公开(公告)号：US10584118B2

公开(公告)日：2020-03-10

申请号：US15739083

申请日：2016-06-21

申请人： ACTELION PHARMACEUTICALS LTD

发明人： Hamed Aissaoui ,  Martin Bolli ,  Christoph Boss ,  Sylvia Richard-Bildstein ,  Patrick Sieber

IPC分类号： C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D263/54 ,  C07D263/58 ,  C07D277/62 ,  C07D417/14 ,  C07D471/10 ,  C07D491/107 ,  A61P11/00 ,  A61P35/04

摘要： The invention relates to 2,5-disubstituted benzoxazole and benzothiazole derivatives of Formula (I) wherein L, X, Y, and ring (A) are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds may be useful for the prevention or treatment of diseases or disorders associated with impaired reactive oxygen species (ROS) production, and/or for the prevention or treatment of various fibrotic diseases.

公开(公告)号：US09525143B2

公开(公告)日：2016-12-20

申请号：US14732097

申请日：2015-06-05

申请人： Semiconductor Energy Laboratory Co., Ltd.

发明人： Harue Osaka ,  Takahiro Ushikubo ,  Tsunenori Suzuki ,  Nobuharu Ohsawa

IPC分类号： C07D263/54 ,  C07D235/04 ,  C07D235/18 ,  C07D263/57 ,  H01L51/00 ,  C07D413/12 ,  H01L51/50

CPC分类号： H01L51/0061 ,  C07D235/18 ,  C07D263/57 ,  C07D413/12 ,  H01L51/0052 ,  H01L51/006 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0074 ,  H01L51/0081 ,  H01L51/0085 ,  H01L51/5012 ,  H01L51/5056 ,  Y02E10/549 ,  Y02P70/521

摘要： A novel triarylamine compound having a bipolar property is provided. The triarylamine compound can be used for a hole-injection layer, a hole-transport layer, a light-emitting layer, or an electron-transport layer in a light-emitting element. The triarylamine compound can also be used as a host material with a light-emitting material which emits relatively short-wavelength light, in a structure where the host material and the guest material constitute a light-emitting layer. The triarylamine compound of the present invention is a fluorescent compound and therefore can also be used as a light-emitting substance of a light-emitting layer. A light-emitting element having high emission efficiency is provided. A light-emitting device, an electronic device, or a lighting device having low power consumption is provided.

公开(公告)号：US08211923B2

公开(公告)日：2012-07-03

申请号：US12669979

申请日：2008-07-25

申请人： Holger Wagner ,  Elke Langkopf ,  Matthias Eckhardt ,  Ruediger Streicher ,  Corinna Schoelch ,  Annette Schuler-Metz ,  Alexander Pautsch

发明人： Holger Wagner ,  Elke Langkopf ,  Matthias Eckhardt ,  Ruediger Streicher ,  Corinna Schoelch ,  Annette Schuler-Metz ,  Alexander Pautsch

IPC分类号： A61K31/404 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  C07D277/62 ,  C07D263/54 ,  C07D235/04 ,  C07D231/56 ,  C07D209/04

CPC分类号： C07F9/5728 ,  C07F9/65038 ,  C07F9/65068 ,  C07F9/65324 ,  C07F9/6541 ,  C07F9/655354 ,  C07F9/65583 ,  C07F9/65586

摘要： The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.

摘要翻译： 本发明涉及以下通式的取代芳基磺酰氨基甲基膦酸衍生物其中R，X，Y和Z如权利要求1所定义，其互变异构体，对映异构体，非对映体，其混合物及其盐具有有价值的药理学性质， 的糖原磷酸化酶a与糖原相关蛋白磷酸酶1（PP1）的GL亚基的相互作用，以及它们作为药物组合物的用途。

