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    Cephalosporin derivatives
    91.
    发明授权
    Cephalosporin derivatives 失效
    头孢菌素衍生物

    公开(公告)号：US4034090A

    公开(公告)日：1977-07-05

    申请号：US592096

    申请日：1975-06-30

    申请人： Christian Berger ,  Daniel Farge ,  Georges Gros ,  Mayer Naoum Messer ,  Claude Moutonnier

    发明人： Christian Berger ,  Daniel Farge ,  Georges Gros ,  Mayer Naoum Messer ,  Claude Moutonnier

    IPC分类号： C07D501/06 ,  A61K31/546 ,  C07D257/04 ,  C07D285/12 ,  C07D285/125 ,  C07D285/13 ,  C07D501/20 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  A61K31/545

    CPC分类号： C07D257/04 ,  C07C329/00 ,  C07D285/125 ,  C07D285/13 ,  C07D501/20

    摘要： New cephalosporin derivatives of the formula: ##STR1## in which either (a) R.sub.1 is hydrogen, acetoxy, azido or heterocyclylthio or heterocyclylcarbonylthio which is (1,3,4-thiadiazol-2-yl)-thio which is unsubstituted or substituted by straight or branched chain C.sub.1-4 alkyl or alkoxy, straight or branched chain C.sub.1-4 alkylthio, straight or branched chain C.sub.1-4 alkylsulphonyl, amino or acetylamino; (1,2,3,4-tetrazol-5-yl)-thio which is unsubstituted or substituted in the 1-position by straight or branched chain C.sub.1-4 alkyl, hydroxy straight or branched chain C.sub.1-4 alkyl, phenyl or hydroxyphenyl, or in the 2-position by straight or branched chain C.sub.1-4 alkyl or hydroxy straight or branched chain C.sub.1-4 alkyl; (1,2,4-triazol-3-yl)-thio, (4-methyl-1,3-thiazol-2-yl)-thio, (3-methyl-1,2,4-thiadiazol-5-yl)-thio or (1,2,3-thiadiazol-4-yl)-carbonylthio, and R.sub.2 is carboxy or a radical of the formula: ##STR2## in which the radical: ##STR3## is a radical which can be easily removed enzymatically, and in which R.sub.3 is hydrogen or straight or branched chain C.sub.1-4 alkyl and R.sub.4 is straight or branched chain C.sub.1-4 alkyl or cyclohexyl; or (b) R.sub.1 is a pyridinio ion and R.sub.2 is a carboxylato ion, and pharmaceutically acceptable non-toxic metal salts thereof and addition salts thereof with nitrogen containing bases possess valuable anti-bacterial properties, showing activity against both Gram-positive and Gram-negative bacteria.

    摘要翻译： 下式的新型头孢菌素衍生物：其中（a）R 1是氢，乙酰氧基，叠氮基或杂环基硫基或杂环基羰基硫基，其是未取代的（1,3,4-噻二唑-2-基） - 硫基 直链或支链C 1-4烷基或烷氧基，直链或支链C 1-4烷硫基，直链或支链C 1-4烷基磺酰基，氨基或乙酰氨基; （1,2,3,4-四唑-5-基） - 硫基，其未被取代或在1-位被直链或支链C 1-4烷基取代，羟基直链或支链C 1-4烷基，苯基或羟基苯基 或2-位的直链或支链C 1-4烷基或羟基直链或支链C 1-4烷基; （1,2,4-三唑-3-基） - 硫代，（4-甲基-1,3-噻唑-2-基） - 硫代，（3-甲基-1,2,4-噻二唑-5-基） ） - 硫代或（1,2,3-噻二唑-4-基） - 羰基硫基，并且R 2是羧基或下式的基团：其中基团：（III）是 其可以容易地被酶除去，其中R 3是氢或直链或支链C 1-4烷基，R 4是直链或支链C 1-4烷基或环己基; 或（b）R 1是吡啶鎓离子，R 2是羧基离子，其药学上可接受的无毒金属盐和其与含氮碱基的加成盐具有有价值的抗菌性质，显示出对革兰氏阳性和革兰氏阴性菌的活性， 阴性细菌。

    Bioresorbable surgical articles
    92.
    发明授权
    Bioresorbable surgical articles 失效
    生物可吸收外科用品

