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    Molecular actuators, and methods of use thereof
    1.
    发明申请
    Molecular actuators, and methods of use thereof 有权
    分子致动器及其使用方法

    公开(公告)号：US20070215839A1

    公开(公告)日：2007-09-20

    申请号：US11603314

    申请日：2006-11-21

    Applicant: Patrick Anquetil ,  Ian Hunter ,  John Madden ,  Peter Madden ,  Anthony Pullen ,  Timothy Swager ,  Bing Xu ,  Hsiao-hua Yu

    Inventor： Patrick Anquetil ,  Ian Hunter ,  John Madden ,  Peter Madden ,  Anthony Pullen ,  Timothy Swager ,  Bing Xu ,  Hsiao-hua Yu

    IPC: H01B1/00 ,  C07D495/00

    CPC classification number: H01B1/127 ,  C08G61/122 ,  H01B1/128

    Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π-π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

    Abstract translation: 报道了噻吩基导电聚合物分子致动器的合成，显示出电触发的分子构象转变。 认为激发是聚合物骨架在分子水平上的构象重排的结果，而不是简单地在电化学活化时主体聚合物链中的离子嵌入。 分子致动由氧化后噻吩低聚物的pi-pi堆叠产生，产生可逆的分子位移，导致令人惊奇的材料性质，例如电可控孔隙率和大应变。 活性分子构象变化的存在由原位电化学数据支持。 已经使用单分子技术来表征分子致动器。

    Emissive polymers and devices incorporating these polymers
    2.
    发明申请
    Emissive polymers and devices incorporating these polymers 有权
    发射聚合物和掺入这些聚合物的装置

    公开(公告)号：US20070081921A1

    公开(公告)日：2007-04-12

    申请号：US11541028

    申请日：2006-09-29

    Applicant: Timothy Swager ,  John Amara

    Inventor： Timothy Swager ,  John Amara

    IPC: G01N21/00

    CPC classification number: C09K11/06 ,  C08G61/02 ,  C09K9/02 ,  C09K2211/1425 ,  Y10T436/14 ,  Y10T436/145555

    Abstract: The present invention relates to a class of luminescent and conductive polymer compositions having chromophores, and particularly solid films of these compositions exhibiting increased luminescent lifetimes, quantum yields and amplified emissions. These desirable properties can be provided through polymers having rigid groups designed to prevent polymer reorganization, aggregation or π-stacking upon solidification. These polymers can also display an unusually high stability with respect to solvent and heat exposures. The invention also relates to a sensor and a method for sensing an analyte through the luminescent and conductive properties of these polymers. Analytes can be sensed by activation of a chromophore at a polymer surface. Analytes include aromatics such as heterocycles, phosphate ester groups and in particular explosives and chemical warfare agents in a gaseous state. The present invention also relates to devices and methods for amplifying emissions by incorporating a polymer having an energy migration pathway and/or providing the polymer as a block co-polymer or as a multi-layer.

    Abstract translation: 本发明涉及一类具有发色团的发光和导电聚合物组合物，特别是这些组合物的固体膜显示增加的发光寿命，量子产率和放大的发射。 这些期望的性质可以通过具有刚性基团的聚合物来提供，所述刚性基团被设计成在凝固时防止聚合物重组，聚集或π层叠。 这些聚合物在溶剂和热暴露方面也能表现出非常高的稳定性。 本发明还涉及通过这些聚合物的发光和导电性质来感测分析物的传感器和方法。 可以通过在聚合物表面活化发色团来感测分析物。 分析物包括芳族化合物如杂环，磷酸酯基团，特别是气体中的爆炸物和化学战剂。 本发明还涉及通过引入具有能量迁移途径的聚合物和/或提供聚合物作为嵌段共聚物或作为多层来扩增发射的装置和方法。

    Organic materials able to detect analytes
    4.
    发明申请
    Organic materials able to detect analytes 有权
    有机材料能够检测分析物

    公开(公告)号：US20060073607A1

    公开(公告)日：2006-04-06

    申请号：US11005631

    申请日：2004-12-06

    Applicant: Aimee Rose ,  Timothy Swager ,  Zhengguo Zhu ,  Vladimir Bulovic ,  Conor Madigan

    Inventor： Aimee Rose ,  Timothy Swager ,  Zhengguo Zhu ,  Vladimir Bulovic ,  Conor Madigan

    IPC: G01N30/00

    CPC classification number: G01N21/7703 ,  G01N33/0057 ,  H01S3/067 ,  H01S3/178 ,  H01S5/12 ,  H01S5/36 ,  H01S2301/02

    Abstract: The present invention generally relates to polymers with lasing characteristics that allow the polymers to be useful in detecting analytes. In one aspect, the polymer, upon an interaction with an analyte, may exhibit a change in a lasing characteristic that can be determined in some fashion. For example, interaction of an analyte with the polymer may affect the ability of the polymer to reach an excited state that allows stimulated emission of photons to occur, which may be determined, thereby determining the analyte. In another aspect, the polymer, upon interaction with an analyte, may exhibit a change in stimulated emission that is at least 10 times greater with respect to a change in the spontaneous emission of the polymer upon interaction with the analyte. The polymer may be a conjugated polymer in some cases. In one set of embodiments, the polymer includes one or more hydrocarbon side chains, which may be parallel to the polymer backbone in some instances. In another set of embodiments, the polymer may include one or more pendant aromatic rings. In yet another set of embodiments, the polymer may be substantially encapsulated in a hydrocarbon. In still another set of embodiments, the polymer may be substantially resistant to photobleaching. In certain aspects, the polymer may be useful in the detection of explosive agents, such as 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT).