公开(公告)号：US08093241B2

公开(公告)日：2012-01-10

申请号：US12640140

申请日：2009-12-17

申请人： Yuji Nakamura ,  Masayuki Morita ,  Tetsuo Yoneda ,  Kenji Izakura

发明人： Yuji Nakamura ,  Masayuki Morita ,  Tetsuo Yoneda ,  Kenji Izakura

IPC分类号： A01N43/84 ,  A01N37/18 ,  A01N43/60 ,  A01N43/40 ,  A01N43/56 ,  A01N43/42 ,  C07C233/64 ,  C07D409/02 ,  C07D231/10 ,  C07D213/46 ,  C07D215/14 ,  C07D263/54

CPC分类号： A01N37/20 ,  C07C233/76 ,  C07C307/02 ,  C07C309/65 ,  C07C309/66 ,  C07C311/08 ,  C07C317/32 ,  C07C323/42 ,  C07C329/06 ,  C07D209/14 ,  C07D213/50 ,  C07D213/61 ,  C07D317/46 ,  C07D317/58 ,  C07D319/20 ,  C07D333/22 ,  C07D333/28

摘要： The present invention relates to an acid amid derivative of the formula (I) or a salt thereof: wherein A is phenyl which may be substituted by X, benzyl which may be substituted by X, naphthyl which may be substituted by X, a heterocyclic group which may be substituted by X, a fused heterocyclic group which may be substituted by X, indanyl (the indanyl may be substituted by halogen, alkyl or alkoxy) or tetrahydronaphthyl (the tetrahydronaphthyl may be substituted by halogen, alkyl or alkoxy), B is alkyl, cycloalkyl, phenyl which may be substituted by Y, a heterocyclic group which may be substituted by Y, or a condensed heterocyclic group which may be substituted by Y, each of R1 and R2 is alkyl, cyano or —CO2R14, or R1 and R2 may together form a 3- to 6-membered saturated carbocyclic ring, R3 is hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl, —COR15, —S(O)mR16 or —S(O)nNR17R18, which is useful as an active ingredient of pesticides.

摘要翻译： 本发明涉及式（I）的酸酰胺衍生物或其盐：其中A为可被X取代的苯基，可被X取代的苄基，可被X取代的萘基，杂环基 其可以被X取代，可以被X取代的稠合杂环基，茚满基（茚满基可以被卤素，烷基或烷氧基取代）或四氢萘基（四氢萘基可以被卤素，烷基或烷氧基取代），B是 烷基，环烷基，可被Y取代的苯基，可被Y取代的杂环基或可被Y取代的稠合杂环基，R 1和R 2各自为烷基，氰基或-CO 2 R 14，或R 1和 R2可以一起形成3至6元饱和碳环，R 3是氢，烷基，烷氧基烷基，烷硫基烷基，-COR 15，-S（O）m R 16或-S（O）n NR 17 R 18，其可用作 农药。

公开(公告)号：US08030495B2

公开(公告)日：2011-10-04

申请号：US12600960

申请日：2008-05-19

申请人： Paul J. Coleman ,  Swati P. Mercer ,  Anthony J. Roecker

发明人： Paul J. Coleman ,  Swati P. Mercer ,  Anthony J. Roecker

IPC分类号： C07D277/62 ,  C07D261/20 ,  C07D263/54 ,  C07D249/04 ,  C07D401/14 ,  C07D473/02 ,  C07D241/36 ,  C07D471/02 ,  C07D413/14 ,  A61K31/50 ,  A61K31/501 ,  A61K31/4965 ,  A61K31/52 ,  A61K31/505 ,  A61K31/44 ,  A61K31/42 ,  A61K31/415

CPC分类号： C07D417/14 ,  A61K31/401 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/41 ,  C07D403/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D473/36 ,  C07D498/04

摘要： The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的环丙基脯氨酸双酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

公开(公告)号：US20110207748A1

公开(公告)日：2011-08-25

申请号：US13024643

申请日：2011-02-10

申请人： Bob M. Moore, II ,  Himanshu Bhattacharjee ,  Suni Mustafa

发明人： Bob M. Moore, II ,  Himanshu Bhattacharjee ,  Suni Mustafa

IPC分类号： A61K31/505 ,  C07D211/78 ,  A61K31/44 ,  C07D239/24 ,  C07D235/04 ,  A61K31/4184 ,  C07D277/62 ,  A61K31/428 ,  C07D263/54 ,  A61K31/423 ,  A61P25/00

CPC分类号： C07D307/42 ,  C07D307/46

摘要： Cannabinoid derivatives according to formula (I) are disclosed wherein, X, Y, R1, R2, and W can have the definitions provided herein. Without limitation, use of such compounds, their salts or pro-drug, or compositions containing the compounds, salts, or pro-drug, to modify the activity of CB1 and CB2 receptors and treat conditions mediated by these receptors.