    公开(公告)号：US4032993A

    公开(公告)日：1977-07-05

    申请号：US590284

    申请日：1975-06-25

    申请人： Jean Coquard ,  Pierre Sedivy ,  Michel Ruaud ,  Jean Verrier

    发明人： Jean Coquard ,  Pierre Sedivy ,  Michel Ruaud ,  Jean Verrier

    IPC分类号： A61L17/00 ,  A61L17/10 ,  A61L17/12 ,  A61L27/18 ,  A61L27/58 ,  C08G63/12 ,  D01F6/84 ,  A61F1/24 ,  A61F1/00

    CPC分类号： A61L27/58 ,  A61L17/105 ,  A61L17/12 ,  A61L27/18

    摘要： Implantable surgical articles are provided which are at least partially bioresorbable and which consist at least partially of a copolyester of succinic acid and oxalic acid possessing receiving units of the general formulae: ##STR1## in which each R radical in the chain, which may be identical or different, represents a linear or branched alkylene radical possessing 2 to 6 carbon atoms, at least 2 of which carbon atoms form part of the polymer chain, a cyclo-alkylene radical possessing 5 to 8 carbon atoms, or a radical of the general formula: ##STR2## in which each of R.sub.1 and R.sub.2, which may be identical or different, represents a methylene or ethylene radical. They are particularly suitable as sutures.

    摘要翻译： 提供了至少部分可生物再吸收并且至少部分由琥珀酸和草酸的共聚酯组成的可植入手术制品，其具有以下通式的接收单元：其中每个 可以相同或不同的链中的R基团表示具有2-6个碳原子的直链或支链亚烷基，其中至少2个碳原子形成聚合物链的一部分，环 - 亚烷基具有5至8个 碳原子或以下通式的基团：其中R 1和R 2各自可以相同或不同，表示亚甲基或亚乙基。 它们特别适合作为缝线。

    1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and compositions containing them
    93.
    发明授权
    1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and compositions containing them 失效
    1,4-二硫辛（和氧硫辛酸） - 基头孢菌素衍生物和含有它们的组合物

    公开(公告)号：US4029781A

    公开(公告)日：1977-06-14

    申请号：US617066

    申请日：1975-09-26

    申请人： Christian Berger ,  Daniel Farge ,  Georges Gros ,  Mayer Naoum Messer ,  Claude Moutonnier

    发明人： Christian Berger ,  Daniel Farge ,  Georges Gros ,  Mayer Naoum Messer ,  Claude Moutonnier

    IPC分类号： C07D501/22 ,  A61K31/546 ,  C03C17/28 ,  C07D501/06 ,  C07D501/20 ,  C07D501/34 ,  A61K31/54

    CPC分类号： C07D501/20 ,  C03C17/28 ,  Y02P20/55

    摘要： New cephalosporin compounds of the formula: ##STR1## in which A is oxygen or sulphur, R.sub.1 is hydrogen or acetoxy and R.sub.2 is carboxy or a radical of the formula: ##STR2## in which the radical ##STR3## is a radical which can be easily removed enzymatically, and in which R.sub.3 is hydrogen or straight or branched chain C.sub.1-4 alkyl and R.sub.4 is straight or branched chain C.sub.1-4, alkyl or cyclohexyl, together with its diastereoisomeric forms and mixtures thereof, its acid addition salts and, where appropriate, its pharmaceutically acceptable non-toxic metal salts and addition salts with nitrogen-containing bases other than ammonia, exhibit valuable anti-bacterial properties, in particular against Gram-positive and Gram-negative bacteria.

    摘要翻译： 下式的新型头孢菌素化合物：其中A是氧或硫，R1是氢或乙酰氧基，R2是羧基或下式的基团：其中基团（I） （III）是可以容易地酶促去除的基团，其中R3是氢或直链或支链C1-4烷基，R4是直链或支链C1-4，烷基或环己基，以及它们的非对映异构形式和混合物 其酸加成盐，并且在适当的情况下，其药学上可接受的无毒金属盐和与氨以外的含氮碱的加成盐显示出有价值的抗菌性质，特别是抗革兰氏阳性和革兰氏阴性菌。

