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公开(公告)号：US20240342204A1
公开(公告)日：2024-10-17
申请号：US18294592
申请日：2022-08-05
申请人： Intervet Inc.
IPC分类号： A61K31/7068 , A61P31/14 , A61P31/16 , A61P37/04
CPC分类号： A61K31/7068 , A61P31/14 , A61P31/16 , A61P37/04
摘要： A method of preventing or treating a viral disease in an animal comprising administering to the animal a pharmaceutical composition comprising an antiviral nucleoside β-D-N(4)-hydroxycytidine (NHC) or a prodrug or salt thereof and a pharmaceutically acceptable carrier and wherein the viral disease is Porcine Reproductive and Respiratory Syndrome (PRRS), Bovine Respiratory Disease (BRD), Equine Influenza, Canine Distemper, Canine Respiratory Disease, Feline Infectious Peritonitis, Feline Viral Rhinotracheitis, or Feline Immunodeficiency.
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公开(公告)号：US20240325514A1
公开(公告)日：2024-10-03
申请号：US18293380
申请日：2022-06-29
申请人： Intervet Inc.
CPC分类号： A61K39/092 , A61P37/04 , A61K2039/552
摘要： The present invention pertains to a vaccine for protection against a pathogenic infection with Streptococcus suis, the vaccine comprising a whole IgM protease antigen of Streptococcus suis, the antigen comprising in its amino acid sequence less than four repeats, and a pharmaceutically acceptable carrier. The invention also pertains to this antigen for use in a method to protect a pig against such an infection, and to a method to protect such a pig.
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![Method for racemisation of (5R)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H¬isoxazol-3-yl]-2-methyl-benzoic acid](/abs-image/US/2024/09/03/US12077514B2/abs.jpg.150x150.jpg)
公开(公告)号：US12077514B2
公开(公告)日：2024-09-03
申请号：US17414214
申请日：2019-12-20
申请人： Intervet Inc.
发明人： Harald Schmitt
IPC分类号： C07D261/04 , C07B55/00
CPC分类号： C07D261/04 , C07B55/00
摘要： The present invention relates to a method for racemizing (5R)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid.
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公开(公告)号：US12023374B2
公开(公告)日：2024-07-02
申请号：US17294706
申请日：2019-11-22
申请人： Intervet Inc.
CPC分类号： A61K39/12 , A61K2039/545 , A61K2039/55
摘要： The present invention pertains to a vaccine comprising an IgM protease antigen of Streptococcus suis, for use in a method for protecting a pig against Streptococcus suis, characterised in that the IgM protease antigen is a protein according to SEQ ID NO:1.
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公开(公告)号：US20240197851A1
公开(公告)日：2024-06-20
申请号：US17909917
申请日：2021-03-12
申请人： Intervet Inc.
CPC分类号： A61K39/092 , A61P31/04 , A61P37/04 , A61K2039/552 , A61K2039/70
摘要： The present invention pertains to a vaccine comprising in combination an IgM protease antigen of Streptococcus suis and a Streptococcus suis bacterin of serotype (9), sequence type (16), for use in a method for protecting pigs against a pathogenic infection with Streptococcus suis serotype (9), sequence type (16).
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公开(公告)号：US20240115685A1
公开(公告)日：2024-04-11
申请号：US18257409
申请日：2021-12-21
申请人： INTERVET INC.
CPC分类号： A61K39/0013 , A61P39/00 , A61K2039/552 , A61K2039/55566 , A61K2039/6081
摘要： The present invention pertains to the use of conjugated fumonisin (FUM) in a method to protect an animal against FUM induced mycotoxicosis, in particular to protect against a decrease in average daily weight gain, intestinal damage, liver damage and kidney damage as a result of the ingestion of FUM.
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公开(公告)号：US20240058366A1
公开(公告)日：2024-02-22
申请号：US18257815
申请日：2021-12-23
申请人： Intervet Inc.
发明人： Ralf Warrass , Joachim Ullrich
IPC分类号： A61K31/7048 , A61P31/04 , A61K45/06 , A61K9/00
CPC分类号： A61K31/7048 , A61P31/04 , A61K45/06 , A61K9/0041
摘要： This invention relates to methods of treatment and prevention of mastitis in animals by orthosomycin antimicrobial compounds.
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公开(公告)号：US20240024496A1
公开(公告)日：2024-01-25
申请号：US18257415
申请日：2021-12-21
申请人： INTERVET INC.
IPC分类号： A61K47/64 , A61K31/365 , A61P31/10
CPC分类号： A61K47/646 , A61K47/643 , A61K31/365 , A61P31/10 , A61K2039/552
摘要： The present invention pertains to the use of conjugated zearalenone (ZEA) in a method to protect an animal against ZEA induced mycotoxicosis, in particular to protect against decreased weight gain, kidney damage, liver damage and damage to a reproductive organ.
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公开(公告)号：US20240024456A1
公开(公告)日：2024-01-25
申请号：US18043944
申请日：2021-09-06
申请人： Intervet Inc.
IPC分类号： A61K39/145 , C07K14/11 , C12N15/86 , A61P31/16
CPC分类号： A61K39/145 , C07K14/11 , C12N15/86 , A61P31/16
摘要： The present invention relates to vaccines against influenza virus infection or disease for targets with pre-existing antibodies against influenza virus HA head domain. The invention regards a recombinant vector expressing a HA stem polypeptide, a vaccine comprising the vector or a host cell with said vector, uses of the vector, the host cell, or the vaccine, and methods for reducing influenza virus infection or disease. The recombinant vector can be a nucleic acid such as a eukaryotic expression plasmid or an RNA, a virus, or a replicon particle (RP). This vaccination allows for the induction of an early- and effective immune-response against Influenza virus induced infection or disease, not hindered by pre-existing anti-HA head domain antibodies.
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公开(公告)号：US20240000920A1
公开(公告)日：2024-01-04
申请号：US18252624
申请日：2021-11-11
申请人： Intervet Inc.
IPC分类号： A61K39/215 , C12N15/86 , C07K14/005 , A61P31/14
CPC分类号： A61K39/215 , C12N15/86 , C07K14/005 , A61P31/14 , C12N2770/20022 , C12N2770/20034 , C12N2770/20071 , C12N2770/36143 , C07K2319/50 , C07K2319/35 , C07K2319/03 , A61K2039/5256
摘要： The present invention provides recombinant vectors encoding a chimeric coronavirus spike protein. The present invention further provides new immunogenic compositions and vaccines comprising these recombinant vectors. Methods of administering these immunogenic compositions and vaccines to animal subjects, including humans, felines, and avians, to protect them against coronaviruses also are included. Methods of making the immunogenic compositions and vaccines alone or in combinations with other protective agents are provided too.
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