摘要翻译： 公开了根据式（I）的大麻素衍生物，其中X，Y，R 1，R 2和W可具有本文提供的定义。 不限于此，使用这些化合物，其盐或前药，或含有化合物，盐或前药的组合物来改变CB1和CB2受体的活性并治疗由这些受体介导的病症。

公开(公告)号：US07799927B2

公开(公告)日：2010-09-21

申请号：US11410967

申请日：2006-04-26

申请人： Shin-Shin Wang ,  Chien-Wen Chen ,  Jong-Lieh Yang ,  Chii-Chang Lai ,  Hui-Ping Tsai ,  Wen-Ping Chu ,  Wen-Yih Liao ,  Chien-Liang Huang ,  Tzuan-Ren Jeng ,  Ching-Yu Hsieh ,  An-Tse Lee

发明人： Shin-Shin Wang ,  Chien-Wen Chen ,  Jong-Lieh Yang ,  Chii-Chang Lai ,  Hui-Ping Tsai ,  Wen-Ping Chu ,  Wen-Yih Liao ,  Chien-Liang Huang ,  Tzuan-Ren Jeng ,  Ching-Yu Hsieh ,  An-Tse Lee

IPC分类号： C07D517/02 ,  C07D277/62 ,  C07D263/54 ,  C07D235/04 ,  C07D209/04

CPC分类号： C07D209/14 ,  C07D277/64 ,  G11B7/2467 ,  G11B7/2472 ,  G11B7/2478 ,  G11B7/2495 ,  G11B2007/24612

摘要： An indolestyryl compound. The indolestyryl compound has formula (I): wherein Z1 comprises benzene, naphthalene, or heterocyclic ring containing O, S, or N, R2 comprises H, halogen atoms, C1-5 alkyl, nitro, ester, carboxyl, sulfo, sulfonamide, sulfuric ester, amide, C1-3 alkoxy, amino, alkylamino, cyano, C1-6 alkylsulfonyl, or C2-7 alkoxy carbonyl, R3, R4, R5, and R6 comprise H, alkyl, aralkyl, or heterocyclic ring containing O, S, or N, R7 and R8 comprise H or alkyl, R10 comprises H, alkyl, halogen atoms, nitro, hydroxyl, amino, ester, or substituted or non-substituted sulfonyl, W comprises carbon or nitrogen, Y comprises carbon, oxygen, sulfur, selenium, —NR, or —C(CH3)2, m is 1˜3, and X1 comprises an anionic group or an anionic organometallic complex, wherein R3 and R4 are joined to a nitrogen atom or R5 and R6 are joined together to form a ring, and R bonded to nitrogen is C1-5 alkyl.

摘要翻译： 吲哚满甲基化合物。 该吲哚美辛化合物具有式（I）：其中Z 1包含苯，萘或含有O，S或N的杂环，R 2包含H，卤素原子，C 1-5烷基，硝基，酯，羧基，磺基，磺酰胺，硫酸 酯，酰胺，C 1-3烷氧基，氨基，烷基氨基，氰基，C 1-6烷基磺酰基或C 2-7烷氧基羰基，R 3，R 4，R 5和R 6包含H，烷基，芳烷基或含有O， 或N，R 7和R 8包含H或烷基，R 10包含H，烷基，卤素原子，硝基，羟基，氨基，酯或取代或未取代的磺酰基，W包括碳或氮，Y包括碳，氧， 硒，-NR或-C（CH 3）2，m为1〜3，X 1为阴离子性基团或阴离子性有机金属络合物，其中，R 3和R 4与氮原子连接，R 5和R 6连接在一起形成 与R键合的环是C1-5烷基。

