公开(公告)号：US11821971B2

公开(公告)日：2023-11-21

申请号：US17765315

申请日：2021-09-07

申请人： MUSC Foundation for Research Development

发明人： Dale H. Mugler ,  William S. Clary

IPC分类号： G01R33/46 ,  G01R33/485

CPC分类号： G01R33/4625 ,  G01R33/485

摘要： A method comprising collecting magnetic resonance imaging (MRI) scanner data corresponding to a region of interest, establishing a spectral peak profile associated with at least one metabolite in the region of interest, wherein the spectral peak profile comprises a term in the FID vector signal included in the collected MRI scanner data, selecting at least three counter indices and corresponding points on the spectral peak profile to compute a linear fractional transformation (LFT), computing an N-dimensional vector outlining a spectral circle in a complex plane by applying the LFT to each counter index included in a set of equally-spaced counter indices associated with a three-dimensional spectrum representation of the collected MRI scanner data, shifting the spectral circle to eliminate a baseline offset for a magnitude spectrum associated with the complex plane, rotating the shifted spectral circle to produce a rotated spectral circle.

公开(公告)号：US20230355167A1

公开(公告)日：2023-11-09

申请号：US18160995

申请日：2023-01-27

申请人： ACLARION, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Jeffrey C. Lotz ,  James Clayton Peacock, III ,  David S. Bradford ,  Stefan Dudli ,  Sergey G. Magnitsky

IPC分类号： A61B5/00 ,  A61B5/055 ,  G01R33/465 ,  G01R33/48 ,  G01R33/56 ,  G01R33/483 ,  G01R33/46 ,  G01R33/485

CPC分类号： A61B5/4514 ,  A61B5/055 ,  A61B5/412 ,  A61B5/4566 ,  G01R33/465 ,  G01R33/4828 ,  G01R33/5608 ,  G01R33/483 ,  G01R33/46 ,  G01R33/485

摘要： An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).

公开(公告)号：US11650274B2

公开(公告)日：2023-05-16

申请号：US17712548

申请日：2022-04-04

申请人： Xiamen University

发明人： Yuqing Huang ,  Zhong Chen ,  Cunyuan Gao ,  Haolin Zhan

IPC分类号： G01R33/485 ,  G01R33/46

CPC分类号： G01R33/485 ,  G01R33/4625

摘要： A method for acquiring nuclear magnetic resonance (NMR) phase-sensitive two-dimensional (2D) J-resolved spectrum by suppressing strong coupling spurious peaks, comprising: 1) placing a sample, collecting a conventional one-dimensional (1D) spectrum of the sample, and measuring a time width (pw) of a 90° pulse, wherein the conventional 1D spectrum provides J coupling information and chemical shift information of the sample; and 2) introducing a pulse sequence for suppressing strong coupling, setting parameters of a chirp sweep frequency pulse, a pure shift yielded by chirp excitation (PSYCHE) module, and a J sampling module, and collecting and saving data of a spectrum.

公开(公告)号：US20230140742A1

公开(公告)日：2023-05-04

申请号：US18050841

申请日：2022-10-28

申请人： ACLARION, INC.

发明人： James Charles Abel ,  James Clayton Peacock, III ,  Ricardo Dario Pradenas

IPC分类号： G01R33/485 ,  G01R33/48 ,  G16H50/20

摘要： Systems and methods are provided for using machine learning (ML) models to evaluate data generated during MRI procedures, such as magnetic resonance spectroscopy (MRS) data, to evaluate patient disc pain. An ML-based disc assessment system can evaluate MRS spectrum data ML models trained to classify the MRS spectrum based on diagnostic and/or outcome-based ground truth data.

公开(公告)号：US20220390538A1

公开(公告)日：2022-12-08

申请号：US17641829

申请日：2020-09-11

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Holger EGGERS

IPC分类号： G01R33/48 ,  G01R33/485 ,  G01R33/56 ,  G01R33/561

摘要： The invention relates to a method of Dixon-type MR imaging of an object (10) placed in an examination volume of a MR device (1). It is an object of the invention to provide a method that enables an improved Dixon water/fat separation in combination with a dual-acquisition gradient-echo imaging sequence. The method comprises the steps of: subjecting the object (10) to a dual-acquisition gradient-echo imaging sequence comprising a series of temporally equidistant RF excitations, wherein one gradient echo is generated in each repetition time between successive RF excitations with the echo time alternating between a first and a second value (TE1, TE2), and wherein phase-encoding magnetic field gradients (P, S) are switched in each repetition time to sample a pre-defined region of k-space; acquiring echo signals from the object (10), wherein each gradient echo associated with either the first or the second echo time value (TE1, TE2) is sampled as a partial echo, and—reconstructing an MR image from the acquired echo signals, whereby signal contributions from water and fat are separated. Moreover the invention relates to an MR device (1) and to a computer program to be run on an MR device (1).

