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    ANTI-BIOFILM COMPOUNDS
    91.
    发明申请
    ANTI-BIOFILM COMPOUNDS 有权
    抗生素化合物

    公开(公告)号：US20140161845A1

    公开(公告)日：2014-06-12

    申请号：US14234343

    申请日：2012-07-20

    申请人： Donald R. Demuth ,  Frederick A. Luzzio

    发明人： Donald R. Demuth ,  Frederick A. Luzzio

    IPC分类号： C07D413/14 ,  A01N43/76

    CPC分类号： A01N43/76 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14

    摘要： The present invention provides non-peptide compounds of formula (I) wherein: X is —(C1-C8)allcyl-, aryl or -aryl(C1-C8)alkyl-; Y is —(C1-C8)alkyl- or absent; W is heteroaryl, (C3-C7)carbocycle or aryl, wherein any heteroaryl, (C3-C7)carbocycle or, aryl of W is optionally substituted with one or more (e.g. 1, 2, 3, 4 or 5) Z1 groups; R1 is (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl or aryl, wherein aryl is optionally substituted with one or more (e.g. 1, 2, 3, 4 or 5) groups selected from (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, halo(C1-C3)alkyl, —CN, NO2, halogen, —ORa, —SRa, —S(O)2NRbRc, —NRbRc, —NRaCORd, —C(O)Ra, —C(O)ORa, and —C(O)NRbRc; R2 is (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)Jalkynyl or aryl, wherein aryl is optionally substituted with one or more (e.g. 1, 2, 3, 4 or 5) groups selected from (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, halo(C1-C3)alkyl, —CN, NO2, halogen, —ORe, —SRe, —S(O)2NRfRg, —NRfRg—NReCORh, —C(O)Re, —C(O)ORe and —C(O)NRfRg; I that mimic the streptococcal; SspB Adherence Region (BAR) and function as inhibitors of P. gingivalis adherence to streptococci. The invention also provides methods of making and using the inhibitors.

    摘要翻译： 本发明提供了式（I）的非肽化合物，其中：X是 - （C1-C8）环烷基，芳基或 - 芳基（C1-C8）烷基 - ; Y是 - （C1-C8）烷基 - 或不存在; W是杂芳基，（C 3 -C 7）碳环或芳基，其中任何杂芳基，（C 3 -C 7）碳环或W的芳基任选被一个或多个（例如1,2,3,4或5个）Z1基团取代; R 1是（C 1 -C 8）烷基，（C 2 -C 8）烯基，（C 2 -C 8）炔基或芳基，其中芳基任选地被一个或多个（例如，1,2,3,4或5） C1-C8）烷基，（C2-C8）烯基，（C2-C8）炔基，（C3-C7）碳环，卤代（C1-C3）烷基，-CN，NO2，卤素，-ORa，-SRa，-S （O）2 NR b R c，-NR b R c，-NR a COR d，-C（O）R a，-C（O）OR a和-C（O）NR b R c; R 2是（C 1 -C 8）烷基，（C 2 -C 8）烯基，（C 2 -C 8）炔基或芳基，其中芳基任选地被一个或多个（例如，1,2,3,4或5） C1-C8）烷基，（C2-C8）烯基，（C2-C8）炔基，（C3-C7）碳环，卤代（C1-C3）烷基，-CN，NO2，卤素，-ORe，-SRe，-S （O）2 NR f R g，-NR f R g -NrCORh，-C（O）Re，-C（O）OR e和-C（O）NR f R g; 模仿链球菌的我; SspB粘附区（BAR）并且作为牙龈卟啉单胞菌粘附于链球菌的抑制剂。 本发明还提供了制备和使用抑制剂的方法。

    FIBER-OPTIC BIOSENSOR AND BIOSENSING METHODS
    93.
    发明申请
    FIBER-OPTIC BIOSENSOR AND BIOSENSING METHODS 审中-公开
    光纤生物传感器和生物传感方法

    公开(公告)号：US20140030150A1

    公开(公告)日：2014-01-30

    申请号：US13920881

    申请日：2013-06-18

    申请人： Kyung A. Kang ,  Chong H. Ahn

    发明人： Kyung A. Kang ,  Chong H. Ahn

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6486 ,  G01N33/54373

    摘要： A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic channel, where a surface of the optical waveguide being prepared to bind a target biomarker, and an excitation source to couple an excitation wavelength of light into the optical waveguide. The device also includes a sensor for detecting emission light from the optical waveguide at an emission wavelength characteristic of binding of the target biomarker. Particular devices include multiple waveguides in multiple microfluidic channels. Particular devices include microfluidic channels with serpentine bump structures that aid molecular transport.

    摘要翻译： 一种生物传感器装置，其包括限定至少一个微流体通道的模块，沿其长度的至少一部分暴露于所述微流体通道内的流体流动的光波导，其中所述光波导的表面准备结合靶标生物标志物，以及 用于将光的激发波长耦合到光波导中的激发源。 该装置还包括用于以目标生物标志物结合的发射波长特性检测来自光波导的发射光的传感器。 特定装置包括多个微流体通道中的多个波导。 特定装置包括具有蛇纹石凸起结构的微流体通道，其有助于分子运输。

    PNEUMATIC PUMP OPERABLE WITHOUT ELECTRICITY, PUMPING APPARATUS, AND APPLICATIONS THEREOF
    94.
    发明申请
    PNEUMATIC PUMP OPERABLE WITHOUT ELECTRICITY, PUMPING APPARATUS, AND APPLICATIONS THEREOF 审中-公开
    气动泵，无电气，泵装置及其应用

    公开(公告)号：US20130338591A1

    公开(公告)日：2013-12-19

    申请号：US13921734

    申请日：2013-06-19

    申请人： University of Louisville Research Foundation, Inc.

    发明人： Shamus McNamara ,  William D. Ehringer ,  Stephanie Miles ,  Alex Bell ,  Kunal Pharas

    IPC分类号： A61M5/142

    CPC分类号： A61M5/14212 ,  A61M5/14224 ,  A61M5/14244 ,  A61M2005/14513

    摘要： Infusion pumps that do not require electricity for operation are disclosed for various applications, including but not limited to pharmaceutical delivery of medications. A substance, which can be liquid, is stored in a reservoir and driven pneumatically by pressure generated by thermal transpiration, which requires a temperature difference existing between two ends of a narrow channel. In the case of pharmaceutical delivery, the medication is delivered to the treatment site via an applicator. Power sources other than electricity include, but are not limited to, the temperature of a person's body heat exceeding the ambient temperature of surrounding air.

    摘要翻译： 不需要电力的输液泵被公开用于各种应用，包括但不限于药物的药物递送。 可以是液体的物质被储存在储存器中并通过热蒸腾产生的压力而被气动地驱动，这需要存在于狭窄通道的两端之间的温差。 在药物递送的情况下，药物通过施用器输送到治疗部位。 电力以外的电源包括但不限于人体体温超过周围环境温度的温度。