公开(公告)号：US20090197863A1

公开(公告)日：2009-08-06

申请号：US12355692

申请日：2009-01-16

申请人： Daniel Chu ,  Bing Wang

发明人： Daniel Chu ,  Bing Wang

IPC分类号： A61K31/422 ,  C07D263/54 ,  A61K31/423 ,  A61K31/496 ,  C07D413/02 ,  A61P35/00

CPC分类号： C07D263/57 ,  C07D413/04 ,  C07D413/10 ,  C07D455/02 ,  C07D487/04 ,  C07D487/08

摘要： A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

摘要翻译： 具有式（I）或式（II）所示结构的化合物：其中变量Y，R1，R2，R3和R4如本文所定义。 本文提供了聚（ADP-核糖）聚合酶活性的抑制剂。 本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗通过抑制PARP活性而改善的疾病，病症和病症的药物组合物。

公开(公告)号：US20090105447A1

公开(公告)日：2009-04-23

申请号：US11886138

申请日：2006-03-08

申请人： Thomas Schafer ,  Beat Schmidhalter ,  Peter Murer ,  Kristina Bardon ,  Tobias Hintermann

发明人： Thomas Schafer ,  Beat Schmidhalter ,  Peter Murer ,  Kristina Bardon ,  Tobias Hintermann

IPC分类号： C08G73/06 ,  C08G65/00 ,  C07D235/04 ,  C07D263/54 ,  C07D241/38 ,  C07D239/70 ,  C07D241/40

CPC分类号： H01L51/0035 ,  C08G61/12 ,  C08G61/122 ,  C08G61/124 ,  C08G61/125 ,  C08G61/126 ,  H01L51/5012 ,  Y02E10/549

摘要： The present invention relates to polymers comprising a repeating unit of the formula (I), and their use in electronic devices. The polymers according to the invention have excellent 5 solubility in organic solvents and excellent film-forming properties. In addition, high charge carrier mobilities and high temperature stability of the emission color are observed, if the polymers according to the invention are used in polymer light emitting diodes (PLEDs).

摘要翻译： 本发明涉及包含式（I）的重复单元的聚合物及其在电子器件中的用途。 根据本发明的聚合物在有机溶剂中的溶解度优异且成膜性优异。 此外，如果根据本发明的聚合物用于聚合物发光二极管（PLED）中，则观察到高电荷载流子迁移率和发光颜色的高温稳定性。

公开(公告)号：US20090087376A1

公开(公告)日：2009-04-02

申请号：US11632328

申请日：2005-07-15

申请人： Brian Bacskai ,  Bradley T. Hyman ,  William E. Klunk ,  Chester A. Mathis ,  Timothy Swager ,  Evgueni Nesterov ,  Ivory Hills

发明人： Brian Bacskai ,  Bradley T. Hyman ,  William E. Klunk ,  Chester A. Mathis ,  Timothy Swager ,  Evgueni Nesterov ,  Ivory Hills

IPC分类号： A61K51/04 ,  C07D249/04 ,  C07D403/02 ,  C07D277/62 ,  C07D263/54 ,  C07D209/04 ,  A61P25/00 ,  C07D409/02 ,  C07D333/50 ,  A61K49/00 ,  A61K49/06

CPC分类号： C07D333/54 ,  C07D333/18 ,  C07D409/04 ,  C07D409/14 ,  C07D417/14

摘要： The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. The invention relates, in part, to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease. The present invention also relates to therapeutic uses for such compounds, as exemplified by compounds of the formula (1) in which Y is independently S, O, or N and m is 1, 2, or 3.

摘要翻译： 本发明涉及适合于在活体患者中淀粉样沉积成像的化合物的鉴定。 本发明部分地涉及在体内成像淀粉样蛋白沉积物的方法，以允许阿尔茨海默氏病的止血诊断。 本发明还涉及这样的化合物的治疗用途，例如式（1）化合物，其中Y独立地为S，O或N，m为1,2或3。