公开(公告)号：US11486948B2

公开(公告)日：2022-11-01

申请号：US16631741

申请日：2018-02-23

申请人： AMRA Medical AB

发明人： Olof Dahlqvist Leinhard

IPC分类号： G01V3/00 ,  G01R33/48 ,  G01R33/485 ,  G01R33/50 ,  G01R33/56

摘要： The present invention relates to a method of calculating a proton density fat fraction, PDFF, from a water and fat separated magnetic resonance imaging, MRI, based on fat-referenced lipid quantification in a region of interest (ROI) and using determination of a reference tissue. The method comprises the step of determining: F·βf/R, wherein F is the fat signal in the ROI provided from the MRI, βf is a function providing a ratio between T1 saturation values of the fat signals in the reference tissue and in the ROI; and R is a representation of the sum of fat and water signals on an intensity scale where the saturation of each of the fat and water signals equals the saturation of fat in the reference tissue.

公开(公告)号：US20220326326A1

公开(公告)日：2022-10-13

申请号：US17807855

申请日：2022-06-20

申请人： SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.

发明人： Hui LIU ,  Qi LIU ,  Yichen HU

IPC分类号： G01R33/485 ,  G01R33/561 ,  G01R33/24 ,  G01R33/48

摘要： The present disclosure provides a system for MRI. The system may obtain a plurality of echo signals relating to a subject that are excited by an MRI pulse sequence applied to the subject. The system may perform a quantitative measurement on the subject based on the plurality of echo signals. The MRI pulse sequence may include a CEST module configured to selectively excite exchangeable protons or exchangeable molecules in the subject, an RF excitation pulse applied after the CEST module configured to excite a plurality of gradient echoes, and one or more refocusing pulses applied after the RF excitation pulse. Each of the refocusing pulses may be configured to excite one or more spin echoes. The one or more spin echoes excited by at least one of the one or more refocusing pulses may include a symmetric spin echo and one or more asymmetric spin echoes.

公开(公告)号：US20220214415A1

公开(公告)日：2022-07-07

申请号：US17576283

申请日：2022-01-14

申请人： The United States of America, as Represented, by the Secretary, Department of Health & Human Service

发明人： Jeffrey R. Brender ,  James B. Mitchell ,  Kazutoshi Yamamoto ,  Shun Kishimoto ,  Jeeva P. Munasinghe ,  Hellmut Merkle ,  Murali K. Cherukuri

IPC分类号： G01R33/56 ,  G01R33/485 ,  G06T5/00

摘要： Kinetic monitoring of in vivo metabolism of labelled tracers is based on singular value decomposition or Tucker Decomposition of magnetic resonance spectral image data. Data decomposition is used in conjunction with rank reduction to improve signal-to-noise ratio. Rank reduction can be applied in one or more of a spectral, spatial, or temporal dimension. Rank is generally reduced based on a number of expected analytes/metabolites or fit of measured data to a model.

公开(公告)号：US20220175264A1

公开(公告)日：2022-06-09

申请号：US17528047

申请日：2021-11-16

申请人： ACLARION, INC.

发明人： James Clayton Peacock, III ,  John Patrick Claude ,  Paul Henry Kane

IPC分类号： A61B5/055 ,  A61B5/00 ,  G01R33/485

摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

公开(公告)号：US11275140B2

公开(公告)日：2022-03-15

申请号：US16979198

申请日：2019-03-11

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Panu Tapani Vesanen ,  Lizette Warner ,  Jukka Ilmari Tanttu

IPC分类号： G01R33/54 ,  A61B5/00 ,  A61B5/055 ,  A61N5/10 ,  G01R33/24 ,  G01R33/44 ,  G01R33/48 ,  G01R33/483 ,  G01R33/485 ,  G01R33/50 ,  G01R33/56

摘要： A magnetic resonance imaging system is configured to be selectively operated in a default mode and an emulation mode. Execution of machine executable instructions by a processor of the magnetic resonance imaging system causes the magnetic resonance imaging system to receive a selection signal selecting the emulation mode. The magnetic resonance imaging system switches from the default mode to the emulation mode. The magnetic resonance imaging system is operated in the emulation mode using the set of emulation control parameters. The emulated magnetic resonance imaging data is acquired from the imaging zone of the magnetic resonance imaging system.