摘要:
This invention relates to crosslinked collagen and glycosaminoglycan materials, and to procedures for preparing such materials. It has been discovered that if collagen fibrils in an aqueous acidic solution are contacted with a crosslinking agent before being contacted with glycosaminoglycan, the materials produced have extremely low levels of thrombogenicity. Such materials are well suited for in-dwelling catheters, blood vessel grafts, and other devices that are in continuous contact with blood for long periods of time.
摘要:
Chemically-modified quaternary-structured fiber collagens of minimum molecular length, diameter and periodicity, and containing a relatively high positive electrostatic charge are claimed as hemostatic agents. Specific examples are guanidinated, esterified, and guanidinated-esterified collagen fibers of the type described.
摘要:
An improved collagen gel soft contact lens is prepared from an aldehyde-crosslinked, lens-shaped collagen gel containing a water-soluble, aliphatic, monomeric, polyhydroxy compound, e.g., glucose.
摘要:
AQUEOUS SWOLLEN COLLAGEN OF DOUGH--LIKE CONSISTENCY IS RAISED IN PH WHEREUPON IT DE-SWELLS OR SHRINKS. FIBER REINFORCEMENT CAN THEN BE STIRRED INTO THE AQUEOUS PHASE. UPON RE-ACIDFICATION, THE COLLAGEN AGAIN SWELLS WITH THE FIBER RE-INFORCEMENT DISTRIBUTED SUBSTANTIALLY UNIFORMLY THERETHROUGH. IF DESIRED, A DISPERSION OF AN ESTER OF POLYACRYLIC ACID OR POLYVINYLIDENE CHLORIDE CAN BE INCORPORATED IN THE MASS, PREFERABLY BEFORE RE-SWELLING. THE PRODUCT CAN THEN BE SHAPED IN KNOWN MANNER, AS BY EXTRUSION, AND DE-WATERED AS BY COAGULATION AND/OR DRYING.