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    DNA encoding an 18 KD CDK6 inhibiting protein and antibodies thereto
    91.
    发明授权
    DNA encoding an 18 KD CDK6 inhibiting protein and antibodies thereto 失效
    编码18KD CDK6抑制蛋白质的DNA及其抗体

    公开(公告)号：US5629407A

    公开(公告)日：1997-05-13

    申请号：US486410

    申请日：1995-06-07

    申请人： Yue Xiong ,  Kunliang Guan

    发明人： Yue Xiong ,  Kunliang Guan

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N9/12 ,  C12N15/12 ,  C07K16/00

    CPC分类号： C12N9/12 ,  C07K14/4738 ,  A61K38/00

    摘要： A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are refered to as p18.sup.INK6 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.

    摘要翻译： 编码CDK抑制蛋白质，特别是CDK6抑制蛋白质的核酸选自：（a）具有本文给出的核苷酸序列的SEQ ID NO：1的DNA（其编码具有给出的氨基酸序列的蛋白质） 本文作为SEQ ID NO：2），并且其被称为p18INK6; （b）与上述（a）的DNA杂交并编码CDK抑制蛋白质的核酸; 和（c）由于遗传密码的简并性而编码由上述（a）或（b）的DNA编码的CDK抑制蛋白的上述（a）或（b）的DNA不同的核酸。 还公开了含有此类DNA的构建体，含有此类构建体的细胞，由此DNA编码的蛋白质，与其结合的抗体，对应于该DNA的反义寡核苷酸及其使用方法。

    E2F-2, a novel mammalian transcription factor
    92.
    发明授权
    E2F-2, a novel mammalian transcription factor 失效
    E2F-2，一种新型哺乳动物转录因子

    公开(公告)号：US5473056A

    公开(公告)日：1995-12-05

    申请号：US136119

    申请日：1993-10-13

    申请人： Mona Ivey-Hoyle ,  Allen I. Oliff ,  David C. Heimbrook

    发明人： Mona Ivey-Hoyle ,  Allen I. Oliff ,  David C. Heimbrook

    IPC分类号： A61K38/00 ,  C07K14/47

    CPC分类号： C07K14/4738 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention is directed to a novel protein with E2F-like properties and the cDNA that encodes for that protein. The purified protein exhibits biological activity which is deemed important to medical science in the study of cell cycle regulation in general and the specific study of the Rb rumor suppressor protein and certain viral oncogenes. The protein may be employed in a complex with pRb or other cellular proteins to study inhibitors of biochemical transformations of those proteins, such as for example the phosphorylation of the pRb portion of the complex, therefore aiding in the study of potential pharmaceutical agents useful against certain oncoproteins encoded by DNA tumor viruses.

    摘要翻译： 本发明涉及具有E2F样特性的新蛋白质和编码该蛋白质的cDNA。 纯化的蛋白质表现出生物活性，这在生物活性中被认为对于医学科学在一般的细胞周期调控的研究和Rb肿瘤抑制蛋白和某些病毒致癌基因的具体研究中是重要的。 蛋白质可以用于与pRb或其它细胞蛋白质的复合物中，以研究这些蛋白质的生物化学转化的抑制剂，例如复合物的pRb部分的磷酸化，因此有助于研究对某些有用的潜在药剂 由DNA肿瘤病毒编码的癌蛋白。