    Abstract translation: 本发明一般涉及具有允许聚合物用于检测分析物的激光特性的聚合物。 在一个方面，聚合物在与分析物相互作用时可以表现出可以以某种方式确定的激光特性的变化。 例如，分析物与聚合物的相互作用可能影响聚合物达到允许发生光子的受激发射的激发态的能力，这可以被确定，从而确定分析物。 在另一方面，聚合物在与分析物相互作用时可能表现出相对于与分析物相互作用时聚合物自发发射变化的至少10倍的受激发射的变化。 在某些情况下，聚合物可以是共轭聚合物。 在一组实施方案中，聚合物包括一个或多个烃侧链，其在一些情况下可以平行于聚合物主链。 在另一组实施方案中，聚合物可以包括一个或多个芳族环。 在又一组实施方案中，聚合物可以基本上包封在烃中。 在又一组实施方案中，聚合物可以基本上抵抗光漂白。 在某些方面，聚合物可用于检测爆炸剂，例如2,4,6-三硝基甲苯（TNT）和2,4-二硝基甲苯（DNT）。

    Polymers for analyte detection
    6.
    发明申请
    Polymers for analyte detection 有权

    公开(公告)号：US20060127929A1

    公开(公告)日：2006-06-15

    申请号：US11230308

    申请日：2005-09-19

    Applicant: Timothy Swager ,  Peter Seeberger ,  Juan Zheng ,  Matthew Disney

    Inventor： Timothy Swager ,  Peter Seeberger ,  Juan Zheng ,  Matthew Disney

    IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/00

    CPC classification number: G01N33/542 ,  C12Q1/6818 ,  G01N2400/10

    Abstract: The present invention generally relates to organic polymers able to participate in an analyte-recognition process, where an analyte facilitates an energy transfer between an energy donor and an energy acceptor. Certain embodiments of the invention make use of fluorescent conjugated polymers, such as poly(phenylene ethynylene)s and other polymers comprising pi-conjugated backbones. For example, one aspect of the invention provides a fluorescent conjugated polymer and an indicator that can interact with each other in the presence of an analyte to produce an emissive signal. In some cases, the interaction may include energy exchange mechanisms, such as Dexter energy transfer or the strong coupling effect. The interaction of the conjugated polymer and the indicator, in some instances, may be facilitated through specific interactions, such as a protein/carbohydrate interaction, a ligand/receptor interaction, etc. Another aspect of the invention provides for the detection of biological entities, for example, pathogenic bacteria such as E. coli, or viruses such as influenza virus. In some cases, biological recognition elements may be used to determine the biological entity, for instance, carbohydrates that can be used to specifically interact with at least part of the biological entity, such as a protein in the cell membrane of a bacterium. Still other aspects of the invention involve articles, devices, and kits using any of the above-described systems.

    High internal free volume compositions for low-k dielectric and other applications
    9.
    发明申请
    High internal free volume compositions for low-k dielectric and other applications 失效
    用于低k电介质和其他应用的高内部自由体积组成

    公开(公告)号：US20070117954A1

    公开(公告)日：2007-05-24

    申请号：US11336417

    申请日：2006-01-20

    Applicant: Timothy Swager ,  Jean Bouffard

    Inventor： Timothy Swager ,  Jean Bouffard

    IPC: C08G61/02

    CPC classification number: C08G61/122

    Abstract: The present invention provides materials, devices, and methods involving new heterocyclic, shape-persistent monomeric units with internal free volume. In some cases, materials the present invention may comprise monomers, oligomers, or polymers that incorporate a heterocyclic, shape-persistent iptycene. The present invention may provide materials having low dielectric constants and improved stability at high operating temperatures due to the electron-poor character of materials. In addition, compositions of the invention may be easily synthesized and readily modified to suit a particular application.

    Abstract translation: 本发明提供涉及具有内部自由体积的新型杂环，形状 - 持续性单体单元的材料，装置和方法。 在一些情况下，本发明的材料可以包含掺入杂环，形状持久的iycycene的单体，低聚物或聚合物。 本发明可以提供具有低介电常数的材料，并且由于材料的电子贫乏特性而在高操作温度下提高了稳定性。 此外，本发明的组合物可以容易地合成并容易地修饰以适合特定的应用。

    Methods for the synthesis of milnacipran and congeners thereof
    10.
    发明申请
    Methods for the synthesis of milnacipran and congeners thereof 有权
    合成米那普仑及其同系物的方法

    公开(公告)号：US20050282898A1

    公开(公告)日：2005-12-22

    申请号：US11097466

    申请日：2005-04-01

    Applicant: Stephen Buchwald ,  Timothy Swager ,  Roman Rariy

    Inventor： Stephen Buchwald ,  Timothy Swager ,  Roman Rariy

    IPC: A61K31/195 ,  C07C61/16 ,  C07D209/48 ,  C07D307/00

    CPC classification number: C07D209/48 ,  C07D307/00

    Abstract: One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

    Abstract translation: 本发明的一个方面涉及合成米那普仑或其同系物的方法。 本发明的另一方面涉及用于合成对映体富集的米那普仑或其同系物的不对称方法。 本发明还涉及用于合成对映体富集的米那普仑或其同系物的非对称或非对称方法中的中间体的方法。

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