的，该治疗介质流体地联接套管并且插入套管的一部分，其中储存器内的治疗介质通过套管联接到并且通过插管被分散地分散。

公开(公告)号：US20060173511A1

公开(公告)日：2006-08-03

申请号：US11293400

申请日：2005-12-01

申请人： Robert Greenberg ,  Mark Humayun

发明人： Robert Greenberg ,  Mark Humayun

IPC分类号： A61N1/32

CPC分类号： A61N1/0543 ,  A61N1/36046

摘要： Present invention is a method of improving circadian rhythms in blind people by stimulation the visual neural system. Ideally a retinal prosthesis of the type used to restore vision can be used to restore normal circadian rhythms. Additionally, brightness on the prosthesis can be increased in the morning and decreased in the evening to stimulate normal Circadian rhythms. Alternatively, if a retinal prosthesis is not preferable, the retina can be stimulated externally, during the day and not at night. While such eternal stimulation can not produced artificial vision, it can stimulate normal circadian rhythms.

摘要翻译： 本发明是通过刺激视觉神经系统来改善盲人中的昼夜节律的方法。 理想地，用于恢复视力的视网膜假体可用于恢复正常的昼夜节律。 此外，假体上的亮度可以在早晨增加并在晚上减少以刺激正常的昼夜节律。 或者，如果视网膜假体不是优选的，则视网膜可以在白天刺激，而不是在夜间刺激。 虽然这种永恒的刺激不能产生人造视觉，但它可以刺激正常的昼夜节律。

公开(公告)号：US20050277802A1

公开(公告)日：2005-12-15

申请号：US11056763

申请日：2005-02-11

申请人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US20050033272A1

公开(公告)日：2005-02-10

申请号：US10934050

申请日：2004-09-04

申请人： Mark Humayun

发明人： Mark Humayun

IPC分类号： A61B19/00 ,  A61F9/007 ,  A61M1/00 ,  A61M13/00 ,  A61B18/18

CPC分类号： A61M1/008 ,  A61B2090/3614 ,  A61B2090/3937 ,  A61F9/007 ,  A61M13/003 ,  A61M2210/0612

摘要： A surgical device having a body portion that is gripped by a user, the body portion having a distal end equipped with a soft tip and the proximal end optionally connected to an external vacuum or gas/air source. The surgical device is particularly suitable for use in ophthalmic surgical procedures to remove fluid from the eye or introduce gas/air into the eye. The soft tip is fabricated to protect the delicate tissues if the eye and is further modified so as to enhance a user's visibility of the device in the surgical field.

摘要翻译： 一种手术装置，其具有被使用者抓握的主体部分，所述主体部分具有配备有软尖端的远端，并且所述近端可选地连接到外部真空或气体/空气源。 手术装置特别适合用于眼科外科手术以从眼睛中除去流体或将气体/空气引入眼睛。 制造软尖端以保护精细的组织，如果眼睛被进一步修改以增强使用者在手术领域中的装置的可视性。

公开(公告)号：US10390856B2

公开(公告)日：2019-08-27

申请号：US13351836

申请日：2012-01-17

申请人： Michelle Journey ,  Sean Caffey ,  Mark Humayun ,  John Huculak

发明人： Michelle Journey ,  Sean Caffey ,  Mark Humayun ,  John Huculak

IPC分类号： A61B17/28 ,  A61B17/30 ,  A61B17/00 ,  A61B17/29 ,  A61F9/00 ,  A61F13/51

摘要： Surgical introducers aid surgeons in the implantation of medical devices. The introducer provides support and an even distribution of force for ease of insertion and prevention of damage to the medical device while protecting the tissue into which the device is implanted. A representative embodiment includes or consists of a locking device, a pair of forceps, a specially configured and/or angled head with a seat for the device to be implanted, and a gripping area.