    1,4-Oxathiino[2,3-c]pyrrole derivatives
    95.
    发明授权
    1,4-Oxathiino[2,3-c]pyrrole derivatives 失效
    1,4-oxathiino {8,2,3- C {9吡咯衍生物

    公开(公告)号：US4021554A

    公开(公告)日：1977-05-03

    申请号：US628927

    申请日：1975-11-05

    申请人： Claude Cotrel ,  Claude Jeanmart ,  Michel Barreau

    发明人： Claude Cotrel ,  Claude Jeanmart ,  Michel Barreau

    IPC分类号： C07D515/04 ,  A61K31/40 ,  A61K31/435 ,  A61K31/495 ,  A61K31/496 ,  A61K31/50 ,  A61P25/08 ,  A61P25/20 ,  C07D215/38 ,  C07D241/04 ,  C07D327/00 ,  C07D497/04 ,  C07D519/00 ,  C07D411/14

    CPC分类号： C07D215/38 ,  C07D497/04

    摘要： 1,4-Oxathiino[2,3-c]pyrrole derivatives of the formula: ##STR1## wherein A represents a phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals selected from halogen, alkyl of 1 through 4 carbon atoms, alkoxy of 1 through 4 carbon atoms and nitro, and R represents alkyl of 1 through 4 carbon atoms, cycloalkyl of 3 through 6 carbon atoms, alkenyl of 2 through 4 carbon atoms or alkynyl of 2 through 4 carbon atoms, possess pharmacological properties, and are especially useful as tranquillizers, anti-convulsant agents, decontracturants, and agents to produce hypnosis.

    摘要翻译： 其中A代表苯基，2-吡啶基，3-哒嗪基，2-喹啉基或萘啶基，或被一个或多个取代基取代的所述基团取代的下式的1,4-氧硫杂环丁烷并[2,3-c] 选自卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基和硝基的两个原子或基团，R表示1至4个碳原子的烷基，3至6个碳原子的环烷基，2至4的烯基 具有2至4个碳原子的碳原子或炔基具有药理学性质，并且特别可用作镇静剂，抗惊厥剂，脱保护剂和产生催眠剂的试剂。

    Organosilicon compositions which impart non-stick properties to cellulosic and synthetic materials
    97.
    发明授权
    Organosilicon compositions which impart non-stick properties to cellulosic and synthetic materials 失效
    对纤维素和合成材料赋予不粘性的有机硅组合物

    公开(公告)号：US4018734A

    公开(公告)日：1977-04-19

    申请号：US584353

    申请日：1975-06-06

    申请人： Jean Dumoulin

    发明人： Jean Dumoulin

    IPC分类号： C08J7/04 ,  C08K5/5435 ,  C08L83/00 ,  C08L83/04 ,  C10M111/04 ,  C10N20/02 ,  C10N40/36 ,  D21H19/32 ,  C08K5/00 ,  C08K5/01 ,  C08K5/07 ,  C08K5/10

    CPC分类号： C08J7/047 ,  C08L83/04 ,  D21H19/32 ,  C08G77/045 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08J2483/00 ,  Y10T428/31663

    摘要： Organosilicon compositions which impart good and immediate non-stick properties to cellulosic and synthetic materials are provided comprising a mixture of dimethylpolysiloxane polymer, a catalyst, an epoxy silane, a crosslinking system and organic solvent, the crosslinking system comprising 70 to 95% of at least one organosilicon compound possessing at least 3 acyloxy groups bonded to one or more silicon atoms, which is a silane of the formula RSi(OCOR").sub.3, a disilane, a disiloxane or a disilylalkane of the formula (R"COO).sub.3.sub.-d.sub.' R.sub.d.sub.' Si(X).sub.f SiR.sub.d (OCOR").sub.3.sub.-d, in which R and R" are as defined above, X represents an oxygen atom or the alkylene radical --(CH.sub.2).sub.h --, each of d and d', which may be identical or different, represents zero, 1 or 2, the sum d + d' being 2 or 3, f represents zero or 1 and h represents 2 or 4, and 2) 5 to 30% of at least one hexaalkoxymethylmelamine, the alkoxy groups each having 1 to 4 carbon atoms.

    摘要翻译： 提供了赋予纤维素和合成材料良好且立即不粘性的有机硅组合物，其包含二甲基聚硅氧烷聚合物，催化剂，环氧硅烷，交联体系和有机溶剂的混合物，交联体系至少包含70-95％ 一种具有至少3个与一个或多个硅原子键合的酰氧基的有机硅化合物，其是式RSi（OCOR“）3的硅烷，式（R''COO）3的乙硅烷，二硅氧烷或二硅烷基烷烃 d'Rd'Si（X）fSiRd（OCOR“）3-d，其中R和R”如上所定义，X表示氧原子或亚烷基 - （CH 2）h - ，每个d 和d'可以相同或不同，表示0,1或2，总和d + d'为2或3，f表示0或1，h表示2或4，2）5至30％的 至少一个六烷氧基甲基三聚氰胺，各自具有1至4个碳原子的烷氧基。

    Aqueous compositions of polyimides containing hetero-polysaccharide
    98.
    发明授权
    Aqueous compositions of polyimides containing hetero-polysaccharide 失效
    含有异多糖的聚酰亚胺的含水组合物

    公开(公告)号：US4013600A

    公开(公告)日：1977-03-22

    申请号：US578025

    申请日：1975-05-16

    申请人： Robert Cassat

    发明人： Robert Cassat

    IPC分类号： C08G73/00 ,  C08G73/12 ,  C08J3/02 ,  C08J3/05 ,  C08J5/24 ,  C08L79/08 ,  C08L5/00

    CPC分类号： C08J5/24 ,  C08J3/05 ,  C08L79/085 ,  C08J2379/08 ,  Y10T428/24149

    摘要： Pseudoplastic aqueous suspensions are provided having good storage stability. These suspensions are of a prepolymer powder prepared fromA. a imide group-containing compound chosen from the group consisting of:A. a bis-imide of the formula: ##STR1## in which D represents a divalent radical which has the formula: ##STR2## wherein Y represents H, CH.sub.3 or Cl and m is equal to 0 or 1, and A represents a divalent organic radical containing 2 to 30 carbon atoms, andB. a mixture of a bis-imide of formula (I) and a mono-imide of the formula: ##STR3## in which D is as defined above and R represents a hydrogen atom or a monovalent organic radical containing 1 to 20 carbon atoms, andB. an amino compound chosen from the group consisting of:A. one or more polyamines containing 2 to 5 primary or secondary amino groups, at least one of these groups being primary,B. a mixture comprising one or more polyamines as defined under a) and one or more primary and/or secondary monoamines and/or one or more secondary polyamines, andC. a polyamine of the general formula: ##STR4## in which x represents a number from 0.1 to 2 and R' represents a divalent hydrocarbon radical with 1 to 8 carbon atoms,The suspension also comprising, based on the weight of the powder, 0.01 to 8% by weight of a heteropolysaccharide of very high molecular weight.

    摘要翻译： 提供了具有良好储存稳定性的假塑性水性悬浮液。 这些悬浮液是由A.制备的预聚物粉末。含酰亚胺基化合物选自：

    Method of obtaining a micro-porous membrane and novel product thus obtained
    99.
    发明授权
    Method of obtaining a micro-porous membrane and novel product thus obtained 失效
    获得微孔膜的方法和由此获得的新产品

    公开(公告)号：US4003818A

    公开(公告)日：1977-01-18

    申请号：US600219

    申请日：1975-07-31

    申请人： Michel Juillard ,  Pierre Bouy

    发明人： Michel Juillard ,  Pierre Bouy

    IPC分类号： C08J9/26 ,  C25B13/08 ,  F16J3/02 ,  B29D27/08

    CPC分类号： C25B13/08

    摘要： A method of obtaining a micro-porous membrane is provided as well as the improved membrane. Said method is characterized in that a homogeneous paste is prepared from a pore-forming filler substance and a latex, and said paste, which is reduced to powder form, is dried and a membrane is formed therefrom and then (fritted) sintered, and the pore-forming filler substance is then removed. The membrane thus obtained is particularly useful as a diaphragm for electrolysis cells.

    摘要翻译： 提供了获得微孔膜的方法以及改进的膜。 所述方法的特征在于，从成孔填料和胶乳制备均匀的糊状物，将所述还原成粉末的糊状物干燥，并由其形成膜，然后（烧结）烧结， 然后除去成孔填料。 由此得到的膜特别适用于电解槽的隔膜。